Nikolay V. Litviakov
M.D., Ph.D., D.Sc., Professor, Head of Department of Viral Oncology, Cancer Research Institute, Tomsk National Research Medical Center.
Contact details
e-mail: nvlitv72@ya.ru
phone: +7 3822 282681
Brief biography
Nikolay V. Litviakov graduated from the master's program of the Biology and Soil Faculty of Tomsk State University in 1998. Since 1996, he has been working at Tomsk Cancer Research Institute: first as a research laboratory assistant, later (2015) as a Head of Laboratory of Viral Oncology. In 2003, he defended his Ph.D. thesis titled «Mechanisms of the immunotropic and antiblastoma action of interferon administered orally via a bacterial vector» in the specialties of physiology and pathological physiology физиология. In 2014, he defended his D.Sc. thesis titled: «Regulation of multidrug resistance gene expression in breast tumors during neoadjuvant chemotherapy » in the specialty of oncology.
Research interests
N.V. Litviakov is a specialist in the field of molecular oncology and cancer genetics. Under his leadership, technologies for personalized neoadjuvant chemotherapy in patients with breast cancer and adjuvant chemotherapy in patients with non-small cell lung cancer have been developed and successfully clinically validated. These technologies made it possible to increase the effectiveness of preoperative chemotherapy from 54 to 88% in patients with breast cancer, as well as to increase the relapse-free survival rate by 25% in patients with lung cancer.
N.V. Litvyakov is engaged in the study of the natural and chemotherapy-induced clonal evolution of the tumor. Under his supervision, it has been established that clonal evolution during the development of a cervical tumor has an individual scenario, not only in terms of the set of driver mutations, but also in terms of the type of clonal relationships. New markers of metastatic clones of breast tumors have been developed and clinical trials of preoperative chemotherapy aimed at eliminating metastatic clones have begun. The team led by Prof. Litvyakov actively cooperates with the clinical departments of the institute and performs molecular genetic analysis for patients.
Under his supervision, 7 Ph.D. dissertations and 2 D.Sc. theses were defended.
N.V. Litviakov is an author of more than 350 publications, of which 169 were published in peer-reviewed journals, and 62 in foreign journals; 4 monographs, 16 patents, and 28 registration certificates for databases. Since 1998, he has been a Lecturer at the Department of Human and Animal Physiology of Tomsk State University.
Achievements, awards and grants
N.V. Litviakov is a member of the Academic Council of the Tomsk National Research Medical Center, member of the Academic Council of the Cancer Research Institute, member of the Coordinating and Scientific-Expert Commissions of the Cancer Research Institute, member of the Dissertation Council in the specialties of oncology, radiation therapy and genetics, member of the editorial board of the Siberian Journal of Oncology, included in the Scopus database. He is an expert of the Russian Science Foundation, member of the Expert Council of the Russian Science Foundation, member of the Joint Scientific Council of the Siberian Branch of the Russian Academy of Sciences in Medical Sciences (2022).
The research of N.V. Litviakov and his colleagues was supported by grants from the Russian Science Foundation, scholarships from the President and the Government of the Russian Federation, the International Science and Technology Center, the Federal Target Program "Personnel" and the Federal Target Program "Research and Development", RFBR, the European grant "ERA.Net Rus Plus" , grants from other Russian foundations.
Nikolay V. Litviakov has been a Principal Investigator for the projects titled:
"Metastatic breast tumor clones" supported by RFBR grant No. 17-15-01203
"Suppression of the ability of tumor cells to stem plasticity to prevent the development of metastatic diseases" supported by the RFBR grant №21-15-00243.
Nikolay V. Litviakov has been Co-Principal Investigator of the project titled:
"Genetic and epigenetic editing of tumor cells and microenvironment in order to block metastasis" Agreement 075-15-2021-1073.
