Paderina (Osmanova) Diana
Paderina (Osmanova) Diana Z., researcher, Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center.
Contacts Details
e-mail: osmanovadiana@mail.ru
tel.: +7 (3822) 72-38-32
Brief Biography
Paderina Diana Zakirovna studied at the National Research Tomsk State University (NR TSU), where she received a bachelor's degree (2014) and a master's degree (2016) in the specialty "Biology". She graduated from the postgraduate course of the Tomsk State University of the Faculty of Biology in the direction of preparation "Biological Sciences", specialty "Genetics" in 2020.
She has been working in the team of the Mental Health Research Institute since 2014. In 2015, she completed an internship at the workplace in the Institution of Genomic Analysis, Laboratory of Genetics of the University of Groningen (Netherlands).
Diana Zakirovna is a member of the youth section of the Russian National Consortium for Psychiatric Genetics, a member of the Society for Pharmacogenetics, Pharmacokinetics and Personalized Therapy.
Research Interests
Genetics, molecular biology, pharmacogenetics, mental and neurodegenerative diseases.
Achievements, Awards, Grants
Diana Zakirovna is the author and co-author of more than 90 publications in the central and regional press (including abstracts and conference materials), of which 20 articles in journals listed by the Higher Attestation Commission, more than 30 articles in Web of Science and Scopus, 4 certificates of state registration of databases and 2 certificate of registration of a computer program.
D.Z. Paderina took part in more than 20 scientific conferences and congresses at various levels with oral and poster presentations in Russia and the countries of the European Union. She was repeatedly awarded diplomas of various degrees for the best reports, and also became the winner of competitions for young scientists (29th ECNP Congress, CDE Grant winner (Vienna, Austria; 2016); 30th ECNP Congress, CDE Grant winner (Paris, France; 2017); 33th ECNP Congress Virtual 2020, CDE Grant Winner). Laureate of the competition for the Presidential Scholarship (2018-2020) (PS-2478.2018.4) for young scientists and graduate students carrying out promising research and development in priority areas of modernization of the Russian economy on the topic "Association of polymorphic variants of genes of the dopaminergic and serotonergic systems with the development of neuroleptic hyperprolactinemia in patients with schizophrenia". Prize Winner of Tomsk Region in the field of Education, Science, Health Care and Culture (2021).
D.Z. Paderina was an investigator in the following projects:
1. Russian Science Foundation (RSF) grant no. 14-35-00023 "Laboratory of pharmacogenetic studies of personalized therapy for mental and neurodegenerative disorders" (2014-2016);
2. Russian Foundation for Basic Research (RFBR) grant no. 17-29-02205 "Development of a molecular genetic panel of depressive disorders based on polymorphisms of genes of neuronal kinases, neurotrophic proteins and genes of the serotonergic system" (2017-2020);
3. RSF grant no. 17-75-10055 "Pharmacogenetics of tardive dyskinesia in schizophrenia: the role of polymorphisms in the genes of muscarinic, adrenergic and glutamate receptors" (2017 - 2019);
4. RFBR grant no. 17-29-06035 "New approaches to the pharmacogenetics of antipsychotic-induced hyperprolactinemia in patients with schizophrenia" (2017-2019);
5. Integration project of the Siberian Branch of the Russian Academy of Sciences "An integrated approach to the creation of a new generation of antipsychotics" (2018-2020);
6. RSF grant no. 19-75-10012 "New approaches to the pharmacogenetics of the metabolic syndrome in schizophrenia" (2019-2021);
7. RSF grant no. 21-15-00212 "The role of DNA methylation and polymorphism of the glutamatergic system genes in the clinic, cognitive deficit and therapy of schizophrenia" (2021-2023);
8. RSF grant no. 23-75-10072 "BDNF-mediated intracellular signaling cascades in clinical polymorphism and cognitive deficits in schizophrenia" (2023-2026).
Key Papers
1. Mednova I.A., Pozhidaev I.V., Tiguntsev V.V., Bocharova A.V., Paderina D.Z., Boiko A.S., Fedorenko O.Y., Kornetova E.G., Bokhan N.A., Stepanov V.A., Ivanova S.A. NOS1AP Gene Variants and Their Role in Metabolic Syndrome: A Study of Patients with Schizophrenia // Biomedicines, 2024, 12(3):627.
2. Poltavskaya E.G., Kornetova E.G., Freidin M.B., Pozhidaev I.V., Paderina D.Z., Bocharova A.V., Semke A.V., Bokhan N.A., Ivanova S.A., Fedorenko O.Y. The Role of Glutamatergic Gene Polymorphisms in the Clinical Phenotypes of Schizophrenia // Genes, 2023, Vol.14, № 3, P. 575.
3. Paderina D.Z., Boiko A.S., Pozhidaev I.V., Mednova I.A., Goncharova A.A., Bocharova A.V., Fedorenko O.Y., Kornetova E.G., Semke A.V., Bokhan N.A., Loonen A.J.M., Ivanova S.A. The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia // Genes (Basel), 2022, Vol. 13(8), 1312.
4. Fedorenko O.Y., Paderina D.Z., Kornetova E.G., Poltavskaya E.G., Pozhidaev I.V., Goncharova A.A., Freidin M.B., Bocharova A.V., Bokhan N.A., Loonen A.J.M., Ivanova S.A. Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia // Diagnostics (Basel), 2022, Vol. 12(7), 1521.
