Irina A. Goncharova
Irina A. Goncharova, PhD, Senior Researcher, Laboratory of Population Genetics, Research Institute of Medical GeneticsContact details
e-mail: ina.goncharova@medgenetics.ruPhone: 8 (3822) 51-72-72
Fax: 8 (3822) 51-37-44
Brief Biography
Irina Goncharova graduated from Tomsk State University in 1990. After graduation, she worked at the Laboratory of Cytogenetics of the Research Institute of Medical Genetics, and since 1996 to the present – at the Laboratory of Population Genetics. In 2002 she defended her thesis: “Variability of human genome regions under the influence of chronic gamma irradiation and individual radiosensitivity”.
Research Interests
Irina Goncharova is the author of more than 60 published papers, about 30 of her articles have been published in leading Russian and foreign journals such as Genetics, Molecular Biology, Medical Genetics, Molecular Medicine, International Journal of Low Radiation, and Meta Gene. Besides, she is the author of the monograph “The Role of Immunogenetics and Proteolysis in the Progression of Virus and Alcoholic Origin Liver Diseases”, patent for the invention No. 2376372 “Method of Genetic Diagnosis of Susceptibility to Cardiovascular Disease” and software No. 2014611785 “Calculation of the Therapeutic Dose of Warfarin (WarfarinSib) and medical technology Multiplex Genotyping of SNP-Markers of Hereditary Thrombophilia Using SNaPshot Method”. Her research interests include human susceptibility to common diseases, characteristics of the genome regulation depending on the presence of structural polymorphism under the influence of various pathological factors, pharmacogenetics, and network medicine.
Main Publications
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2. Goncharova I. A., Beloborodova E. V., Freidin M. B., Beloborodova E. I., Chernogoruk G. E., Puzyrev V. P. Genetic factors predisposing to a chronic course of virus hepatitis and liver fibrosis. Molecular Biology, 2008, Vol. 42, No. 2, pp. 238–241. 3. Goncharova I. A., Beloborodova E. V., Freidin M. B., Beloborodova E. I., Chernogoruk G. E., Puzyrev V. P. Association of immune system gene polymorphisms with quantitative traits pathogenetically important for chronic virus hepatitis. Molecular Biology, 2008, Vol. 42, No. 2, pp. 242–246.
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8. Golubenko M.V., Puzyrev V.P., Salakhov R.R., Makeeva O.A., Goncharova I.A., Kashtalap V.V., Barbarash O.L. Association of mitochondrial DNA polymorphism with myocardial infarction and prognostic signs for atherosclerosis. Molecular Biology. 2015. V. 49. № 6. P. 867-874. 9. Kucher A.N., Babushkina N.P., Kulish E.V., Makeeva O.A., Bragina E.Y., Goncharova I.A., Puzyrev V.P., Eremina E.R. Characteristic of the genetic variability of four polymorphic variants (rs2069705, rs17880053, rs11126176, and rs804271) in representative samples of indigenous and arrived populations of Siberia. Russian Journal of Genetics. 2015. V. 51. № 8. P. 812-817. 10. Goncharova I.A., Makeeva O.A., Golubenko M.V., Markov A.V., Tarasenko N.V., Sleptsov A.A., Puzyrev V.P. Genes for fibrogenesis in the determination of susceptibility to myocardial infarction. Molecular Biology. 2016. V. 50. № 1. P. 81-90. 12. Garaeva A.F., Babushkina N.P., Rudko A.A., Goncharova I.A., Bragina E.Y., Freidin M.B. Differential genetic background of primary and secondary tuberculosis in russians. Meta Gene. 2017. V. 11. P. 178-180. 15. Saik O.V., Demenkov P.S., Ivanisenko T.V., Bragina E.Y., Freidin M.B., Goncharova I.A., Dosenko V.E., Zolotareva O.I., Hofestaedt R., Lavrik I.N., Rogaev E.I., Ivanisenko VA. Novel candidate genes important for asthma and hypertension comorbidity revealed from associative gene networks. BMC Med Genomics. 2018 Feb 13;11(Suppl 1):15. doi: 10.1186/s12920-018-0331-4. 16. Bragina E.Y., Goncharova I.A., Garaeva A.F., Zhalsanova I.Z., Gomboeva D.E., Freidin M.B., Nemerov E.V., Babovskaya A.A., Karpov A.B., Semenova Y.V., Saik O.V., Ivanisenko V.A., Zolotareva O.I., Hofestaedt R., Dosenko V.E. MOLECULAR RELATIONSHIPS BETWEEN BRONCHIAL ASTHMA AND HYPERTENSION AS COMORBID DISEASES. Journal of integrative bioinformatics. 2018. Т. 15. № 4. 17. Babushkina N.P., Bragina E.Y., Garaeva A.F., Goncharova I.A., Rudko A.A., Freidin M.B., Tcitrikov D.Y., Gomboeva D.E. VALIDATION OF THE RESULTS OF GENOME-WIDE ASSOCIATION STUDIES OF TUBERCULOSIS IN RUSSIANS OF WEST SIBERIA/ Russian Journal of Genetics. 2018. Т. 54. № 1. С. 103-109. 18. Babushkina N.P., Kucher A.N., Bragina E.Y., Garaeva A.F., Goncharova I.A., Tcitrikov D.Y., Gomboeva D.E., Rudko A.A., Freidin M.B. ETHNIC AND GEOGRAPHICAL ASPECTS OF THE PREVALENCE OF THE POLYMORPHIC VARIANTS OF GENES ASSOCIATED WITH TUBERCULOSIS. Russian Journal of Genetics. 2018. Т. 54. № 9. С. 1089-1100. 19. Zolotareva O., Saik O.V., Ivanisenko V.A., Königs C., Hofestädt R., Bragina E.Y., Goncharova I.A., Freidin M.B., Dosenko V.E.COMORBIDITY OF ASTHMA AND HYPERTENSION MAY BE MEDIATED BY SHARED GENETIC DYSREGULATION AND DRUG SIDE EFFECTS/ Scientific Reports. 2019. Т. 9. № 1. С. 16302. 20. I. A. Goncharovaa, b, *, M. S. Nazarenkoa, b, c, N. P. Babushkinaa, A. V. Markova, T. B. Pecherinab,V. V. Kashtalapb, N. V. Tarasenkoa, c, A. B. Ponasenkob, O. L. Barbarashb, and V. P. Puzyreva. Genetic Predisposition to Early Myocardial Infarction. Molecular Biology, 2020, Vol. 54, No. 2, pp. 196–203 |