Litvyakov N.V. was awarded honorary titles and prizes: In 2004-2005, he was a grant recipient of the Foundation for the Promotion of Domestic Medicine and the Presidium of the Russian Academy of Medical Sciences. In 2008-2010, 2015, 2017 for success in his professional activities and active public position, he was awarded with certificates of honor and gratitude from the regional administration of the Tomsk region, the Duma of the city of Tomsk, the administration of Tomsk. In 2013 he was awarded the All-Russian Prize in the field of oncology "In Vita Veritas" in the nomination "For achievements in the field of experimental oncology". He is a Laureate of the Tomsk Region Prize in the field of education, science, healthcare and culture (2019). He was awarded the honorary title "Honorary Worker of Science and High Technologies of the Russian Federation" (2020), Honorary Diploma of the Ministry of Science and Higher Education of the Russian Federation (2020), Professor of the Russian Academy of Sciences (2022)
Monographs
- Кжышковска Ю.Г., Стахеева М.Н., Литвяков Н.В., Савельева О.Е., Митрофанова И.В., Степанов И.В., Грачев А.Н., Геращенко Т.С., Завьялова М.В., Чердынцева Н.В.Иммунная система и эффективность противоопухолевого лечения / 2015.- Томск: Изд-во Том. ун-та. – 164 с.DOI 10.17223/978-5-7511-2391-8 (монография) https://www.researchgate.net/publication/292606096_Immunnaa_sistema_i_effektivnost_protivoopuholevogo_lecenia
- Denisov E.V., Cherdyntseva N.V., Litviakov N.V., Malinovskaya E.A., Babyshkina N.N., Belyavskaya V.A., Voevoda M.I. TP53 Gene Polymorphisms in Cancer Risk: The Modulating Effect of Ageing, Ethnicity and TP53 Somatic Abnormalities.//TUMOR SUPPRESSOR GENES 2012.- Edited by Yue Cheng www.intechopen.com P.79-110. DOI: 10.5772/27768 http://www.intechopen.com/books/tumor-suppressor-genes/tp53-gene-polymorphisms-in-cancer-risk-the-modulating-effect-of-ageing-ethnicity-and-tp53-somatic-ab
- Литвяков Н.В., Карпов А.Б., Тахауов Р.М., Фрейдин М.Б., Сазонов А.Э., Халюзова М.В. Генетические маркёры индивидуальной радиочувствительности человека/ Под общ. ред Р.М. Тахауова.- Томск: Изд-во Том. ун-та, 2011.- 186 с. (https://www.researchgate.net/publication/314104444_Geneticeskie_markery_individualnoj_radiocuvstvitelnosti_celoveka)
- Литвяков Н.В., Гончарик О.О., Межерицкий С.А., Васильева Е.О., Карпов А.Б., Тахауов Р.М. Генетические аспекты развития злокачественных новообразований в условиях долговременного радиационного воздействия / Под общ. ред. Р.М. Tахауова. – Томск: Изд-во Том. ун-та, 2010. – 130 с.
Publications
1. Tsyganov MM, Ibragimova MK, Garbukov EY, Tsydenova IA, Gaptulbarova KA, Dolgasheva DS, Zdereva EA, Frolova AA, Slonimskaya EM, Litviakov NV. Predictive and Prognostic Significance of mRNA Expression and DNA Copies Aberrations of ERCC1, RRM1, TOP1, TOP2A, TUBB3, TYMS, and GSTP1 Genes in Patients with Breast Cancer. Diagnostics. 2022; 12(2):405. https://doi.org/10.3390/diagnostics12020405
2. Ibragimova MK, Tsyganov MM, Deryusheva IV, Slonimskaya EM, Litviakov NV. Stem gene expression in breast tumors during chemotherapy: Connection with the main clinical and morphological factors and the disease outcome. Journal of Cancer Research and Therapeutics 2022;18:89-95. DOI: 10.4103/jcrt.JCRT_1331_20 Q3
3. Tsyganov, M.M. Ibragimova, M.K.; Gaptulbarova, K.A.; Tsydenova, I.A.; Dolgasheva, D.S.; Garbukov, E.Y.; Frolova, A.A.; Slonimskaya, E.M.; Litvyakov, N.V. DNA Copy Number Aberrations and Expression of ABC Transporter Genes in Breast Tumour: Correlation with the Effect of Neoadjuvant Chemotherapy and Prognosis of the Disease. Pharmaceutics 2022, 14, 948. https://doi.org/10.3390/pharmaceutics14050948 Q1 IF=6.321
4. Ibragimova, M.; Tsyganov, M.; Litviakov, N. Tumour Stem Cells in Breast Cancer. Int. J. Mol. Sci. 2022, 23, 5058. https://doi.org/10.3390/ijms23095058 Q1 IF=5.924
5. Ibragimova MK, Tsyganov MM, Pevzner AM, Litviakov NV. Transcriptome of Breast Tumors With Different Amplification Status of the Long Arm of Chromosome 8// Anticancer Research. 2021 Jan;41(1):187-195. doi: 0.21873/anticanres.14764 Q2.
