Marusin Andrey Viktorovich
PhD, Researcher in the laboratory of evolutionary genetics of Research Institute of Medical Genetics, Tomsk National Research Medical Center.
Brief biography
Marusin Andrey Viktorovich, born in 1971, Russian, higher education: in 1994 he graduated with honors from Tomsk State University with a degree in biology. He has been working in the team of the Research Institute of Medical Genetics since 1992, first as a laboratory assistant, and since October 2000, he was a junior researcher in the laboratory of evolutionary genetics. He graduated from full-time postgraduate study at the Research Institute of MG (1997 - 2000). In 2001 he defended his thesis for the degree of candidate of biological sciences on the topic: "Variability and heritability of antioxidant activity of blood plasma in Siberian populations." From 2002 to the present, he has been working as a researcher in the laboratory of evolutionary genetics.
Research Interests
The main works of Marusin A.V. lie in the study of the genetics of quantitative traits and the medical genetics of multifactorial diseases. In the field of scientific interests are studies of genetic, adaptive and evolutionary processes in human populations. Interdisciplinary research in biological, social anthropology and ethnology, the study of ancient DNA, transcultural addictology, genetics of behavior, genetics of neuropsychiatric and neuropsychiatric diseases. Recently, the bioinformation analysis of the results of full-exomic sequencing using new generation methods (NGS) has been of greatest interest.
Marusin A.V. He is the author and co-author of more than 100 scientific publications. The manager (M) and the performer (P) of the following projects:
00-04-48506-a "The origin and evolution of the Y-chromosome lines in the peoples of the Altai language family" (RFBR, P);
02-04-49166-a "Characterization of the gene pool of populations of Northern Eurasia using polymorphic Alu insertions" (RFBR, P);
03-04-49021-a "Phylogeography of the Y-chromosome lines in Siberia and Central Asia" (RFBR, P);
05-04-98007-r_ob_a "The study of the molecular genetic foundations of exposure and the development of a test system for diagnosing alcoholism in the Siberian region" (RFBR, M);
06-04-08326-ofi "Development of methods for the genomic diagnosis of susceptibility to diseases of the cardiovascular continuum" (RFBR, P);
06-04-48274-a "Evolution and phylogeography of human Y-chromosome lines in the population of Northern Eurasia" (RFBR, P);
04-04-01629-a "Linkage disequilibrium architecture, haplotype evolution, and genetic diversity of parts of the human genome of different localization in Eurasian populations" (RFBR, P);
09-04-92665-IND_a "The origin and settlement of Indo-Europeans: phylogeography of the Y-chromosome haplogroup R1a1" (RFBR, P);
09-04-99028-r_ofi "Evaluation of the effectiveness of predictive genetic tests and the development of an expert system for predicting the development of complicated pregnancy in populations of different ethnic origin" (RFBR, P);
09-04-99083-r_ofi "Genetic factors in the etiology and pathogenesis of alcoholism in the population of Western Siberia" (RFBR, M);
11-04-98069-p_sibir_a "The structure of linkage disequilibrium and the evolution of haplotypes of genes of the serotonergic system in populations of the West Siberian region: the relationship with psychodiagnostic traits in the Russian population of the Tomsk Region" (RFBR, M);
12-04-00595-a "Ethnic genomics of neuropsychiatric diseases in populations of Russia" (RFBR, P);
14-04-01467-a "Identification of ethno-population characteristics of susceptibility to preeclampsia in populations of Russia using the approaches of genomics and transcriptomics" (RFBR, P);
ADAMS — Genomic variations underlying common behavior diseases and cognition trait in human populations. Seventh Framework Program of the European Union FP7-HEALTH-2009. 2009-2012. Grant # 242257 (P);
16-15-00020 "The genetic basis of the variability of cognitive functions in the elderly and in patients with Alzheimer's disease" (RSF, P).
