Lyudmila P. Nazarenko
Contact information
e-mail: ludmila.nazarenko@medgenetics.ru
fax: +7(3822)53-56-83
Brief biography
Lyudmila P. Nazarenko graduated from the Pediatric Faculty of the Kyrgyz State Medical Institute in 1971. From 1973 to 1974, she was a resident physician at the neurological department of the Kyrgyz Research Institute for the Protection of Motherhood and Childhood. From 1974 to 1977, she was a PhD student of the Institute of Medical Genetics, USSR Academy of Medical Sciences (Moscow). In 1978, she obtained her PhD degree in Genetics and began to work as a senior researcher at the Kyrgyz Institute of Obstetrics and Pediatrics. Since 1982, she has been an employee of the Department of Medical Genetics at the Siberian Branch of Cancer Research Center, Academy of Medical Sciences of the USSR, which was reorganized in 1987 into the Research Institute of Medical Genetics of the Siberian Branch of the Russian Academy of Medical Sciences. In 1998, Lyudmila Nazarenko defended doctoral thesis for an academic degree of Doctor of Sciences. In 2002, she was awarded the rank of Professor in Genetics. She held the following positions working at the institute: Head of the laboratory of hereditary pathology, Head of the outpatient department, and Head of the genetics clinic. From 2007 to the present Lyudmila P. Nazarenko is the Deputy Director for Scientific and Medical Work of the Research Institute of Medical Genetics of Tomsk NRMC. She has been engaged in teaching since 1999, with the position of associate professor and since 2005 - Professor of the Department of Medical Genetics in Siberian State Medical University.Research Interests
Molecular epidemiology of hereditary diseases and congenital malformations in Siberian populations (Slavic and aboriginal Tuvans, Khakas, Altaians, Yakuts, Buryats); organization and development of regional medical genetic counseling.
Research Interests
New technologies for the diagnosis, treatment and prevention of rare hereditary diseases in the Siberian region; development and organization of regional medical genetic counseling.
Achievements, awards, and grants
The result of the scientific work of Lyudmila P. Nazarenko is the introduction of the technology of a comprehensive study of human populations, monitoring the burden of hereditary pathology and improving medical genetic services to the population of Siberia in the healthcare practice. The developed technology has been translated into the healthcare practice and the medical genetic services of six regions of Siberia (Tomsk region, Tyva Republic, Republic of Khakassia, Altai Republic, Republic of Buryatia, Republic of Sakha (Yakutia)). The load of hereditary diseases and its variations were defined in these regions, frequent and rare genetic diseases were described, and the factors for the differentiation of populations by level and spectrum of hereditary pathology were revealed. Specific hereditary diseases were identified in theses six regions of Siberia. Prevention programs for these diseases were developed and translated into practice.
In 1994 Lyudmila P. Nazarenko and colleagues had established the Genetic Clinic within the Research Institute of Medical Genetics. At present, the Genetic Clinic is the unique center in Siberia that provides medical genetic services for patients with hereditary and congenital diseases. Lyudmila P. Nazarenko also provides the counseling of patients with suspected genetic disorders in many regions of Siberia. She is always shares her experience in medical genetics with colleagues.
Lyudmila P. Nazarenko created an excellent atlas of clinical manifestations of hereditary diseases in photographs, video recordings, which is used for teaching students and doctors at the Department of Medical Genetics of the Siberian State Medical University. She also created a lecture course for doctors, which has been successfully implemented in many cities of Siberia. Lyudmila P. Nazarenko organized annual conferences and schools for doctors about hot topics in human medical genetics.
Lyudmila P. Nazarenko has been awarded with the government and scientific community awards such as the Order of Friendship, diploma of the government of the Republic of Tuva, Republic of Sakha (Yakutia) and the Republic of Buryatia, S.N. Davidenkov’s Medal and the Diploma of the Russian Society of Medical Genetics. She is Honored Doctor of the Russian Federation. She is a Laureate of Tomsk region award in the field of Science and Healthcare.
