Personalities

Maria A. Nazarenko

MARIA NAZARENKO, Senior Research Officer/Head of the Laboratory, Laboratory of Population Genetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science

Contact details

e-mail: maria.nazarenko@medgenetics.ru
Phone: +7(3822) 51-72-72
Fax: +7(3822) 51-37-44

Brief Biography

8/1996 - 5/2002 M.D. {Paediatrics}, Siberian State Medical University, Tomsk, Russia.
8/2002 - 5/2004 Residency and Internship, Research Institute of Medical Genetics Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia. Young Research Officer, Laboratory of Population Genetics, Research Institute of Medical Genetics Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia.
2/2007 Ph.D. {Genetics}, Research Institute of Medical Genetics Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia. Ph. D. thesis: “Analysis of polymorphisms of genes of folate metabolism, nitric oxide synthase and cytokines in the early human development”, speciality Genetics.
2/2007-9/2015 Research Officer, Laboratory of Population Genetics, Research Institute of Medical Genetics, Siberian Branch of Russian Academy of Medical Science, Tomsk, Russia.
9/2009-present Assistant professor, Medical genetics, Siberian State Medical University, Tomsk, Russia.
9/2015-present Senior Research Officer/Head of the Laboratory, Laboratory of Population Genetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russia.
1/2018 D.Sc.{Genetics},Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Science, M.D. thesis: “Copy number variations and DNA methylation changes of vascular cells and leukocytes of patients with coronary and carotid atherosclerosis”, speciality Genetics.

Achievements, awards, and grants

• Local government of Tomsk region awards for scientific advances in Medical Genetics, Tomsk, 2011, 2015, 2016, 2017.
• Award for the best Russian innovative medical technology, Russian scientific conference of young scientists and physicians “Innovative medical technologies of the 21st century”, Moscow, 2012.
• Diploma of III degree for the best oral report at the VI Congress of the Vavilov Society of Geneticists and Breeders, Rostov-on-Don, 2014.
• Diploma (№ 107), winner of the Little Prize in 2013 for “International Academic Publishing Company” Nauka / Interperiodica for best publication in its journals (November 11, 2014, protocol № 2).
• Certificate of Merit from the Tomsk Oblast Administration for the great contribution to the development of scientific research, training of highly qualified specialists, and the Day of Russian Science, 2015.
• Words of Appreciation the Council of Rectors of Tomsk region for contribution to stuff training, development of the research and the celebration of the Russian Science Day. Council of Rectors of Universities of the Tomsk region, Professor GV Meyer, 2016.
• Diploma of the Presidium of the Siberian Branch of the RAS for work, contribution to the medical academic science in Siberia, scientific research and in connection with the 35th anniversary of the Tomsk Scientific Research Institute of Medical Genetics, 2017.

Main Publications

1. Ponomarenko M, Rasskazov D, Chadaeva I, Sharypova E, Drachkova I, Oshchepkov D, Ponomarenko P, Savinkova L, Oshchepkova E, Nazarenko M, Kolchanov N. Candidate

SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding

Protein for Human Gene Promoters show stabilizing Natural Selection as a Sum of

Neutral Drift Accelerating Atherogenesis and Directional Natural Selection

Slowing It. Int J Mol Sci. 2020 Feb 5;21(3). pii: E1045. doi: 10.3390/ijms21031045.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037642/

2.Nazarenko M.S., Markov A.V., Sleptsov A.A., Koroleva I.A., Sharysh D.V., Zarubin A.A.,

Valiahmetov N.R., Goncharova I.A., Muslimova E.F., Kuznecov M.S., Kozlov B.N., Afanasiev S.A., Puzyrev V.P. [Comparative analysis of gene expression in vascular cells of patients with advanced atherosclerosis]. Biomed Khim. 2018 Sep;64(5):416-422.

doi: 10.18097/PBMC20186405416. Russian.

https://link.springer.com/article/10.1134/S1990750819010104

3. Koroleva I.A., Nazarenko M.S., Kucher A.N. Role of microRNA in Development of Instability of Atherosclerotic Plaques. Biochemistry (Mosc). 2017 Nov;82(11):1380-1390. doi: 10.1134/S0006297917110165.

