Personalities

Marina N. Stakheyeva

Marina N. Stakheyeva, MD, PhD, Leading Researcher of the Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk NRMC.

Contact details

e-mail: stakheyevam@oncology.tomsk.ru
tel.: 8 (3822) 41-80-79

SPIN-код,  7804-0361

РИНЦ AuthorID, 183824

ResearcherID Web of Science, C-6184-2012

Scopus (Author ID), 6505941716

ORCID. 0000-0003-0601-2240

Brief Biography

Work experience

2015 – Present: Leading Researcher of the Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk NRMC
2017-Present: Senior Researcher, Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University

2018-Present: Professor, Department of Biochemistry and Molecular Biology with course of Clinical Laboratory Diagnostics, Sibeirian State Medical University

2015-2017: Leading Researcher, Laboratory investigation of mechanisms of signal transduction, RASA-center in Tomsk, Tomsk Polytechnic University

1999 –2015: Senior Researcher, Laboratory of Molecular Oncology and Immunology,

1993-1999: Researcher, Laboratory of Immunopharmacology, Pharmacology Research Institute, SB RAMS

1989-1993: Junior Researcher, Laboratory of oncopharmacology, Pharmacology Research Institute, SB RAMS

1989-1988: Junior Researcher, Department of Planning and Coordination of Scientific Researches, Cancer Research Institute, TSC AMS USSR

Education

2011: MD in Pathological Physiology and Oncology, Pharmacology Research Institute, SB RAMS
1991-1993: PhD in Pharmacology and Pathological Physiology, Pharmacology Research Institute, SB RAMS
1982-1988: Specialist in Biolphisics, Tomsk Medical State Institute

Research Interests

• oncoimmunology
• prognosis of cancer outcome and cancer therapy efficiency
• immunological mechanisms (checkpoints) as targets for cancer therapy

Projects

M.N. Stakheyeva is involved in the following projects:

• “Genomic mechanisms of regulation of tumor progression of breast cancer in drug therapy” (RFBR, 2018-2020)
• “The role of programming of monocytes in the formation of pro- and antitumor phenotypes of tumor-associated macrophages and effectiveness chemotherapy for colorectal cancer” (RFBR, 2018-2021)
• “Metastatic clones of breast cancer” (RSF, 2019-2020)
• “Search for biomarkers and therapeutic targets in the processes of chronic inflammation associated with the progression of malignant neoplasms, regenerative processes of cardiovascular diseases and implantology” (2018-2020)
• “The study of the physicochemical laws of NO metabolites in biological objects as biomarkers of cancer” (2017-2019)
• “The relationship of the phenotypic profile of monocyte-macrophage lineage cells with the risk of progression of non-small cell lung cancer in patients with various types of pre-tumor changes in the respiratory epithelium” (RFBR, 2020-2022)

Awards

Badge of Honored Veteran of the SB RAS (2019)

Department of Health of the Tomsk Region Award (2014)

Diploma I degree of invest session «Bridge to success»of Innovation Forum Innovus in Tomsk for project “Creation of soft for malignant tumor prognosis”, (2011)

Publications

M.N. Stakheyeva is an author of more than 170 publications (including 2 book, and 49 peer-reviewed papers), 4 Russian patents. 

1. Litviakov N. V., Bychkov V. A., Stakheeva M. N., Ibragimova M. K., Tsyganov M. M., Gaptulbarova K. A., Tashireva L. A., Bondar L. N., Garbukov E. Y., Slonimskaya E. M. Breast tumour cell subpopulations with expression of the MYC and OCT4 proteins. Journal of Molecular Histology. 2020. doi: 10.1007/s10735-020-09917-1.

2. Popova, V., Korotkova, E., Barek, J., Stakheyeva, M., Fedorov, A., Patysheva, M., Cheremisina, O. Evaluation of human macrophage functional state by voltammetric monitoring of nitrite ions. Analytical and Bioanalytical Chemistry. 2020; 412(21): 5097-5104. doi: 10.1007/s00216-020-02399-w