Lyudmila P. Nazarenko is a member of the editorial board of the journal of Medical Genetics. She is a member of the Academic Council of the Tomsk National Research Medical Center of the Russian Academy of Sciences, a member of the Academic Council of the Research Institute of Medical Genetics. Lyudmila Nazarenko is a member of the Russian Society of Medical Genetics, European Society of Human Genetics. She is an expert for medical genetic services of the Ministry of Health of the Russian Federation in the Siberian Federal District.
Lyudmila P. Nazarenko is an author of more than 370 scientific publications, including 6 books.
Main publications
1. Nazarenko LP, Puzyrev VP. Oxford monographs on medical genetics “Genomics and health in the developing world” Chapter 112. “Hereditary diseases among the Yakuts” / Ed. By D. Kumar. Oxford University Press, Inc. Oxford, New York. 2012. Р. 1323-1354.2. Nazarenko SA, Ostroverkhova NV, Vasiljeva EO, Nazarenko LP, Puzyrev VP, Malet P, Nemtseva TA. Keratosis pilaris and ulerythema ophryogenes associated with an 18p deletion caused by a Y/18 translocation. Am J Med Genet. 1999 Jul 16;85(2):179-82. PubMed PMID: 10406673.
3. Liakou AI, Esteves de Carvalho AV, Nazarenko LP. Trias of keratosis pilaris, ulerythema ophryogenes and 18p monosomy: Zouboulis syndrome. J Dermatol. 2014 May;41(5):371-6. doi: 10.1111/1346-8138.12442. Review. PubMed PMID: 24801913.
4. Nazarenko SA, Popova NA, Nazarenko LP, Puzyrev VP. Nuclear and chemical production and genetic health. Russian. Tomsk: Print Manufactory, 2004. 272 pp.
5. Puzyrev VP, Nazarenko LP. Genetic and epidemiological study of hereditary diseases in Western Siberia. Russian.Tomsk: STT, 2000. 192 pp.
6. Puzyrev VP, Erdynieva LS, Kucher AN, Nazarenko LP. Genetic and epidemiological study of the Tuva population. Russian. Tomsk: STT, 1999. 256 pp.
7. Genetic studies of the population of Yakutia. The team of authors including: Verbitskaya LI, Grigoriev AN, Pavlova TY, Puzyrev VP, Stepanov VA, Nazarenko LP, Kucher AN, Kharkov VN, Koneva LA, Konev AV, Trifonova EA, Maksimova NR, Suhomyasova AL, Nogovitsyna AN, et al. Russian.Tomsk ISBN 978-5-91441-070-1, 2014. 336 pp.
8. Khabarova AA, Pristyazhnyuk IE, Nikitina TV, Gayner TA, Torkhova NB, Skryabin NA, Kashevarova AA, Babushkina NP, Markova ZG, Minzhenkova ME, Nazarenko LP, Shilova NV, Shorina AR, Lebedev IN, Serov OL. Induced pluripotent stem cell line, ICAGi001-A, derived from human skin fibroblasts of a patient with 2p25.3 deletion and 2p25.3-p23.3 inverted duplication. Stem Cell Res. 2019 Jan;34:101377. doi:10.1016/j.scr.2018.101377. Epub 2018 Dec 18. PubMed PMID: 30616144.
9. Kashevarova AA, Nazarenko LP, Skryabin NA, Nikitina TV, Vasilyev SA, Tolmacheva EN, Lopatkina ME, Salyukova OA, Chechetkina NN, Vorotelyak EA, Kalabusheva EP, Fishman VS, Kzhyshkowska J, Graziano C, Magini P, Romeo G, Lebedev IN. A mosaic intragenic microduplication of LAMA1 and a constitutional 18p11.32 microduplication in a patient with keratosis pilaris and intellectual disability. Am J Med Genet A. 2018 Nov;176(11):2395-2403. doi:10.1002/ajmg.a.40478. Epub 2018 Sep 23. PubMed PMID: 30244536.