6. Litviakov NV, Ibragimova MK, Tsyganov MM, Kazantseva PV, Doroshenko AV, Garbukov EY, Frolova IG, Slonimskaya EM. Amplifications of Stemness Gene Loci—New Markers for the Determination of the Need for Neoadjuvant Chemotherapy for Patients with Breast Cancer. A Prospective Study. Journal of Personalized Medicine. 2021; 11(5):397. https://doi.org/10.3390/jpm11050397
7. Ibragimova M.K., Kokorina E.V., TsyganovM.M, Churuksaeva O.N., Litviakov N.V. Human papillomavirus and ovarian cancer (review of literature and meta-analysis) // Infection, Genetics and Evolution.- Available online 15 September 2021.- https://doi.org/10.1016/j.meegid.2021.105086
8. Bychkov V.A., Pevzner A.M., Nebova J.A., Ermakova N.N., Ibragimova M.K., Tsyganov M.M., Lyapunova L.S., Litviakov N.V. In vitro modeling of tumor interclonal interactions using breast cancer cell lines. Experimental Oncology. 2021; 43(2):118-24.- doi: 10.32471/exp-oncology.2312-8852.vol-43-no-2.16142
9. Pevzner A.M., Gaptulbarova K.A., Tsyganov M.M., Ibragimova M.K., Vvedensky A.V., Zhusina Y.G., Pyankov D.V., Korostylev S.A., Litviakov N.V. Investigation of somatic PIK3CA gene mutations in breast cancer patients. Journal of B.U.ON.. 2021; 26(3):747-52. doi нет
10. Ibragimova, M.K.; Tsyganov, M.M.; Litviakov, N.V. Molecular-Genetic Portrait of Breast Cancer with Triple Negative Phenotype. Cancers 2021, 13, 5348. https://doi.org/10.3390/cancers13215348
11. Alina M. Pevzner, Matvey M. Tsyganov, Marina K. Ibragimova, Nikolai V. Litvyakov Abscopal effect in the radio and immunotherapy// Radiation Oncology Journal 2021 Published online: October 25, 2021 DOI: https://doi.org/10.3857/roj.2021.00115
12. Litviakov N.V., Ibragimova M.K., Tsyganov M.M., Shpileva O.V., Churuksaeva O.N., Kolomiets L.A. Changes in the genetic landscape during the malignization of high grade squamous intraepithelial lesion into cervical cancer // Current Problems in Cancer.- 2020.- Volume 44, Issue 5, October 100567 https://doi.org/10.1016/j.currproblcancer.2020.100567 Q1 IF=3.303
13. Litviakov N.V., Ibragimova M.K., Tsyganov M.M., Doroshenko A.V., Garbukov Eu.Yu. and Slonimskaya E.M. Neoadjuvant Chemotherapy Induces the Appearance of New Copy Number Aberrations in Breast Tumor and is Associated with Metastasis// Current Cancer Drug Targets, 2020 Vol.20, issue 9, pages 681-688, doi 10.2174/1568009620666200506104523, (Q1 IF=2.750)
14. Litviakov N., Ibragimova M., Tsyganov M., Kazantseva P., Deryusheva I., Pevzner A., Doroshenko A., Garbukov E., Tarabanovskaya N., Slonimskaya E. Amplifications of stemness genes and the capacity of breast tumors for metastasis. Oncotarget. 2020; 11: 1988-2001. Retrieved from https://www.oncotarget.com/article/27608/text/ https://doi.org/10.18632/oncotarget.27608 27608 (Q1 IF=3.765)
15. Sigin V.O., Kalinkin A.I., Kuznetsova E.B., Simonova O.A., Chesnokova G.G., Litviakov N.V., Slonimskaya E.M., Tsyganov M.M., Ibragimova M.K., Volodin I.V., Vinogradov I.I., Vinogradov M.I., Vinogradov I.Y., Kutsev S.I., Strelnikov V.V., Zaletaev D.V., Tanas A.S. DNA methylation markers panel can improve prediction of response to neoadjuvant chemotherapy in luminal B breast cancer// Scientific reports. -2020.- 10(1).- P.9239. https://doi.org/10.1038/s41598-020-66197-1 (Q1 IF=4.729)