3. Larionova, G.Tuguzbaeva, A.Ponomareva, M.Stakheeva, N.Cherdyntseva, V.Pavlov, E.Choinzonov, J.Kzhyshkovska. TUMOR-ASSOCIATED MACROPHAGES IN HUMAN BREAST, COLORECTAL, LUNG, OVARIAN AND PROSTATE CANCERS. // 2020. Front. Oncol. Vol. 10. | doi: 10.3389/fonc.2020.566511
4. Christopher M. Massa 1, Ziping Liu 1, Sheryse Taylor 1, Ashley P. Pettit 1, Marena N. Stakheyeva 2,3, Elena Korotkova 3, Valentina Popova 3, Elena Atochina-Vasserman 2,4, Andrew J. Gow. Biological Mechanisms of S-Nitrosothiol Formation and Degradation: How Is Specificity of S-Nitrosylation Achieved? Antioxidants 2021, 10, 1111. https:// doi.org/10.3390/antiox10071111.
5. M. Patysheva, M. Stakheyva, I.Larionova, A.Fedorov, J. Kzhyshkowska, N. Cherdyntseva. CYTOSTATIC CANCER THERAPY MODULATES MONOCYTES-MACROPHAGE CELL FUNCTIONS: HOW IT IMPACT ON TREATMENT OUTCOMES // Experimental oncology. 2019. Т.41. № 3. С. 248-253.
6. Stakheyeva M., Eidenzon D., Slonimskaya E., Patysheva M., Bogdashin I., Kolegova E., Grigoriev E., Choinzonov E., Cherdyntseva N. Integral characteristic of the immune system state predicts breast cancer outcome // Experimental Oncology. 2019. Т.41. № 1. С. 32-38.
7. Popova V., Korotkova E., Barek J., Stakheyeva M., Fedorov A., Patysheva M., Cheremisina O. Evaluation of human macrophage functional state by voltammetric monitoring of nitrite ions // Analytical and Bioanalytical Chemistry. -https://doi.org/10.1007/s00216-020-02399-w
8. Yunusova Natalia V., Stakheyeva Marina N., Molchanov Sergey V., Afanas ’ev Sergey G., Tsydenova Anastasia A. , Kolomiets Larisa A., CherdyntsevaNadejda V. Functional activity of natural killer cells in biological fluids in patients with colorectal and ovarian cancers // Central European Journal of Immunology 2018; 43(1). - DOI: https://doi.org/10.5114/ceji.2018.74870
9. Kaigorodova E. V., Tarabanovskaya N. A., Staheeva M. N., Savelieva O. E., Tashireva L. A., Denisov E. V., Perelmuter V. Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients // Neoplasma. – 2017. – V. 64, 3/ - 437-443. - doi:10.4149/neo_2017_315
10. Stakheyeva M, Riabov V, Mitrofanova I, Litviakov N, Choynzonov E, Cherdyntseva N, Kzhyshkowska J. Role of the immune component of tumor microenvironment in the efficiency of cancer treatment: perspectives for the personalized therapy // Curr Pharm Des. 2017. Т.23. № 32. С. 4807-4826. doi: 10.2174/1381612823666170714161703. https://www.ncbi.nlm.nih.gov/pubmed/28714406
11. Stakheyeva M., Eidenzon D., Cherdyntseva N., Slonimskaya E., Cherdyntsev E. Multidimensional Visualization for the Immune System State Presentation in Breast Cancer Patients // AIP Conf. Proc. – 2015. – Vol. 1688. 080003-1–080003-4. - New Operational Technologies (NEWOT’2015): proceedings of the 5th International Scientific Conference. 29–30 September. Tomsk, Russia 2015. - doi: 10.1063/1.4936066.
12. Dygai, A.M., Skurikhin, E.G., Pershina, O.V., Ermakova, N.N., Krupin, V.A., Ermolaeva, L.A., Stakheeva, M.N., Choinzonov, E.L., Goldberg, V.E., Reikhart, D.V., Ellinidi, V.N., Kravtsov, V.Y. Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus // Bulletin of Experimental Biology and Medicine, 2016. pp. 1-6.  DOI: 10.1007/s10517-016-3200-1.
13. Stakheeva MN The role of the immune system in the pathogenesis of breast cancer: the formation and implementation of antitumor and tumor-stimulating strategies. Saarbrucken, Deutschland: LAP LAMBERT Academic Publishing. - 2014 .-- 184 p. ISBN: 978-3-659-56551-9
14. Kzhyshkovska Yu.G., Stakheeva M.N., Litvyakov N.V., Savelyeva O.E., Mitrofanova I.V., Stepanov I.V., Grachev A.N., Gerashchenko T.S., Zavyalova M .V., Cherdyntseva N.V. The immune system and the effectiveness of antitumor treatment. Tomsk - Publishing house of Tomsk State University. - 2015 .-- 164 p. ISBN 978-5-7511-2391-8