10. Gridina MM, Matveeva NM, Fishman VS, Menzorov AG, Kizilova HA, Beregovoy NA, Kovrigin II, Pristyazhnyuk IE, Oscorbin IP, Filipenko ML, Kashevarova AA, Skryabin NA, Nikitina TV, Sazhenova EA, Nazarenko LP, Lebedev IN, Serov OL. Allele-Specific Biased Expression of the CNTN6 Gene in iPS Cell-Derived Neurons from a Patient with Intellectual Disability and 3p26.3 Microduplication Involving the CNTN6 Gene. Mol Neurobiol. 2018 Aug;55(8):6533-6546. doi:10.1007/s12035-017-0851-5. Epub 2018 Jan 11. PubMed PMID: 29327201.
11. Kashevarova AA, Belyaeva EO, Nikonov AM, Plotnikova OV, Skryabin NA, Nikitina TV, Vasilyev SA, Yakovleva YS, Babushkina NP, Tolmacheva EN, Lopatkina ME, Savchenko RR, Nazarenko LP, Lebedev IN. Compound phenotype in a girl with r(22), concomitant microdeletion 22q13.32-q13.33 and mosaic monosomy 22. Mol Cytogenet. 2018 Apr 27;11:26. doi: 10.1186/s13039-018-0375-3. eCollection 2018. PubMed PMID: 29736186; PubMed Central PMCID: PMC5923029.
12. Lebedev IN, Nazarenko LP, Skryabin NA, Babushkina NP, Kashevarova AA. A de novo microtriplication at 4q21.21-q21.22 in a patient with a vascular malignant hemangioma, elongated sigmoid colon, developmental delay, and absence of speech. Am J Med Genet A. 2016 Aug;170(8):2089-96. doi: 10.1002/ajmg.a.37754. Epub 2016 Jun 10. PubMed PMID: 27288323.
13. Gridina M.M., Matveeva N.M., Fishman V.S., Menzorov A.G., Kizilova H.A., Beregovoy N.A., Kovrigin I.I., Pristyazhnyuk I.E., Oscorbin I.P., Filipenko M.L., Kashevarova A.A., Skryabin N.A., Nikitina T.V., Sazhenova E.A., Nazarenko L.P., Lebedev I.N., Serov O.L. Allele-specific biased expression of the CNTN6 Gene in iPS cell-derived 6 neurons from a patient with intellectual disability and 3p26.3 7 microduplication involving the CNTN6 gene // Molecular Neurobiology. 2018. V. 55. № 8. P. 6533-6546 (Q1)
14. Kashevarova A.A., Nazarenko L.P., Skryabin N.A., Nikitina T.V., Vasilyev S.A., Tolmacheva E.N., Lopatkina M.E., Salyukova O.A., Chechetkina N.N., Vorotelyak E.A., Kalabusheva E.P., Fishman V.S., Kzhyshkowska J., Graziano C., Magini P., Romeo G., Lebedev I.N. A mosaic intragenic microduplication of LAMA1 and a constitutional 18p11.32 microduplication in a patient with keratosis pilaris and intellectual disability // Am J Med Genet A. 2018 Sep 23 (Q3)
15. Kashevarova A.A., Belyaeva E.O., Nikonov A.M., Plotnikova O.V., Skryabin N.A., Nikitina T.V., Vasilyev S.A., Yakovleva Yu.S., Babushkina N.P., Tolmacheva E.N., Lopatkina M.E., Savchenko R.R., Nazarenko L.P., Lebedev I.N. Compound Phenotype in a Girl with r(22), Concomitant Microdeletion 22q13.32-q13.33 and Mosaic Monosomy 22 // Molecular Cytogenetics. 2018. Vol. 11, № 26 (Q4)
16. Gridina M.M., Nikitina T.V., Pristyazhnyuk I.E., Kashevarova A.A., Lopatkina M.E., Vasilyev S.A., Nazarenko L.P., Serov O.L. Generation of the induced pluripotent stem cell line, ICAGi002-A, from unaffected carrier megabase scaled duplication involving the CNTN6 gene // Stem Cell Research. 2019. Aug 28; 40: 101556.