16. Pevzner Alina, Tsyganov Matvey, Ibragimova Marina, Zarubin Alexey, Litviakov Nikolay Mutations of BRCA1 gene in a tumor tissue and effectiveness of preoperative taxotere therapy in patients with luminal B breast cancer// Gene Reports.- 2020, 100859, https://doi.org/10.1016/j.genrep.2020.100859. Q4
17. Tsyganov, M.M., Rodionov, E.O., Pevzner, A.M., Ibragimova, M.K., Miller, S.V., Cheremisina, O.V., Frolova, I.G., Tuzikov, S.A., Litviakov, N.V. Prognostic significance of ERCC1, RRM1, TOP1, TOP2A, TYMS, TUBB3, GSTP1 and BRCA1 mRNA expressions in patients with non-small-cell lung cancer receiving a platinum-based chemotherapy// Journal of B.U.ON., 2020: 25 (4), pp. 1728-1736.
18. Litviakov N.V., Ibragimova M.K., Tsyganov M.M., Deriusheva I.V., Pevsner A.M., Garbukov E.Yu., Doroshenko A.V., Slonimskaya E.M. Assocıatıon of the combınatıon of stemness gene amplıfıcatıons and Copy Number Aberratıons of WNT-sıgnalıng genes ın breast tumors wıth metastasıs. Siberian journal of oncology. 2020;19(3):78-88. https://doi.org/10.21294/1814-4861-2020-19-3-78-88
19. Tsyganov M.M., Ibragimova M.K., Pevzner A.M., Litviakov N.V. Loss of heterozygosity in the BRCA1 and BRCA2 locus in breast cancer. Siberian Journal of Oncology. 2020; 19(3): 97–101. – doi: 10.21294/1814-4861-2020-19-3-97-101.
20. Litviakov N.V., Bychkov V.A., Stakheeva M.N., Ibragimova M.K., Tsyganov M.M., Gaptulbarova X.A., Tashireva L.A., Bondar L.N., Garbukov E.Yu., Slonimskaya E.M. Breast tumour cell subpopulations with expression of the Myc and Oct4 proteins //Journal of Molecular Histology.- (2020) 51:717–728 DOI10.1007/s10735-020-09917-1 Q2 IF=2.576
21. Gaptulbarova K.A., Tsyganov M.M., Pevzner A.M., Ibragimova M.K., Litviakov N.V. NF-kB as a potential prognostic marker and a candidate for targeted therapy of cancer// Experimental oncology.- 2020.- 42, 4, 263–269.- DOI: 10.32471/exp-oncology.2312-8852.vol-42-no-4.15414
22. Tanas A.S., Sigin V.O., Kalinkin A.I., Litviakov N.V., Slonimskaya E.M., Ibragimova M.K., Ignatova E.O., Simonova O.A., Kuznetsova E.B., Kekeeva T.V., Larin S.S., Poddubskaya E.V., Trotsenko I.D., Rudenko V.V., Karandasheva K.O., Petrova K.D., Tsyganov M.M., Deryusheva I.V., Kazantseva P.V., Doroshenko A.V., Tarabanovskaya N.A., Chesnokova G.G., Sekacheva M.I., Nemtsova M.V., Izhevskaya V.L., Kutsev S.I., Zaletaev D.V. & Strelnikov V.V. Genome-wide methylotyping resolves breast cancer epigenetic heterogeneity and suggests novel therapeutic perspectives //Epigenomics. -2019 V.11:6.- P.605-617. Published Online:7 Feb 2019https://doi.org/10.2217/epi-2018-0213 Q1
23. Tsyganov, MM, Pevzner AM, Ibragimova MK, Deryusheva IV, Litviakov NV. Human Papillomavirus and Lung Cancer: An Overview and a Meta-Analysis.// Journal of cancer research and clinical oncology, - 2019: P.1-19. https://doi.org/10.1007/s00432-019-02960-w Q1 Impact Factor 3.282
24. Tsyganov M.M., Ibragimova M.K., Pevzner A.M., Doroshenko A.V., Slonimskaya Е.М., Litviakov N.V. Amplification of stem genes — new potential metastatic markers in patients with an early form of breast cancer// Journal of Korean Medical Science. 2019 Dec 23;34(49):e312; DOI: 10.3346/jkms.2019.34.e312 Q2