https://link.springer.com/article/10.1134%2FS0006297917110165

4. Nazarenko M.S., Sleptcov A.A., Lebedev I.N., Skryabin N.A., Markov A.V., Golubenko M.V., Koroleva I.A., Kazancev A.N., Barbarash O.L., Puzyrev V.P. Genomic structural variations for cardiovascular and metabolic comorbidity. Sci Rep. 2017 Jan 25;7:41268. doi:10.1038/srep41268.

https://www.nature.com/articles/srep41268

5. Kucher A.N., Nazarenko M.S., Markov A.V., Koroleva I.A., Barbarash O.L. Variability of Methylation Profiles of CpG Sites in microRNA Genes in Leukocytes and Vascular Tissues of Patients with Atherosclerosis. Biochemistry (Mosc). 2017 Jun;82(6):698-706. DOI: 10.1134/S0006297917060062.

http://protein.bio.msu.ru/biokhimiya/contents/v82/full/82060923.html

6. Golubenko M.V., Nazarenko M.S., Frolov A.V., Sleptsov A.A., Markov A.V., Glushkova M.E., Barbarash O.L., Puzyrev V.P. [Analysis of Heteroplasmy in the Major Noncoding Region of Mitochondrial DNA in the Blood and Atherosclerotic Plaques of Carotid Arteries]. Genetika. 2016 Apr;52(4):497-502. Russian.

https://link.springer.com/article/10.1134/S1022795416040049

7. Nazarenko M.S., Markov A.V., Lebedev I.N., Freidin M.B., Sleptcov A.A., Koroleva I.A., Frolov A.V., Popov V.A., Barbarash O.L., Puzyrev V.P. A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease. PLoS One. 2015 Apr 9;10(4):e0122601. doi:10.1371/journal.pone.0122601.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391864/

8. Sleptsov A.A., Nazarenko M.S., Lebedev I.N., Skryabin N.A., Frolov A.V., Popov V.A., Barbarash O.L., Barbarash L.S., Puzyrev V.P. [Somatic genome variations in vascular tissues and peripheral blood leukocytes in patients with atherosclerosis]. Genetika. 2014. Aug;50(8):986-95. Russian.

https://link.springer.com/article/10.1134/S1022795414080080

9. Nazarenko M.S., Markov A.V., Lebedev I.N., Sleptsov A.A., Frolov A.V., Barbash O.L., Puzyrev V.P. [DNA methylation profiling of the vascular tissues in the setting of  atherosclerosis]. Mol Biol (Mosk). 2013 May-Jun;47(3):398-404. Russian.

http://link.springer.com/article/10.1134%2FS0026893313030084

10. Nazarenko M.S., Markov A.V., Lebedev I.N., Slepsov A.A., Koroleva Y.A., Frolov A.V., Barbarash O.L., Barbarash L.S., Puzirev V.P. [Methylation profile of INK4B-ARF-INK4A locus in atherosclerosis]. Genetika. 2013 Jun;49(6):783-7. Russian.

http://link.springer.com/article/10.1134%2FS1022795413060070

11. Babyshkina N., Malinovskaya E., Nazarenko M., Koval M., Gervas P., Potapova O., Slonimskaya E., Cherdyntseva N. The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients. Gene. 2013 Apr 15;518(2):397-404.

http://www.sciencedirect.com/science/article/pii/S037811191201654X

12. Nazarenko M.S., Puzyrev V.P., Lebedev I.N., Frolov A.V., Barbarash O.L., Barbarash L.S. [Methylation profiling of human atherosclerotic plaques]. Mol Biol (Mosk). 2011 Jul-Aug;45(4):610-6. Russian.

http://link.springer.com/article/10.1134%2FS0026893311030125

13. Perel’muter V.M., Zav’ialova M.V., Vtorushin S.V., Slonimskaia E.M., Kritskaia N.G., Garbukov E.Iu., Litviakov N.V., Stakheeva M.N., Babyshkina N.N., Malinovskaia E.A., Denisov E.V., Grigor’eva E.S., Nazarenko M.S., Sennikov S.V., Goreva E.P., Kozlov V.A., Voevoda M.I., Maksimov V.N., Beliavskaia V.A., Cherdyntseva N.V. [Genetic and clinical and pathological characteristics of breast cancer in premenopausal and postmenopausal women]. Adv Gerontol. 2008;21(4):643-53. Russian.

14. Nazarenko M.S., Puzyrev V.P., Lebedev I.N. [Frequencies of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene at the early stage of human individual development]. Genetika. 2006 May;42(5):711-7. Russian.

http://link.springer.com/article/10.1134%2FS1022795406050164