Marusin A.V. scientific achievements awarded the diploma of the Laureate of the Prize of the Tomsk Region in the field of education, science, healthcare and culture in the nomination "Prizes to scientific and scientific-pedagogical collectives" (2017) and a Letter of Thanks from the Duma of the Tomsk city (2017).
Chapters in monographs:
1. Marusin A.V., Bobrova A.I., Rykun M.P., Ozheredov Yu.I., Stepanov V.A. Analysis of the polymorphism of the Alu mobile genetic element in the locus of the angiotensin-converting enzyme gene in a sample of the Pre-Selkup population (according to medieval necropolises of the Narym Ob region) // Materials and studies of ancient, medieval and modern history of Central and Central Asia: Proceedings of the Museum of Archeology and Ethnography of Siberia, Tomsk State University . - Tomsk: Tomsk State University, 2010. – V.. III, no. 1. - P. 128-134.
2. Stepanov V.A., Kharkov V.N., Trifonova E.A., Marusin A.V. Methods of statistical analysis in population and evolutionary human genetics (Heredity and health): teaching aid / Ed. V.P. Puzyrev. - Tomsk: Publishing house "Printing Manufactory", 2014. - 100 p. (Chapter 12. Cartographic analysis of genetic data and phylogeography, P. 65-73).
Publications:
1. Kutmin A.I., Marusin A.V. Antioxidant activity of blood plasma in individuals with different doses of rare-ionizing chronic radiation. Bulletin of Experimental Biology and Medicine. - 1999. - V. 127 (Suppl. 1). - P. 34-37.
2. Marusin A.V., Puzyrev V.P., Bragina E.Yu. Lack of associations of polymorphic variants of glutathione peroxidase and transferrin genes with antioxidant activity of blood plasma // Bull. SB RAMS. - 2000. - No. 3-4 (97-98). - P. 99-104.
3. Marusin A.V., Puzyrev V.P., Bragina E.Yu. Population-genetic analysis of variability of antioxidant activity in human blood plasma // Sib. med. magazine. - 2001. - V. 16, No. 1. - P. 41-46.
4. Marusin A.V., Salyukov V.B., Bragina E.Yu. Antioxidant activity of blood plasma in groups of individuals with neoplasms // Bull. experiment. biol. and med. - 2002. - V. 133, No. 5. - P. 556-558.
5. Marusin A.V., Puzyrev V.P., Salyukov V.B., Bragina E.Yu. Genetic variability of antioxidant activity of blood plasma in a sample of the population of Seversk, Tomsk Region // Bulletin of Siberian medicine. - 2002. - No. 3. - P. 24-29.
6. Marusin A.V., Puzyrev V.P., Salyukov V.B., Bragina E.Yu. The relationship of polymorphic variants of transferrin genes and angiotensin-converting enzyme with antioxidant activity of blood plasma // Russian Journal of Genetics. - 2003. - V. 39, No. 6. - P. 840-846.
7. Marusin A.V., Stepanov V.A., Spiridonova M.G., Puzyrev V.P. Gene polymorphism of alcohol dehydrogenases ADH1B and ADH7 in Russian populations of the Siberian region // Molecular Biology. - 2004. - V. 38, No. 4. - P. 625-631.
8. Marusin A.V., Popova N.A., Salyukov V.B., Stepanov V.A., Nazarenko S.A. Antioxidant activity of blood plasma and the level of chromosomal abnormalities in humans with prolonged γ-irradiation in small doses // Bull. an experiment. biol. and med. - 2005. - V. 139, No. 6. - P. 672-674.
9. Marusin A.V., Stepanov V.A., Spiridonova M.G., Bohan N.A., Mandel A.I., Kharkov V.N., Pels Ya.R., Puzyrev V.P. Gene polymorphism of ethanol-metabolizing enzymes ADH1B, ADH7, and CYP2E1, a risk of developing alcoholism, comorbid with tuberculosis, in the Russian population of the West Siberian region // Medical Genetics. - 2006. - V. 5. No. 7. - P. 51-56.