25. Khalyuzova M.V., Litviakov N.V., Takhauov R.M., Isubakova D.S., Usova T.V., Bronikovskaya E.V., Takhauova L.R., Karpov A.B. Delayed Changes in the Frequency of Unstable Chromosomal Aberrations and the CNA-Genetic Landscape of Blood Leukocytes in People Exposed to Long-Term Occupational Irradiation// Biology Bulletin. - 2019.- 46(11). - P.1503-11. https://doi.org/10.1134/S1062359019110049
26. Ibragimova M., Tsyganov M., Shpileva O., Churuksaeva O., Bychkov V., Kolomiets L., Litviakov N. HPV status and its genomic integration affect survival of patients with cervical cancer //Neoplasma. – 2018.- Vol.65, No.3, p.441-448 DOI:10.4149/neo_2018_170414N277 Q3
27. Litviakov N., Tsyganov M., Larionova I., Ibragimova M., Deryusheva I., Kazantseva P., Slonimskaya E., Frolova I., Choinzonov E., Cherdyntseva N., Kzhyshkowska Julia Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy//Cancer Chemotherapy and Pharmacology. - 2018.- July 2018, Volume 82, Issue 1, P. 99–109 DOI 10.1007/s00280-018-3594-8 Q1
28. Ibragimova, M. K., Tsyganov, M. M., & Litviakov, N. V. Human papillomavirus and colorectal cancer. Medical Oncology, - 2018.- 35(11):140. doi:10.1007/s12032-018-1201-9 (Q1 IF=3.505
29. Liu T., Mitrofanova I., Litviakov N., Riabov V., Zavyalova M., Tsyganov M., Buldakov M., Song Bin, Moganti K., Kazantseva P., Slonomskaya E., Kremmer E., Flatley A., Klüter H., Cherdyntseva N.& Kzhyshkowska J. Tumor-associated macrophages in human breast cancer produce new monocyte attracting and proangiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy.// OncoImmunology, 2018.- DOI: 10.1080/2162402X.2018.1436922 (Impact Factor: 7.719). https://www.tandfonline.com/doi/abs/10.1080/2162402X.2018.1436922
30. Cherdyntseva N.V., Litviakov N.V., Denisov E.V., Gervas P.A., Cherdyntsev E.S. Circulating Tumor Cells in Breast Cancer: Functional Heterogeneity, Pathogenetic and Clinical Aspects // Experimental Oncology.- 2017.- V.39.- N1.- P.2-11 Scopus SJR– 0,95 http://exp-oncology.com.ua/wp/wp-content/uploads/2017/03/2340.pdf?upload=
31. Tsyganov M.M., Freidin M.B., Ibragimova M.K., Deryusheva I.V., Kazantseva P.V., Slonimskaya E.M., Cherdyntseva N.V., Litviakov N.V. Genetic variability in the regulation of the expression cluster of MDR genes in patients with breast cancer.// Cancer Chemotherapy and Pharmacology.- 2017.- August 2017, Volume 80, Issue 2, pp 251–260 doi: 10.1007/s00280-017-3354-1 WOS – 2.737 https://www.researchgate.net/publication/317539246_Genetic_variability_in_the_regulation_of_the_expression_cluster_of_MDR_genes_in_patients_with_breast_cancer
32. Deryusheva I.V., Tsyganov M.M., Garbukov E.Yu., Ibragimova M.K., Kzhyshkovska J.G., Slonimskaya Е.M., Cherdyntseva N.V., Litviakov N.V. Genome-wide association study of loss of heterozygosity and metastasis-free survival in breast cancer patients // Experimental Oncology. -- 2017. -- V. 39 (2). -- P. 145-150. Scopus SJR– 0,95 http://exp-oncology.com.ua/wp/wp-content/uploads/2017/07/23661.pdf?upload=
