Personalities

Evgenia V. Kaigorodova

Evgenia V. Kaigorodova, MD, PhD, Leading Researcher, Department of General and Molecular Pathology, Cancer Research Institute of Tomsk NRMC, Professor of the Department of Biochemistry and Molecular Biology with the Course of Clinical Laboratory Diagnostics, Siberian State Medical University (Tomsk, Russia).

Contact information

e-mail: kaigorodova@oncology.tomsk.ru
tel.: +7 (3822) 41-80-71

Brief Biography

Evgenia V. Kaigorodova graduated from the Medical-Biological Faculty of Siberian State Medical University. From 2005 to 2008, she received postgraduate training at the Pathophysiology Department of Siberian State Medical University. In 2008, she successfully defended her PhD thesis. She completed an internship in the field of clinical laboratory diagnostics. She was appointed to head the scientific and educational center of molecular medicine at Siberian State Medical University. In 2012, she received DSc degree for her dissertation titled “Molecular mechanisms of the regulatory effect of heat shock proteins on apoptosis of tumor cells” and worked at the Department of Pathologic Anatomy and Cytology of the Cancer Research Institute as a research fellow and physician of clinical laboratory diagnostics. In 2013, she had advanced training in immunohistochemical and molecular biological diagnosis at P.A. Herzen Moscow Research Institute of Oncology (Moscow). Since 2014, she has been a Leading Researcher at the Department of Pathologic Anatomy and Cytology of the Cancer Research Institute. In 2014, she was awarded the rank of Professor at the Department of Biochemistry and Molecular Biology with the Course of Clinical Laboratory Diagnostics of Siberian State Medical University. Since 2014, E.V. Kaigorodova has been a Leading Researcher of the Laboratory of of Translational Cellular and Molecular Biomedicine of Tomsk State University.In 2017 she received the rank of associate professor in the specialty "molecular biology".

Research Interests

The main research interests include studies in the field of oncology, molecular medicine, immunology, hematology, cytology, clinical laboratory diagnostics and fluorescent in situ hybridization (FISH) testing.  Topics of research works by E.V. Kaigorodova "Development of theoretical foundations and a method for predicting the risk of developing hematogenous metastases in invasive ductal breast cancer" (2014-2019), "Development of minimally invasive approaches for predicting the course of tumors in the female reproductive system".

Evgenia V. Kaigorodova is an author of more than 140 scientific publications, including 82 papers in peer-reviewed journals and 2 books. She  is  also the author of 3 manuals and 2 medical technology.  She has 5 patent, 5 registered databases and 1know-how.  Under the leadership of E.V. Kaigorodova, 1 Ph.D. thesis was defended. 

 https://orcid.org/0000-0003-4378-6915

Web of Science ResearcherID A-5400-2014

Scopus  ID 24778286000

Awards and Grant

E.V. Kaigorodova is actively engaged in her research work. She is the Head of the project within the framework of the Federal Target Program "Scientific and Scientific Pedagogical Staff of Innovative Russia" for 2009-2013 (project №П1203: "Identification of molecular targets for correction of apoptosis disorders in tumor cells"). In 2011, she became the winner of the competition for the grant of the President of the Russian Federation for young scientists (project №16.120.11.480-МК: "Investigation of the molecular mechanisms of the regulatory effect of heat shock proteins on the apoptosis of tumor cells"), as well as the grant from Carl Zeiss "Modulation of apoptosis of tumor and normal lymphocytes by inhibitors of heat shock proteins".  In 2014 she won the grant of the President of the Russian Federation "Development of new approaches to predicting the response to cancer therapy (breast cancer, squamous cell carcinoma of the larynx and hypopharynx) based on the use of chaperones as molecular markers" (No. MD-168.2014.7). In 2015, under supervision of E.V. Kaygorodova, the grant of the Russian Foundation for Basic Research titled "Studying the parameters of the tumor niche as prognostic markers of breast cancer metastasis" was won (Agreement No. 15-34-20864 \ 15). In 2018, she won the grant of the President of the Russian Federation titled "Development of new minimally invasive approaches  for cancer prediction (breast and ovarian cancer) based on the evaluation of various populations of circulating tumor cells as liquid biopsy markers" (MD 544.2018.7).

Evgenia V. Kaygorodova is a Laureate of the Tomsk Oblast Prize in Education, Science, Health and Culture (2011), Laureate of the Tomsk Oblast Legislative Duma Prize in the nomination "Natural Sciences" (2013), Laureate of the Tomsk Oblast Prize in Education, Science, Healthcare and Culture (2016). She was awarded with the Certificate of Honor of the Administration of the Tomsk region for her great contribution to the development of scientific research, the training of highly qualified specialists and with the Day of Russian Science (2018). Evgenia V. Kaigorodova is the clinical trial leader NCT04817501 Phenotypic Spectrum of CTCs in Tumors of the Female Reproductive System (CTCs). In 2020, the winner of the grant of the President of the Russian Federation for doctors of science "Studies of the phenotypic spectrum and the number of different populations of circulating tumor cells as markers of liquid biopsy in malignant neoplasms of the reproductive system in women" (MD-217.2020.7).