10. Marusin A.V., Stepanov V.A., Spiridonova M.G., Kharkov V.A., Pels Ya.R., Puzyrev V.P. Analysis of associations of genetic polymorphism of enzymes metabolizing ethanol ADH1B, ADH7 and CYP2E1 with the risk of coronary atherosclerosis // Russian Journal of Genetics. - 2007. - V. 43, No. 3.- P. 409-416.
11. Pels Ya.R., Marusin A.V., Spiridonova M.G., Stepanov V.A. Polymorphism of the MDR1 gene in populations of Siberia and Central Asia // Molecular Biology. - 2007. - V. 41, No. 6. - P. 982-988.
12. Marusin A.V., Spiridonova M.G., Abushaeva M.O., Bohan N.A., Stepanov V.A. Association of 1342 A / G polymorphism in exon 9 and tandem repeat lengths (VNTR) in the 3'-non-coding region (3'-UTR) of the DAT1 dopamine transporter gene (SLC6A3) with a risk of alcohol dependence formation in the West Siberian Russian population // Medical Genetics . - 2008. - No. 6. - P. 31-35.
13. Borinskaya S., Kal'ina N., Marusin A., Faskhutdinova G., Morozova I., Kutuev I., Koshechkin V., Khusnutdinova E., Stepanov V., Puzyrev V., Yankovsky N., Rogaev E. Distribution of the alcohol dehydrogenase ADH1B*47 His allele in Eurasia // Am. J. Hum. Genet. - 2009. - V. 84, N 1. - P. 89-92; author reply 92-94.
14. Li H., Borinskaya S., Yoshimura K., Kal'ina N., Marusin A., Stepanov VA, Qin Z., Khaliq S., Lee MY, Yang Y., Mohyuddin A., Gurwitz D., Mehdi SQ , Rogaev E., Jin L., Yankovsky NK, Kidd JR, Kidd KK Refined geographic distribution of the oriental ALDH2 * 504Lys (nee 487Lys) variant // Ann. Hum. Genet. - 2009. - V. 73, N 3. - P. 335-345.
15. Marusin A.V., Maksimova N.R., Matveeva N.P., Spiridonova M.G., Stepanov V.A. The association of polymorphism of the dopamine transporter genes DAT1 (SLC6A3) and ethanol-metabolizing enzymes ADH1B and CYP2E1 with the risk of alcohol dependence in the Yakut population // Yakut Medical Journal. - 2009. - No. 2. - P. 148-150.
16. Kurtanov H.A., Maksimova N.R., Marusin A.V., Stepanov V.A. Polymorphism of the OPMD locus in populations of Yakutia // Yakut Medical Journal. - 2009. - No. 2. - P. 54 - 58.
17. Spiridonova M.G., Trapp N.V., Stepanova S.K., Marusin A.V., Sukhomyasova A.L., Stepanov V.A. Haplotype diversity in the DMPK gene in a sample of patients with myotonic dystrophy from the Republic of Sakha (Yakutia) and in populations of Northern Eurasia // Yakut Medical Journal. - 2009. - No. 2. - P. 156-158.
18. Sepanova S.K., Spiridonova M.G., Marusin A.V., Sukhomyasova A.L., Stepanov V.A. Haplotype diversity in the DMPK gene in a sample of patients with myotonic dystrophy from the Republic of Sakha (Yakutia) and in populations of Northern Eurasia // Yakut Medical Journal. - 2011. - No. 4. - P. 45-52.