33. Stakheyeva M, Riabov V, Mitrofanova I, Litviakov N, Choynzonov E, Cherdyntseva N, Kzhyshkowska J. Role of the immune component of tumor microenvironment in the efficiency of cancer treatment: perspectives for the personalized therapy. //Current Pharmaceutical Design 2017 Jul 14. 2017. – Т. 23. – С. 1-20 doi: 10.2174/1381612823666170714161703. [Epub ahead of print] PubMed PMID: 28714406 (WOS 2.611). http://www.eurekaselect.com/154229/article
34. Belyavskaya V.A., Prudnikova T.Y., Domanitskaya N.V., Litviakov N.V., Maksimov V.N., Cherdyntseva N.V., Grigorieva E.V. GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population. // Gene. – 2017. – Т. 628. – С. 224-229 doi.org/10.1016/j.gene.2017.07.054 http://www.sciencedirect.com/science/article/pii/S0378111917305784 (WOS 2.415)
35. Babyshkina N., Vtorushin S., Zavyalova M., Patalyak S., Dronova T., Litviakov N., Slonimskaya E., Kzhyshkowska J., Cherdyntseva N., Choynzonov E. The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen // Clinical and experimental medicine. ‒ 2017, Volume 17, Issue 3, pp 383–393 DOI 10.1007/s10238-016-0428-z WOS IF – 2.854 https://link.springer.com/article/10.1007/s10238-016-0428-z
36. Bychkov V.A., Nikitina E.G., Ibragimova M.K., Kaigorodova E.V., Choinzonov E.L., Litviakov N.V. Comprehensive meta-analytical summary on human papillomavirus association with head and neck cancer// Experimental oncology.- 2016.- V.38 (2).- P.68-72. http://exp-oncology.com.ua/wp/wp-content/uploads/2016/06/2223.pdf?upload=
37. Litviakov N.V., Freidin M.B., Sazonov A.E., Khalyuzova M.V., Buldakov M.A., Karbyshev M.S., Albakh Е.N., Isubakova D.S., Gagarin А.A., Nekrasov G.B. Different Patterns of Allelic Imbalance in Sporadic Tumors and Tumors Associated With Long-Term Exposure to Gamma-Radiation // Mutation Research/Genetic Toxicology and Environmental Mutagenesis. ‒ 2015 794.- P.8-16 doi: 10.1016/j.mrgentox.2015.09.003 (Impact Factor: 2.254) http://www.sciencedirect.com/science/article/pii/S1383571815002284
38. Denisov E.V., Zavyalova M.V., Litviakov N.V., Tsyganov M.M., Kaigorodova E.V., Slonimskaya E.M., Kzhyshkowska J., Cherdyntseva N.V., Perelmuter V.M. Invasive and drug resistant expression profile of different morphological structures of breast tumors.// Neoplasma 2015 (Impact Factor: 1.64).Vol.62.- N 3.- P.401-405; DOI: 10.4149/neo_2015_041 https://www.researchgate.net/profile/Nikolay_Litviakov/publication/272166419_Invasive_and_drug_resistant_expression_profile_of_different_morphological_structures_of_breast_tumors/links/56af8c1c08ae9c1968b45b2e.pdf
39. Takhauov R.M., Karpov A.B., Albach E.N., Khalyuzova M.V., Freidin M.B., Litviakov N.V., Sazonov A.E., Isubakova D.S., Bolshakov M.A., Mezheritskiy S.A., Mironova E.B., Semenova J.V., Nekrasov G.B., Izosimov A.S., Gagarin A.A., Brendakov R.V., Maksimov D.E., and Ermolaev Yu.D. The Bank of Biological Samples Representing Individuals Exposed to Long-Term Ionizing Radiation at Various Doses // Biopreservation and Biobanking 2015. ‒ V. 13, N 2. ‒ P. 72-78. - DOI: 10.1089/bio.2014.0035 (Impact Factor: 1.804) http://online.liebertpub.com/doi/abs/10.1089/bio.2014.0035