Main Publications

1. The presence of various populations of circulating tumor cells in the blood of breast cancer patients before treatment: Association with five-year metastasis-free survival Kaigorodova, E.V., Tarabanovskaya, N.A., Surkova, P.V., Zelchan, R.V., Garbukov, E.Y. Siberian Journal of Oncology, 2020, 19(6): 57–65 DOI 10.21294/1814-4861-2020-19-6-57-65
2. Kaigorodova E.V., Fedulova N.V., Ochirov M.O., Dyakov D.A., Molchanov S.V., Chasovskikh N.Yu. Dissimilar tumor cell populations in ascitic fluid of ovarian cancer patients. Bulletin of Siberian Medicine. 2020;19(1):50-58. https://doi.org/10.20538/1682-0363-2020-1-50-58 
3. Heterogeneity of Circulating Tumor Cells in Neoadjuvant Chemotherapy of Breast Cancer. Kaigorodova EV, Savelieva OE, Tashireva LA, Tarabanovskaya NA, Simolina EI, Denisov EV, Slonimskaya EM, Choynzonov EL, Perelmuter VM. Molecules. 2018 Mar 22;23(4). pii: E727. doi: 10.3390/molecules23040727.  
4. RELATIONSHIP BETWEEN THE LEVEL DIFFERENT POPULATIONS OF CIRCULATING TUMOR CELLS BEFORE TREATMENT AND EFFEC TO NEOADJUVANT CHEMOTHERAPY IN PATIENTS WITH BREAST CANCER Kaigorodova E.V., Tarabanovskaya N.A., Simolina E.I., Perelmuter V.M. В сборнике: The 22nd International Charles Heidelberger Symposium on Cancer Research Proceedings of the International Symposium. 2018. С. 37-38
5. CXCR4 EXPRESSION IN DIFFERENT SUBSETS OF CTCS AND SINGLE (DETACHED) BREAST CANCER CELLS Savelieva O.E., Tashireva L.A., Buldakov M.A., Mukhamedzhanov R.H., Kaigorodova E.V., Denisov E.V., Zavyalova M.V., Perelmuter V.M. Сибирский онкологический журнал. 2018. Т. 17. № 4. С. 75-80.
6. Kaigorodova E.V. CIRCULATING TUMOR CELLS: CLINICAL SIGNIFICANCE IN BREAST CANCER (REVIEW). Annals of the Russian academy of medical sciences. 2017;72(6):450-457. (In Russ.) DOI:10.15690/vramn833
7. Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients. Kaigorodova EV, Tarabanovskaya NA, Staheeva MN, Savelieva OE, Tashireva LA, Denisov EV, Perelmuter VM. Neoplasma. 2017;64(3):437-443. doi: 10.4149/neo_2017_315. PMID: 28253723
8. Development of Novel Monoclonal Antibodies for Evaluation of Transmembrane Prostate Androgen-Induced Protein 1 (TMEPAI) Expression Patterns in Gastric Cancer. Karbyshev MS, Grigoryeva ES, Volkomorov VV, Kremmer E, Huber A, Mitrofanova IV, KaigorodovaEV, Zavyalova MV, Kzhyshkowska JG, Cherdyntseva NV, Choynzonov EL. Pathol Oncol Res. 2017 Jun 5. doi: 10.1007/s12253-017-0247-x.
9. Types of Immune-Inflammatory Responses as a Reflection of Cell-Cell Interactions under Conditions of Tissue Regeneration and Tumor Growth. Tashireva LA, Perelmuter VM, Manskikh VN, Denisov EV, Savelieva OE, Kaygorodova EV, Zavyalova MV. Biochemistry (Mosc). 2017 May;82(5):542-555. doi: 10.1134/S0006297917050029. Review.
10. Kaigorodova EV, Zavyalova MV, Bychkov VA, Perelmuter VM, Choynzonov EL. Functional state of the Hsp27 chaperone as a molecular marker of an unfavorable course of larynx cancer. Cancer Biomark. 2016 Jun 24;17(2):145-53. doi: 10.3233/CBM-160625.
11. Comprehensive meta-analytical summary on human papillomavirus association with head and neck cancer. Bychkov VA, Nikitina EG, Ibragimova MK, Kaigorodova EV, Choinzonov EL, Litviakov NV. Exp Oncol. 2016 Jun;38(2):68-72. Review. PMID:27356572
12. Zavyalova M., Vtorushin S.V. , Telegina N. , Krakhmal N. , Savelieva O. , Tashireva L. , Bragina O. , Denisov E.V. , Kaigorodova E.V. , Slonimskaya E. , Choynzonov E.L. , Perelmuter V.M. Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes// Exp Oncol 2016 Vol.38,N 2, P:122–127 http://exp-oncology.com.ua/article/8568/clinicopathological-features-of-nonspecific-invasive-breast-...
13. Invasive and drug resistant expression profile of different morphological structures of breast tumors. Denisov EV, Gerashchenko TS, Zavyalova MV, Litviakov NV, Tsyganov MM, Kaigorodova EV, Slonimskaya EM, Kzhyshkowska J, Cherdyntseva NV, Perelmuter VM. Neoplasma. 2015;62(3):405-11. doi: 10.4149/neo_2015_041.
14. Kaigorodova EV, Zavyalova MV, Bogatyuk MV, Tarabanovskaya NA, Slonimskaya EM, Perelmuter VM. Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer. Cancer Biomark. 2015;15(2):143-50. doi: 10.3233/CBM-140446.
15. Kaigorodova EV, Bogatyuk MV. Heat shock proteins as prognostic markers of cancer. Curr Cancer Drug Targets. 2014;14(8):713-26. Review. PMID: 25258164 DOI : 10.2174/1568009614666140926122846