Personalities

Liudmila V. Spirina

Liudmila V. Spirina, Doctor of Medical Sciences, Leader Researcher, Laboratory of Tumor Biochemistry, Cancer Research Institute, Tomsk National Research Medical Center.

Contact details

e-mail: spirinalv@oncology.tomsk.ru
tel.: 8 (3822) 51-45-98
fax: 8 (3822) 51-40-97

Brief Biography

Spirina L. graduated from the Medico-Biological Faculty of the Siberian State Medical University, Tomsk (SSMU)In 2001. Since 2001 till 2003 she had a postgraduate study in the Department of Biochemistry and Molecular Biology and got a PhD. Since 2003 till 2006 she worked in the Medical Clinic in Khabarovsk region. Since 2006, Spirina L.V. had a position of a senior researcher in the Laboratory of Tumor Biochemistry in the Cancer Research Institute of the Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences. She completed the residency of Clinical Laboratory Diagnostic in Siberian State Medical University. In 2013 she got degree of Doctor of Medicine. From 2014 till present time she is a professor in the Department of Biochemistry and Molecular Biology with a course in Clinical Laboratory diagnostics in the SSMU.

Research Interests

L.V. Spirina is the author of more than 130 published works, including the monograph "Squamous cell carcinoma of the head and neck: the molecular basis of pathogenesis."

The main scientific interests are molecular markers of development and progression of malignant neoplasms. The main subject of scientific work is the conduct of fundamental research on the role of proteolytic enzymes in the development of malignant neoplasms. Spirina L.V. has received important results both for understanding the patterns of tumor growth, and in practice for the formation of high-risk groups and evaluating the prognosis of malignant tumors. Currently she develops molecular approaches for the optimal choice of targeted drugs in patients with disseminated kidney cancer.

Achievements, awards, and grants 

Dr. Spirina participates in research projects, such as RFBR projects (RFBR, №13-04-00169, №14-04-91150 GFEN_а), Federal Target Program "Scientific and scientific-pedagogical personnel of innovative Russia" in 2009-2013; President Grant.

The experience in project of investigation of biologically active molecules in the development of malignant tumors. There were obtained novel data on the proteolytic regulation of growth and transcription factors in tissues of squamous cell head and neck cancer, renal cancer, endometrial, breast. Based on the study of molecular indicators have been developed unique patent of the development of lymph node metastases in cancer of the head and neck prognosis (RF patent №2527338, №2426991), of the development of haematogenous metastases in kidney cancer prognosis (RF patent № 2528100), of the outcome prognosis of bladder cancer patients (RF patent №2538632) and assess the risk of endometrial cancer in patients with endometrial hyperplasia (RF patent № 2554505). 

Main Publications

1. Spirina L.V., Yunusova NV, Kolomiets LA, Koval VD, Chernyshova AL, Shpileva OV Association of growth factors, HIF-1 and NF-kB expression with proteasomes in endometrial cancer. Mol Biol Rep 2012 -39(9):8655-62. http://link.springer.com/article/10.1007/s11033-012-1720-y

2. Tarasenko N.V., Spirina L.V., Usynin E.A., Gorbunov A.K. Genetic aspects of prostate cancer development // /«Cellular and molecular mechanism of tumour–microenvironment crosstalk». Abstract. 2015. p. 86-87. doi:10.1016/j.ejcsup.2015.08.108

3. Liudmila V. Spirina, Evgeny A. Usynin, Irina V. Kondakova, Zahar A. Yurmazov, Elena M. Slonimskaya Molecular Markers of Kidney Cancer Progression, Association with Efficiency of Pazopanib Therapy // J. Biomedical Science and Engineering, 2015, 8, 756-766

4. Spirina L. V., Usynin Y. A, Kondakova I. V., Yurmazov Z. A., Slonimskaya E. M., Kolegova E. S. The AKT-mTOR Signalling Pathway in Kidney Cancer Tissues // AIP Conf. Proc. – 2015. – Vol. 1688. 080004-1–080004-5. - New Operational Technologies (NEWOT’2015): proceedings of the 5th International Scientific Conference.  29–30 September.  Tomsk, Russia 2015. - doi: 10.1063/1.4936067 http://scitation.aip.org/content/aip/proceeding/aipcp/10.1063/1.4936067