40. Vtorushin SV, Khristenko KY, Zavyalova MV, Perelmuter VM, Litviakov NV, Denisov EV, Dulesova AY, Cherdyntseva NV. The phenomenon of multi-drug resistance in the treatment of malignant tumors.// Experimental Oncology.- 2014 Sep;36(3):144-156. PubMed PMID: 25265346. http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?C21COM=2&I21DBN=UJRN&P21DBN=UJRN&IMAGE_FILE_DOWNLOAD=1&Image_file_name=PDF/EOL_2014_36_3_3.pdf
41. Denisov E.V., Litviakov N.V., Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Tsyganov M.M., Gerashchenko T.S., Garbukov E.Y., Slonimskaya E.M., Cherdyntseva N.V. Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression.//Scientific reports.- 2014 - N4. 4709.- P.1-7. doi:10.1038/srep04709 (Impact Factor: 5.578) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988480/
42. Volkomorov V., Grigoryeva E., Krasnov G., Litviakov N., Tsyganov M., Karbyshev M., Zavyalova M., Afanasуev S., Cherdyntseva N., Lisitsyn N. Search for potential gastric cancer markers using miRNA databases and gene expression analysis // Experimental Oncology. 2013. V. 35. N 1. – P.2-7 http://www.nbuv.gov.ua/old_jrn/chem_biol/eol/2013_1/002.pdf
43. Zavyalova M.V., Denisov E.V., Tashireva L.A., Geraschenko T.S., Litviakov N.V., Skryabin N.A., Vtorushin S.V., Telegina N.S., Slonimskaya E.M., Cherdyntseva N.V., Perelmuter V.M. Phenotypic Drift as a Cause for Intratumoral Morphological Heterogeneity of Invasive Ductal Breast Carcinoma Not Otherwise Specified.//BioResearch Open Access.- 2013-Apr;2(2):148-54.- DOI: 10.1089/biores.2012.0278 (Impact Factor: 1.421) http://online.liebertpub.com/doi/abs/10.1089/biores.2012.0278
44. Litviakov N.V., Cherdyntseva N.V., Tsyganov M.M., Denisov E.V., Garbukov E.Y., Merzliakova M.K., Volkomorov V.V., Vtorushin S.V., Zavyalova M.V., Slonimskaya E.M., Perelmuter V.M. Changing the expression vector of multidrug resistance genes is related to neoadjuvant chemotherapy response. //Cancer Chemotherapy and Pharmacology, 2013, Vol.71 N.1 P.153-163. DOI: 10.1007/s00280-012-1992-x (Impact Factor: 2.824) http://link.springer.com/article/10.1007/s00280-012-1992-x https://www.researchgate.net/profile/Nikolay_Litviakov/publication/232229957_Changing_the_expression_vector_of_multidrug_resistance_genes_is_related_to_neoadjuvant_chemotherapy_response/links/00b4952f9c5195383a000000.pdf
45. Cherdyntseva NV, Denisov EV, Litviakov NV, Maksimov VN, Malinovskaya EA, Babyshkina NN, Slonimskaya EM, Voevoda MI, Choinzonov EL: Crosstalk Between the FGFR2 and TP53 Genes in Breast Cancer: Data from an Association Study and Epistatic Interaction Analysis.// DNA and Cell Biology 2012, 31(3):306-316. doi:310.1089/dna. (Impact Factor: 2.334) https://www.researchgate.net/profile/Vladimir_Maximov3/publication/233855450_1._Cherdyntseva_N.V._Denisov_E.V._Litviakov_N.V._Maksimov_V.N._Malinovskaya_E.A._Babyshkina_N.N._Slonimskaya_E.M._Voevoda_M.I._Choinzonov_E.L._Crosstalk_between_the_FGFR2_and_TP53_genes_in_breast_cancer_data_from_an_association_study_and_epistatic_interaction_analysis._DNA_Cell_Biol._2012._31(3)_306-316/links/54e6d8ae0cf2cd2e0290a43f.pdf