19. Stepanov V.A., Balanovsky O.P., Melnikov A.V., Lash-Zavada A.Yu., Kharkov V.N., Tyazhelova T.V., Akhmetova V.L., Zhukova O.V., Schneider Yu.V., Shilnikova N.N., Borinskaya S.A., Marusin A.V., Spiridonova M.G., Simonova K.V., Khitrinskaya I.Yu., Radjabov M.O., Romanov A .G., Shtygasheva O.V., Koshel S.M., Balanovskaya E.V., Rybakova A.V., Khusnutdinova E.K., Puzyrev V.P., Yankovsky N.K. Characterization of populations of the Russian Federation according to the panel of fifteen loci used for DNA identification and in forensic examination // Acta Naturae. - 2011. - T. 3, No. 2. - P. 56-67.
20. Bokhan N.A., Matveeva N.P., Khoyutanova N.V., Tomsky M.I., Maksimova N.R., Stepanov V.A., Marusin A.V., Olesova L.D., Krivoshapkina Z N. Clinical and pathobiological patterns of the formation of alcoholism in the indigenous population of Sakha (Yakutia): results and prospects of interdisciplinary research // Siberian Bulletin of Psychiatry and Narcology. - 2012. - No. 3 (72) - P. 21-28.
21. Nizamutdinov I.I., Andreeva T.V., Stepanov V.A., Marusin A.V., Rogaev E.I., Zasedatelev A.S., Nasedkina T.V. A biochip for identifying genetic risk markers for the development of a sporadic form of Alzheimer's disease in the Slavic population of Russia // Molecular Biology. - 2013. - V. 47, No. 6. - P. 949-958.
22. Stepanov V.A., Bocharova A.V., Marusin A.V., Zhukova N.G., Alifirova V.M., Zhukova I.A. Replicative analysis of associations of genetic markers of cognitive traits with Alzheimer's disease in the Russian population // Molecular Biology. - 2014. - V. 48, No. 6. - P. 952-962.
23. Swarovskaya M.G., Marusin A.V., Tacheeva T.I., Khitrinskaya I.Yu., Gafarov N.I., Stepanov V.A. Analysis of eight polymorphic Alu-elements in the Teleut population // Russian Journal of Genetics. - 2015. - V. 51, No. 8. - P. 963-966.
24. Swarovskaya M.G., Stepanova S.K., Marusin A.V., Sukhomyasova A.L., Maksimova N.R., Stepanov V.A. Genetic variability and structure of SNP haplotypes in the DMPK gene in Yakuts and other ethnic groups of northern Eurasia in connection with myotonic dystrophy // Russian Journal of Genetics. - 2015. - V. 51, No. 6. - P. 724-732.
25. Swarovskaya M.G., Stepanova S.K., Marusin A.V., Sukhomyasova A.L., Maksimova N.R., Stepanov V.A. Analysis of CTG repeats in the DMPK gene in populations of Yakutia, Siberia, and Central Asia // Medical Genetics. - 2015. - V. 14, No. 7 (157). - P.17-21.
26. Stepanov V.A., Bocharova A.V., Saduakasova K.Z., Marusin A.V., Koneva L.A., Vagaitseva K.V., Svyatova G.S. A replicative study of susceptibility to schizophrenia with an early onset in Kazakhs // Russian Journal of Genetics. - 2015.- V. 51, No 2.- P. 227–235.
27. Marusin A.V., Kurtanov H.A., Maksimova N.R., Swarovskaya M.G., Stepanov V.A. Haplotype analysis of the oculopharyngeal myodystrophy locus (OFMD) in Yakutia // Russian Journal of Genetics. - 2016. - V. 52, No. 3. - P. 376–384.
28. Marusin A.V., Kornetov A.N., Swarovskaya M.G., Vagaitseva K.V., Pavlenyuk E.S., Stepanov V.A. Association of genes for susceptibility to alcoholism, schizophrenia and Alzheimer's disease with psychodiagnostic traits in the Russian population // Bulletin of Siberian medicine. - 2016. - V. 15, No. 5. - P. 83-96.
29. Stepanov V., Marusin A., Vagaitseva K., Bocharova A., Makeeva O. Genetic variants in CSMD1 gene are associated with cognitive performance in normal elderly population // Genetics Research International. - 2017 . - V. 2017 . - P. 6293826.