17. Schnaider T.A., Pristyazhnyuk I.E., Menzorov A.G., Matveeva N.M., Khabarova A.A., Skryabin N.A., Kashevarova A.A., Lopatkina M.E., Nazarenko L.P., Lebedev I.N., Serov O.L. Generation of four iPSC lines from two siblings with a microdeletion at the CNTN6 gene and intellectual disability // Stem Cell Research. 2019
18. Khabarova A.A., Pristyazhnyuk I.E. , Nikitina T.V. , Gayner T.A. , Torkhova N.B., Skryabin N.A., Kashevarova A.A., Babushkina N.P., Markova Zh.G., Minzhenkova M.E., Nazarenko L.P., Shilova N.V., Shorina A.R., Lebedev I.N., Serov O.L. Induced pluripotent stem cell line, ICAGi001-A, derived from human skin fibroblasts of a patient with 2p25.3 deletion and 2p25.3-p23.3 inverted duplication // Stem Cell Research. Volume 34, January 2019, Номер статьи 101377. Open access 101377. P. 1-4
19. Kashevarova AA, Nazarenko LP, Schultz-Pedersen S, Skryabin NA, Salyukova OA, Chechetkina NN, Tolmacheva EN, Rudko AA, Magini P, Graziano C, Romeo G, Joss S, Tümer Z, Lebedev IN. Single gene microdeletions and microduplication of 3p26.3 in three unrelated families: CNTN6 as a new candidate gene for intellectual disability. Mol Cytogenet. 2014 Dec 31;7(1):97. doi: 10.1186/s13039-014-0097-0. eCollection 2014. PubMed PMID: 25606055; PubMed Central PMCID: PMC4299808.
20. Kashevarova AA, Nazarenko LP, Skryabin NA, Salyukova OA, Chechetkina NN, Tolmacheva EN, Sazhenova EA, Magini P, Graziano C, Romeo G, Kučinskas V, Lebedev IN. Array CGH analysis of a cohort of Russian patients with intellectual disability. Gene. 2014 Feb 15;536(1):145-50. doi: 10.1016/j.gene.2013.11.029. Epub 2013 Nov 27. PubMed PMID: 24291026.
21. Bushueva TV, Kuzenkova LM, Borovik TÉ, Nazarenko LP, Seitova GN, Filimonova MN, Pichkur NA, Samonenko NV, Shkurko TA, Akhmadeeva ÉN, Mardanova AK, Garifullina ÉR, Kovtun OP, Bazhenova IuL, Alimova IL, Kostiakova EA, Minaĭcheva LI, Saliukova OA, Sivokha VM, Rozenson OL. [Open, non-comparative phase III clinical study to evaluate the efficacy and safety of sapropterin in patients with phenylketonuria and hyperphenylalaninemia]. Vestn Ross Akad Med Nauk. 2014;(7-8):69-77. Russian. PubMed PMID: 25563006.
22. Kashevarova AA, Skryabin NA, Cheremnykh AD, Tolmacheva EN, Sazhenova EA, Salyukova OA, Chechetkina NN, Didenko LI, Sukhanova NN, Yakovleva YS, Torkhova NB, Nazarenko LP, Magini P, Graziano C, Romeo G, Lebedev IN. [Clinical and genetic analysis of idiopathic intellectual disability based on array comparative genomic hybridization]. Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(9):70-4. Russian. PubMed PMID: 24107884.
23. Popova NA, Nazarenko LP, Nazarenko SA. [Multiaberrant cell formation caused by exposure to internal densely-ionizing irradiation]. Genetika. 2004 Dec;40(12):1709-13. Russian. PubMed PMID: 15648155.
24. Saliukova OA, Nazarenko LP, Beresneva éA, Kotalevskaia IuIu, Fadiushina SV. [Prevalence of hereditary pathology in Altai Republic]. Genetika. 2004 Oct;40(10):1417-24. Russian. PubMed PMID: 15575511.
25. Krikunova NI, Minaĭcheva LI, Nazarenko LP, Tadinova VN, Nesterova VV, Fadiushina SV, Shapran NV. [Epidemiology of congenital malformations in Gorno-Altaisk, Altai Republic, Russia]. Genetika. 2004 Aug;40(8):1138-44. Russian. PubMed PMID: 15523853.
