Golubenko, Maria Vladimirovna
Candidate degree (PhD) in biological sciences, 1998. Senior researcher in the laboratory of population genetics in the Research Institute of Medical Genetics, Tomsk NRMC.Contact information
e-mail maria-golubenko medgenetics.ruTel. +79039134409
Fax: +7 (3822) 51-37-44
Education and career
Maria Golubenko graduated with honors from the Biology and Soil Department of Tomsk State University (Department of Cytology and Genetics, Department of Applied Informatics), in 1996. She has been working at the Research Institute of Medical Genetics since 1996, and as a senior research fellow since 2008. The candidate of sciences (PhD) dissertation was entitled “Mitochondrial DNA polymorphism in the aboriginal population of the Tuva Republic” (1998). In 2000-2003 worked as postdoctoral fellow in the Estonian Biocenter (Tartu) on the study of mitochondrial DNA polymorphism in populations of Russia, and in the Institute for physiological and clinical research of the Max-Planck Society (Bad Nauheim) on the genetics of hypertrophic cardiomyopathy.Research interests
Different aspects of human mitochondrial genetics, in particular mtDNA polymorphism in different human populations and mtDNA role in the development of common diseases. In addition, research interests include genetics of cardiomyopathies and cardiovascular genetics, as well as population and evolutionary genetics.Achievements and grants
Scientific leader of the following research projects:RFBR grants
04-04-48792a “Characteristics of the mitochondrial gene pool of Siberian peoples populations with accounting for modern migration processe” (2004-2006);
07-04-01526a “Assessment of the mtDNA polymorphism contribution to the development of cardiovascular system phenotypes in humans” (2007-2009);
16-04-01481а “Epigenetic relationship between mitochondrial and nuclear genomes in atherosclerosis” (2016-2018); 19-04-01322 “Assessment of adaptive characteristics of human mitochondrial DNA polymorphism”.
Federal Target Programs for research and development in priority areas of science and technology
Contract no. 02.442.11.7076 “Description of the variability of the candidate gene for hypertrophic cardiomyopathy (MYBPC3) in human populations of different ethnic origin“ (2005);
Contract no. 02.442.11.7350 “The study of the contribution of human mitochondrial DNA polymorphism to the variability of the cardiovascular system traits in normal and pathological conditions” (2006).
Federal Target Programs for research and pedagogical personnel for innovative Russia
Contract no. П977 by 20.08.2009 “Development of oligonucleotide biosensors for detection of genomic variants with pharmacogenetic effects in cardiovascular diseases” (2009-2011).
Main Publications:
1. Saliukov VB, Puzyrev VP, Golubenko MV, Kutmin AI. Polimorfizm nekodiruiushchikh oblasteĭ mitokhondrial'nogo genoma u korennogo naseleniia iugo-vostoka Tuvy [Polymorphism of noncoding regions of the mitochondrial genome in the indigenous population of Southeastern Tuva Republic]. Genetika. 1998;34(10):1420‐1424.2. Golubenko MV, Puzyrev VP, Saliukov VB, Kucher AN, Sanchat NO. Restriktsionnyĭ polimorfizm glavnogo nekodiruiushchego raĭona mtDNK u korennogo naseleniia respubliki Tuva [Restriction polymorphism of the major noncoding region of mtDNA in the indigenous population of the TUVA republic]. Genetika. 1999;35(8):1124‐1131.
3. Puzyrev VP, Stepanov VA, Golubenko MV, et al. Linii mtDNK i Y-khromosomy v populiatsii iakutov [MtDNA and Y-chromosome lineages in the Yakut population]. Genetika. 2003;39(7):975‐981.
4. Puzyrev VP, Golubenko MV, Freĭdin MB. Sfera kompetentsii mitokhondral'noĭ genetiki [The realm of mitochondrial genetics competence]. Vestn Ross Akad Med Nauk. 2001;(10):31‐37.
5. Waldmueller S., Sakthivel S., Saadi A.V., Selignow C., RAkesh P.G., Golubenko M., Joseph P.K., Padmakumar R., Richard P., Schwarz K., Tharakan J.M., Rajamanikam C., Vosberg H-P. Novel deletions in MYH7 and MYBPC3 identified in Indian families with familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2003;35(6):623‐636. doi:10.1016/s0022-2828(03)00050-6.
6. Reidla M., Kivisild T., Metspalu E., Kaldma K., Tambets K., Tolk H-V, Parik J., Loogvali E-L.., Derenko M.V., Malyarchuk B.A., Bermisheva M., Zhadanov S., Pennarun E., Gubina M., Golubenko M., Damba L., Fedorova S., Gusar V., Mikerezi I., Moisan J.P., Khusnutdinova E., Ossipova L., Stepanov V., Voevoda M., Achilli A., Rengo C., Rickards O., De Stefano G.F., Papiha S., Beckman L., Rudan P., Anagnou N.P., Koziel S., Usanga E., Geberhiwot T., Herrnstadt C.J., Torroni A., Villems R. Origin and diffusion of mtDNA haplogroup X. Am J Hum Genet. 2003;73(5):1178‐1190. doi:10.1086/379380.