30. Triska P., Chekanov N., Stepanov V., Khusnutdinova EK, Kumar GPA, Akhmetova V., Babalyan K., Boulygina E., Kharkov V., Gubina M., Khidiyatova I., Khitrinskaya I., Khrameeva EE, Khusainova R., Konovalova N., Litvinov S., Marusin A., Mazur AM, Puzyrev V., Ivanoshchuk D. et al. Between lake Baikal and the Baltic sea: genomic history of the gateway to Europe // BMC Genetics. - 2017. - V. 1, No. Suppl. 1 .- P. 110.
31. Bocharova A.V., Stepanov V.A., Marusin A.V., Kharkov V.N., Vagaitseva K.V., Fedorenko O.Yu., Bohan N.A., Semke A.V., Ivanova S .AND. Analysis of associations of genetic markers of schizophrenia and its cognitive endophenotypes // Russian Journal of Genetics. - 2017.- V. 53, No. 1. - P. 100-108.
32. Bocharova A.V., Vagaitseva K.V., Makeeva O.A., Marusin A.V., Stepanov V.A. Frequencies of alleles, genotypes and haplotypes of two polymorphisms in the Clusterin gene in the Russian elderly population categorized by cognitive performance // Data in Brief. - 2018. - V. 16. - P. 775-779.
33. Stepanov V., Vagaitseva KV, Bocharova AV, Marusin AV, Minaycheva L., Makeeva O., Markova V. Analysis of association of genetic markers in the LUZP2 and FBXO40 genes with the normal variability in cognitive performance in the elderly // International Journal of Alzheimer's Disease. - 2018 . - V. 2018 . - P. 2686045.
34. Marusin A.V., Makeeva O.A., Vagaitseva K.V., Bocharova A.V., Swarovskaya M.G., Salakhov R.R., Stepanov V.A. The Association of the Apolipoprotein E Gene with the Cognitive Variability of the Elderly // Medical Genetics. - 2018. - V. 17, No. 1. - P. 20-26.
35. Bocharova A.V., Marusin A.V., Makeeva O.A., Zhukova I.A., Zhukova N.G., Alifirova V.M., Stepanov V.A. Genetic variants associated with impaired human cognitive functions in Alzheimer's disease // Medical Genetics. - 2018. -V. 17, No. 1. - P. 14-19.
36. Stepanov V.A., Bocharova A.V., Vagaitseva K.V., Marusin A.V., Markova V.V., Minaicheva L.I., Zhukova I.A., Zhukova N.G., Alifirova V .M., Makeeva O.A. A rare variant in the gene for sortin-like receptor 1: a relationship with indicators of cognitive function in the elderly // Journal of Neurology and Psychiatry S.S. Korsakova. - 2018.- V. 118, No. 5. - P. 92-95.
37. Vagaitseva K.V., Bocharova A.V., Marusin A.V., Kolesnikova E.A., Makeeva O.A., Stepanov V.A. Development of a method for multiplex genotyping of polymorphic gene markers associated with cognitive abilities // Russian Journal of Genetics. - 2018.- V. 54, No. 6. - P. 719-726.
38. Minaicheva L.I., Bragina E.Yu., Zhalsanova I.Zh., Chesnokova N.A., Marusin A.V. Association of genetic markers of celiac disease with reproductive disorders // Almanac of Clinical Medicine. - 2019 . - V. 47, No. 1. - P. 72-82.
39. Stepanov V.A., Kharkov V.N., Vagaitseva K.V., Khitrinskaya I.Yu., Bocharova A.V., Kolesnikov N.A., Zarubin A.A., Popovich A.A., Marusin A .V., Spiridonova M.G., Triska P., Tatarinova T.V. Directional selection signals in populations of the peoples of Siberia and the European part of Russia // Russian Journal of Genetics. - 2019 . - V. 55, No. 10. - P. 1198-1207.