5. Boiko A.S., Pozhidaev I.V., Paderina D.Z., Mednova I.A., Goncharova A.A., Fedorenko O.Y., Kornetova E.G., Semke A.V., Bokhan N.A., Loonen A.J.M., Ivanova S.A. Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome // Genes (Basel), 2022, Vol. 13(5): 844.
6. Paderina D.Z., Boiko A.S., Pozhidaev I.V., Bocharova A.V., Mednova I.A., Fedorenko O.Y., Kornetova E.G., Loonen A.J.M., Semke A.V., Bokhan N.A., Ivanova S.A. Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia // Journal of Personalized Medicine. 2021; 11(3):181.
7. Fedorenko O.Y., Paderina D.Z., Loonen A.J.M., Pozhidaev I.V., Boiko A.S., Kornetova E.G., Bokhan N.A., Wilffert B., Ivanova S.A. Association of ANKK1 polymorphism with antipsychotic-induced hyperprolactinemia // Hum Psychopharmacol. 2020 May 8: e2737.
8. Ivan V. Pozhidaev, Anastasiia S. Boiko, Anton J.M. Loonen, Diana Z. Paderina, Olga Yu. Fedorenko, Gennadiy Tenin, Elena G. Kornetova, Arkadiy V. Semke, Nikolay A. Bokhan, Bob Wilffert, Svetlana A. Ivanova. Association of Cholinergic Muscarinic M4 Receptor Gene Polymorphism with Schizophrenia // The Application of Clinical Genetics 22 April 2020 Volume 2020:13, Pages 97-105.
9. Boiko A.S., Ivanova S.A., Pozhidaev I.V., Freidin M.B., Osmanova D.Z., Fedorenko O.Y., Semke A.V., Bokhan N.A., Wilffert B., Loonen A.J.M. Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors // World J Biol Psychiatry. 2020 Jan;21(1):72-77.
10. Paderina D.Z., Freidin M.B., Fedorenko O.Yu., Stegniy V.N., Ivanova S.A. Prognostic model of the risk of hyperprolactinemia in patients with schizophrenia on the background of antipsychotic therapy // Medical genetics. – 2020. –T. 19. – No. 2 (211). – P. 11-16 (in Russian).
11. Semkina A.A., Osmanova D.Z., Alifirova V.M., Titova M.A., Koroleva E.S., Ivanova S.A. Association of polymorphic variants of the brain-derived neurotrophic factor gene (BDNF rs6265) and type 2 glutamate transporter gene (SLC1A2 rs4354668) with the course of multiple sclerosis in patients living in the Tomsk Region // Bulletin of RAMS. – 2019. – Vol.74(1). – P. 14–19 (in Russian).
12. D.Z. Osmanova, M.B. Freidin, O.Yu. Fedorenko, I.V. Pozhidaev, A.S. Boiko, N. M. Vyalova, V.V. Tiguntsev, E.G. Kornetova, A.J.M. Loonen, A.V. Semke, B. Wilffert, N.A. Bokhan, S.A. Ivanova. A pharmacogenetic study of patients with schizophrenia from West Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia // BMC Medical Genetics, 2019, 20 (Suppl 1) :47.
13. Taichi Ochi, Natalya M. Vyalova, Innokentiy S. Losenkov, Lyudmila A. Levchuk, Diana Z. Osmanova, Ekaterina V. Mikhalitskaya, Anton J.M. Loonen, Fokko J. Bosker, German G. Simutkin, Nikolay A. Bokhan, Bob Wilffert, Svetlana A. Ivanova. Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: a prospective inception cohort study in treatment-free patients // Journal of Affective Disorders, 2019, Volume 259, P. 432-439.
14. Boiko AS, Ivanova SA, Pozhidaev IV, Freidin MB, Osmanova DZ, Fedorenko OY, Semke AV, Bokhan NA, Wilffert B, Loonen AJM Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors // World J Biol Psychiatry. 2019 Jan 9:1-6.
15. Parkinson's disease and polymorphisms of the genes of the glutamatergic system GRIN2A, SLC1A2 and GRIK4 / Mironova Yu.S., Zhukova I.A., Zhukova N.G., Ivanova S.A., Alifirova V.M., Boyko A.S., Osmanova D.Z., Izhboldina O.P., Latypova A.V. // Neurology, Neuropsychiatry, Psychosomatics. – 2018. – No. 10(2). – P. 27–32 (in Russian).
16. Antipsychotic-induced hyperprolactinemia: pharmacogenetic aspects / Ivanova S.A., Osmanova D.Z., Boyko A.S., Pozhidaev I.V., Fedorenko O.Yu., Vyalova N.M., Poltavskaya E.G., Tiguntsev V.V., Freidin M.B., Kornetova E.G., Semke A.V. // Siberian Herald of Psychiatry and Addiction Psychiatry. – 2018. – No. 2. – P. 21–27 (in Russian).
17. S.A. Ivanova, D.Z. Osmanova, A.S. Boiko, I.V. Pozhidaev, M.B. Freidin, O.Yu. Fedorenko, A.V. Semke, N.A. Bokhan, E.G. Kornetova, L.D. Rakhmazova, B. Wilffert, A.J.M. Loonen Prolactin gene polymorphism (−1149 G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics // Schizophrenia Research. – 2017. – Vol. 182. – P. 110–114.
18. S.A. Ivanova, D.Z. Osmanova, M.B. Freidin, O.Yu. Fedorenko, A.S. Boiko, I.V. Pozhidaev, A.V. Semke, N.A. Bokhan, A.A. Agarkov, B. Wilffert, A.J.M. Loonen Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia // World Journal of Biological Psychiatry. – 2017. – Р.239–246.