7. Loogväli EL, Roostalu U, Malyarchuk BA, Derenko MV, Kivisild T, Metspalu E, Tambets K, Reidla M, Tolk HV, Parik J, Pennarun E, Laos S, Lunkina A, Golubenko M., Barac L, Pericic M, Balanovsky OP, Gusar V, Khusnutdinova EK, Stepanov V, Puzyrev V, Rudan P, Balanovska EV, Grechanina E, Richard C, Moisan JP, Chaventré A, Anagnou NP, Pappa KI, Michalodimitrakis EN, Claustres M, Gölge M, Mikerezi I, Usanga E, Villems R. Disuniting uniformity: a pied cladistic canvas of mtDNA haplogroup H in Eurasia. Mol Biol Evol. 2004;21(11):2012‐2021. doi:10.1093/molbev/msh209
8. Makeeva OA, Puzyrev KV, Pavliukova EN, Koshel'skaia OA, Golubenko MV, Efimova EV, Kucher AN, Tsimbaliuk IV, Karpov RS, Puzyrev VP. Polimorfizm genov ACE i AGTR1 v patogeneze gipertorofii levogo zheludochka serdtsa u cheloveka [ACE and AGTR1 genes polymorphisms in left ventricular hypertrophy pathogenesis in humans]. Mol Biol (Mosk). 2004;38(6):990‐996.
9. Buĭkin SV, Golubenko MV, Pogrebenkova VV, Tsimbaliuk IV, Puzyrev VP. [Gene of Mitochondrial DNA Gamma-Polymerase (POLG): Frequency and Linkage Disequilibrium of Two SNP's in Siberian Populations] Mol Biol (Mosk). 2006;40(6):1081‐1083.
10. Tamm E, Kivisild T, Reidla M, Metspalu M, Smith DG, Mulligan CJ, Bravi CM, Rickards O, Martinez-Labarga C, Khusnutdinova EK, Fedorova SA, Golubenko MV, Stepanov VA, Gubina MA, Zhadanov SI, Ossipova LP, Damba L, Voevoda MI, Dipierri JE, Villems R, Malhi RS. Beringian standstill and spread of Native American founders. PLoS One. 2007;2(9):e829. doi:10.1371/journal.pone.0000829
11. Kaput J, Cotton RG, Hardman L, Watson M, Al Aqeel AI, Al-Aama JY, Al-Mulla F, Alonso S, Aretz S, Auerbach AD, Bapat B, Bernstein IT, Bhak J, Bleoo SL, Blöcker H, Brenner SE, Burn J, Bustamante M, Calzone R, Cambon-Thomsen A, Cargill M, Carrera P, Cavedon L, Cho YS, Chung YJ, Claustres M, Cutting G, Dalgleish R, den Dunnen JT, Díaz C, Dobrowolski S, dos Santos MR, Ekong R, Flanagan SB, Flicek P, Furukawa Y, Genuardi M, Ghang H, Golubenko MV, Greenblatt MS, Hamosh A, Hancock JM, Hardison R, Harrison TM, Hoffmann R, Horaitis R, Howard HJ, Barash CI, Izagirre N, Jung J, Kojima T, Laradi S, Lee YS, Lee JY, Gil-da-Silva-Lopes VL, Macrae FA, Maglott D, Marafie MJ, Marsh SG, Matsubara Y, Messiaen LM, Möslein G, Netea MG, Norton ML, Oefner PJ, Oetting WS, O'Leary JC, de Ramirez AM, Paalman MH, Parboosingh J, Patrinos GP, Perozzi G, Phillips IR, Povey S, Prasad S, Qi M, Quin DJ, Ramesar RS, Richards CS, Savige J, Scheible DG, Scott RJ, Seminara D, Shephard EA, Sijmons RH, Smith TD, Sobrido MJ, Tanaka T, Tavtigian SV, Taylor GR, Teague J, Töpel T, Ullman-Cullere M, Utsunomiya J, van Kranen HJ, Vihinen M, Webb E, Weber TK, Yeager M, Yeom YI, Yim SH, Yoo HS; Contributors to the Human Variome Project Planning Meeting. Planning the human variome project: the Spain report. Hum Mutat. 2009;30(4):496‐510. doi:10.1002/humu.20972
12. Buĭkin SV, Golubenko MV, Puzyrev VP. ["Genes for Mitochondria" in Arterial Hypertension and Left Ventricular Hypertrophy] Mol Biol (Mosk). 2010;44(1):28‐32. doi:10.1134/s002689331001005x
13. Zeĭkova TV, Golubenko MV, Buĭkin SV, Botkina OIu, Makeeva OA, Lezhnev AA, Kalianov EV, Tsimbaliuk IV, Maksimov VN, Voevoda MI, Shipulin VM, Puzyrev VP [The Glutathione Peroxidase 1 (GPX1) Single Nucleotide Polymorphism pro198Leu: Association With Life Span and Coronary Artery Disease]. Mol Biol (Mosk) . May-Jun 2012;46(3):481-6.