5. Spirina L.V., Kondakova I.V., Choynzonov E.L., Chigevskaya S.Y., Shishkin D.A., Kulbakin D.Y. Expression of vascular endothelial growth factor and transcription factors HIF-1, NF-KB expression in squamous cell carcinoma of head and neck; assocation with proteasome and calpain activities // Journal of Cancer Research and Clinical Oncology. 2013. Т. 139. № 4. С. 625-633. http://link.springer.com/article/10.1007%2Fs00432-012-1366-0

6. Spirina LV, Kondakova IV, Tarasenko NV, Slonimskaya EM, Usynin EA, Gorbunov AK, Yurmazov ZA, Chigevskaya SY. Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy-- AKT/m-TOR Pathway and Resistance to Cancer Therapy Zhongguo Fei Ai Za Zhi. 2018 Jan 20;21(1):63-66. doi: 10.3779/j.issn.1009-3419.2018.01.09.

7. Spirina LV, Usynin EA, Yurmazov ZA, Slonimskaya EM, Kondakova IV.Effect of Targeted Therapy With Pazopanib on Expression Levels of Transcription, Growth Factors and Components of AKT/m-TOR Signaling Pathway in Patients with Renal Cell Carcinoma Asian Pac J Cancer Prev. 2017 Nov 26;18(11):2977-2983.

8. Spirina LV, Usynin YA, Yurmazov ZA, Slonimskaya EM, Kolegova ES, Kondakova IV. Transcription factors NF-kB, HIF-1, HIF-2, growth factor VEGF, VEGFR2 and carboanhydrase IX mRNA and protein level in the development of kidney cancer metastasis.Mol Biol (Mosk). 2017 Mar-Apr;51(2):372-377. doi: 10.7868/S0026898417020197. Russian.

9. Yunusova NV, Villert AB, Spirina LV, Frolova AE, Kolomiets LA, Kondakova IV.Insulin-Like Growth Factors and Their Binding Proteins in Tumors and Ascites of Ovarian Cancer Patients: Association With Response To Neoadjuvant Chemotherapy. Asian Pac J Cancer Prev. 2016 Dec 1;17(12):5315-5320.

10. Yunusova NV, Spirina LV, Frolova AE, Afanas'ev SG, Kolegova ES, Kondakova IV. Association of IGFBP-6 Expression with Metabolic Syndrome and Adiponectin and IGF-IR Receptor Levels in Colorectal Cancer. Asian Pac J Cancer Prev. 2016;17(8):3963-9.

11. Spirina LV, Usynin EA, Kondakova IV, Yurmazov ZA, Slonimskaya EM. Effect of Target Therapy on the Content of Transcription and Growth Factors, Protein Kinase TOR, and Activity of Intracellular Proteases in Patients with Metastatic Renal Cell Carcinoma. Bull Exp Biol Med. 2016 Apr;160(6):798-801. doi: 10.1007/s10517-016-3313-6. Epub 2016 May 10.

12. Kondakova IV, Iunusova NV, Spirina LV, Kolomiets LA, Villert AB.[Association of intracellular proteinase activities with the content of locomotor proteins in tissues of primary tumors and metastasis in ovarian cancer]. Bioorg Khim. 2014 Nov-Dec;40(6):735-42. Russian.

13. Kondakova IV, Spirina LV, Koval VD, Shashova EE, Choinzonov EL, Ivanova EV, Kolomiets LA, Chernyshova AL, Slonimskaya EM, Usynin EA, Afanasyev SG. [Chymotripsin-like activity and subunit composition of proteasomes in human cancers].Mol Biol (Mosk). 2014 May-Jun;48(3):444-51. Russian.

14. Iunusova NV, Spirina LV, Kondakova IV, Kolomiets LA, Villert AE, Shpileva OV.[Expression and activity of proteases in metastasis of ovarian cancer]. Izv Akad Nauk Ser Biol. 2014 Sep-Oct;(5):448-55. Russian.

15. Choĭnzonov EL, Spirina LV, Kondrakova IV, Shishkin DA, Chizhevskaia SIu. [Expression of the transcription factors NF-kappaB and HIF-1 in squamous cell carcinomas of the head and neck: association with disease prognosis]. Vopr Onkol. 2013;59(5):575-9. Russian.