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49. Denisov E.V., Sukhanovskaya T.V., Dultseva T.S., Malinovskaya E.A., Litviakov N.V., Slonimskaya E.M., Choinzonov E.L., Cherdyntseva N.V. Coordination of TP53 Abnormalities in Breast Cancer: Data from Analysis of TP53 Polymorphisms, Loss of Heterozygosity, Methylation, and Mutations // Genetic Testing and Molecular Biomarkers. December 2011, 15(12): 901-907. doi:10.1089/gtmb.2011.0038. https://www.researchgate.net/publication/51541098_Coordination_of_TP53_Abnormalities_in_Breast_Cancer_Data_from_Analysis_of_TP53_Polymorphisms_Loss_of_Heterozygosity_Methylation_and_Mutations
50. Cherdyntseva N.V., Gervas P.A., Litvyakov N.V., Stakcheeva M.N., Ponomareva A.A., Dobrodeev A.Yu., Denisov E.V., Belyavskaya V.A., Choinzonov E.L. Age-related function of tumor suppressor gene TP53: contribution to cancer risk and progression.//Experimental oncology. 2010. – Vol. 32., Spl. – P. 205 - 208. http://exp-oncology.com.ua/wp/wp-content/uploads/magazine/869.pdf?upload=
51. Litviakov N.V., Denisov E.V., Takhauov R.M., Karpov A.B., Skobel’skaja E.V., Vasil’eva E.O., Goncharik O.O., Ageeva A.M., Mamonova N.V., Mezheritskiy S.A., Sevost’janova N.V., Koshel A.P. Association Between TP53 Gene ARG72PRO Polymorphism and Chromosome Aberrations in Human Cancers.// Molecular Carcinogenesis 2010.- 49:P.521– 524. (Impact Factor: 4.770) https://www.researchgate.net/publication/44640015_Association_Between_TP53_Gene_ARG72PRO_Polymorphism_and_Chromosome_Aberrations_in_Human_Cancers
52. Denisov E.V., N.V. Cherdyntseva, N.V. Litvjakov, E.A. Malinovskaya, M.I. Voevoda, V.A. Belyavskaya, V.N. Stegniy TP53 mutations and Arg72Pro polymorphism in breast cancer patients’ tumors // Cancer Genetics and Cytogenetics. – 2009. – Vol.192. – P.93-95. https://www.researchgate.net/publication/26664994_TP53_mutations_and_Arg72Pro_polymorphism_in_breast_cancers
53. Buldakov M.A., Hassan M.A., Qing-Li Zhao,. Feril L.B Jr., Kudo N., Kondo T., Litvyakov N.V., Bolshakov M.A., Rostov V.V., Cherdyntseva N.V., Riesz P. Influence of changing pulse repetition frequency on chemical and biological effects induced by low-intensity ultrasound in vitro.// Ultrasonics Sonochemistry 16 (2009) 392–397 https://www.researchgate.net/publication/23486731_Influence_of_changing_pulse_repetition_frequency_on_chemical_and_biological_effects_induced_by_low-intensity_ultrasound_in_vitro?ev=prf_pub
54. Svetlana N. Tamkovich, Nikolai V. Litviakov, Olga E. Bryzgunova, Aleksey Yu. Dobrodeev, Elena Yu. Rykova, Sergey A. Tuzikov, Aleksandr A. Zav’ialov, Valentin V. Vlassov, Nadezhda V. Cherdyntseva, and Pavel P. Laktionov. Cell-Surface-Bound Circulating DNA as a Prognostic Factor in Lung Cancer.// Ann. N.Y. Acad. Sci. 2008.- 1137: P.214–217. https://www.researchgate.net/publication/23302401_Cell-Surface-Bound_Circulating_DNA_as_a_Prognostic_Factor_in_Lung_Cancer
55. Litvyakov N.V., Rostov V.V., Bol’shakov M.A., Buldakov M.A., Afanas’ev K.V., Astapenko A.N., Kutenkov O.P., and N.V. Cherdyntseva Apoptosis-Inducing Effect of Pulse Periodic X-rays on Tumor Cells// Biophysics ISSN 0006-3509, Vol. 50, Suppl. 1, 2005, p. S51-S58. The supplement is published only in English by MAIK “Nauka/ Interperiodica” (Russia). https://www.researchgate.net/publication/249998615_Apoptosis-inducing_effect_of_pulse_periodic_X-rays_on_tumor_cells