26. Nazarenko LP, Sazhenova EA, Nazarenko SA, Banshchikova ES. [A search for mutations in the DIA1 gene in case of hereditary methemoglobinemia type I in the Yiakut population]. Genetika. 2003 Jun;39(6):858-62. Russian. PubMed PMID: 12884529.
27. Ostroverkhova NV, Nazarenko SA, Rubtsov NB, Nazarenko LP, Bunina EN. Characterization of a small supernumerary ring marker derived from chromosome 2 by forward and reverse chromosome painting. Am J Med Genet. 1999 Nov 26;87(3):217-20. Review. PubMed PMID: 10564873.
28. Saliukova OA, Nazarenko LP, Saliukov VB. [Dynamics of the marital structure with respect to the nationality and birthplace of spouses in a modern urbanized Siberian population (as exemplified by Tomsk)]. Genetika. 1998 Sep;34(9):1293-7. Russian. PubMed PMID: 9879016.
29. Nazarenko SA, Ostroverkhova NV, Puzyrev VP, Nazarenko LP, Filimonova MN, Koriagina OIu. [Identification of marker chromosomes and translocations in man using a computerized diagnostic database and fluorescent in situ hybridization]. Genetika. 1998 Jan;34(1):114-21. Russian. PubMed PMID: 9532457.
30. Saliukova OA, Nazarenko LP, Puzyrev VP, Saliukov VB. [Genetic-demographic characteristics of farming regions and small cities of the Tomsk district]. Genetika. 1997 Jul;33(7):1005-11. Russian. PubMed PMID: 9378279.
31. Puzyrev VP, Lemza SV, Nazarenko LP, Panphilov VI. Influence of genetic and demographic factors on etiology and pathogenesis of chronic disease in north Siberian aborigines. Arctic Med Res. 1992 Jul;51(3):136-42. PubMed PMID: 1503580.
32. Kucher AN, Puzyrev VP, Nazarenko LP. [Genetic processes in rural populations of the Tomsk region (migration characteristics)]. Genetika. 1991 Jun;27(6):1084-94. Russian. PubMed PMID: 1837784.
33. Puzyrev VP, Lemza SV, Nazarenko LP, Panphilov VI. Influence of genetic and demographic factors on etiology and pathogenesis of chronic disease in north Siberian aborigines. Arctic Med Res. 1991;Suppl:420-2. PubMed PMID: 1365177.
34. Nazarenko SA, Nazarenko LP, Baranova VA. [Trisomy of the distal 15q region due to familial balanced translocation t(15;16)(q24;p13) and unusual mosaicism in the mother of the proband]. Tsitol Genet. 1987 Nov-Dec;21(6):434-7. Russian. PubMed PMID: 3445362.
35. Nazarenko SA, Nazarenko LP, Baranova VA. [Intra-individual polymorphism of human Y chromosome as a result of deletion in the heterochromatin region]. Genetika. 1987 May;23(5):918-21. Russian. PubMed PMID: 3623089.
36. Puzyrev VP, Abanina TA, Nazarenko LP, Lemza SV, Ostretsova OA. [A complex medico-genetic study of West Siberian populations. I. Formulation of a problem. Goals and objectives of the study. Population genetic characteristics of Northern Khanty]. Genetika. 1987 Feb;23(2):355-63. Russian. PubMed PMID: 3557120.
37. Nazarenko LP, Nazarenko SA, Puzyrev VP. [Case of medical-genetic consultation for Fanconi's anemia]. Pediatriia. 1986 Dec;(12):49-50. Russian. PubMed PMID: 3822707.
38. Puzyrev VP, Abanina TA, Nazarenko LP, Lemza SV, Ostretsova OA. [Medical genetic research on the Khanty population of the Ovgort rural district of the Yamal-Nenets Autonomous territory]. Genetika. 1985 Feb;21(2):332-7. Russian. PubMed PMID: 3857208.