14. Makeeva OA, Zykov MV, Golubenko MV, Kashtalap VV, Kuslish EV, Goncharova IA, Barbarash OL, Puzyrev VP. [The Role of Genetic Factors in the Prediction of Myocardial Infarction Complications Within One Year Follow Up] Kardiologiia. 2013;53(10):16‐23
15. Zheĭkova TV, Golubenko MV, Buĭkin SV, Botkina OIu, Tsimbaliuk IV, Maksimov VN, Voevoda MI, Puzyrev VP. [Association Between 242C > T Polymorphism of NADPH Oxidase p22phox Gene (CYBA) and Longevity in Russian Population] Genetika. 2013 Mar;49(3):410-4. doi: 10.7868/s0016675813020136.
16. Salakhov RR, Goncharova IA, Makeeva OA, Golubenko MV, Kulish EV, Kashtalap VV, Barbarash OL, Puzyrev VP. [TOMM40 Gene Polymorphism Association With Lipid Profile] Genetika. 2014;50(2):222‐229.
17. Golubenko MV, Salakhov RR, Makeeva OA, Goncharova IA, Kashtalap VV, Barbarash OL, Puzyrev VP. [Mitochondrial DNA Polymorphism Association With Myocardial Infarction and Prognostic Signs for Atherosclerosis] Mol Biol (Mosk). 2015;49(6):968‐976. doi:10.7868/S0026898415050080
18. Goncharova IA, Makeeva OA, Golubenko MV, Markov AV, Tarasenko NV, Sleptsov AA, Puzyrev VP. [Genes for Fibrogenesis in the Determination of Susceptibility to Myocardial Infarction] Mol Biol (Mosk). 2016;50(1):94‐105. doi:10.7868/S0026898415060099
19. Zykov MV, Makeeva OA, Golubenko MV, Kashtalap VV, Kulish EV, Bykova IS, Kalaeva VV, Karetnikova VN, Barbarash OL, Puzyrev VP. [The Study of Associations of Polymorphisms of Candidate Gene of Cardiovascular Diseases With Reduction of Glomerular Filtration Rate in Patients With ST Segment Elevation Myocardial Infarction]. Kardiologiia. 2016;56(2):11‐18. doi:10.18565/cardio.2016.2.11-18
20. Golubenko MV, Nazarenko MS, Frolov AV, Sleptsov AA, Markov AV, Glushkova ME, Barbarash OL, Puzyrev VP. [Analysis of Heteroplasmy in the Major Noncoding Region of Mitochondrial DNA in the Blood and Atherosclerotic Plaques of Carotid Arteries]. Genetika. 2016;52(4):497‐502.
21. Pankratov V, Litvinov S, Kassian A, Shulhin D, Tchebotarev L, Yunusbayev B, Möls M, Sahakyan H, Yepiskoposyan L, Rootsi S, Metspalu E, Golubenko M, Ekomasova N, Akhatova F, Khusnutdinova E, Heyer E, Endicott P, Derenko M, Malyarchuk B, Metspalu M, Davydenko O, Villems R, Kushniarevich A. East Eurasian ancestry in the middle of Europe: genetic footprints of Steppe nomads in the genomes of Belarusian Lipka Tatars. Sci Rep. 2016;6:30197. Published 2016 Jul 25. doi:10.1038/srep30197
22. Nazarenko MS, Sleptcov AA, Lebedev IN, Skryabin NA, Markov AV, Golubenko MV, Koroleva IA, Kazancev AN, Barbarash OL, Puzyrev VP. Genomic structural variations for cardiovascular and metabolic comorbidity. Sci Rep. 2017;7:41268. Published 2017 Jan 25. doi:10.1038/srep41268
23. Sahakyan H, Hooshiar Kashani B, Tamang R, Kushniarevich A, Francis A, Costa MD, Pathak AK, Khachatryan Z, Sharma I, van Oven M, Parik J, Hovhannisyan H, Metspalu E, Pennarun E, Karmin M, Tamm E, Tambets K, Bahmanimehr A, Reisberg T, Reidla M, Achilli A, Olivieri A, Gandini F, Perego UA, Al-Zahery N, Houshmand M, Sanati MH, Soares P, Rai E, Šarac J, Šarić T, Sharma V, Pereira L, Fernandes V, Černý V, Farjadian S, Singh DP, Azakli H, Üstek D, Ekomasova Trofimova N, Kutuev I, Litvinov S, Bermisheva M, Khusnutdinova EK, Rai N, Singh M, Singh VK, Reddy AG, Tolk HV, Cvjetan S, Lauc LB, Rudan P, Michalodimitrakis EN, Anagnou NP, Pappa KI, Golubenko MV, Orekhov V, Borinskaya SA, Kaldma K, Schauer MA, Simionescu M, Gusar V, Grechanina E, Govindaraj P, Voevoda M, Damba L, Sharma S, Singh L, Semino O, Behar DM, Yepiskoposyan L, Richards MB, Metspalu M, Kivisild T, Thangaraj K, Endicott P, Chaubey G, Torroni A, Villems R. Origin and spread of human mitochondrial DNA haplogroup U7. Sci Rep. 2017;7:46044. Published 2017 Apr 7. doi:10.1038/srep46044