Personalities

Olga Y. Fedorenko

The Gratitude of the Ministry of Science and Higher Education of the Russian Federation and the Certificate of Honor of the Administration of the Tomsk Region for high achievements and success in work (2022); the Honorary Diploma of the Tomsk National Research Medical Center of the Russian Academy of Sciences (2021); the medal "Honored Veteran of the SB RAS" (2020); the letter of thanks from the Administration of the city of Tomsk for conscientious long-term work, high professional level and in connection with the Day of the Medical Worker (2020); Laureate of the Tomsk Region Administration Prize in the field of education, science, healthcare and culture in the nomination "Awards to scientific and scientific-pedagogical workers who have made a significant personal contribution to the development of science and education" among professors (2017); honored by the Council of Rectors of Tomsk Region Universities for a significant contribution to the development of medical science, many years of fruitful professional activity (2015); winner of the anniversary medal "70 years of the Tomsk Region" (2014); holder of the title "Federal Labor Veteran" (2011); laureate of the competition for young scientists held in honor of the 40th anniversary of the Siberian Branch of the Russian Academy of Medical Sciences (for a research in the field of experimental medicine) (2010); laureate of the competition of the administration of the Tomsk Region in the field of education and science, healthcare and culture as part of the team of authors (for the study "Mechanisms of apoptosis under conditions of oxidative stress in mental and substance use disorders") (2009); laureate of the competition of the administration of the Tomsk Region among young scientists in the field of science and education (2005); was awarded the Certificate of Honor of the Russian Academy of Medical Sciences (2011), the Siberian Branch of the Russian Academy of Medical Sciences (2010), the Administration of the Tomsk Region (2010), the Tomsk Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences (2007), the Mental Health Research Institute (2001).

Principal Investigator of seven grants:

1. Russian Science Foundation no. 21-15-00212 (2021-2023) "The role of DNA methylation and polymorphism of the glutamatergic system genes in the clinic, cognitive deficit and therapy of schizophrenia";

2. Contract with TSU No. 5909 dated November 18, 2021 for the implementation of research work “Study of associations of polymorphic variants of the TENM4, ATXN1, PTPN5 genes and a genetic marker near the ACP1 gene with clinical polymorphism of schizophrenia and the development of antipsychotic-induced tardive dyskinesia and hyperprolactinemia”, 2021;

3. Contract with TSU no. 17092 dated December 7, 2020 for the implementation of research work “Study of associations of polymorphic variants of the P-glycoprotein gene with clinical polymorphism of schizophrenia”, 2020;

4. Russian Science Foundation no. 14-35-00023 (2014-2016) "Laboratory for pharmacogenetic studies of personalized therapy for mental and neurodegenerative disorders";

5. Russian Foundation for Basic Research no. 12-04-33072 (2013-2014) “Pathogenesis of movement disorders in patients with endogenous mental disorders during antipsychotic therapy: the role of pharmacogenetic factors”;

6. FTP, State contract no. 8140 (2012-2013) "Development of a complex of markers of major socially significant mental disorders based on the study of molecular genetic mechanisms of dysregulation of neuronal protein kinase signaling pathways";

7. RFBR no. 12-04-01317-а (2012–2013) “The role of SGK1 and CLCNKB gene polymorphisms in the pathophysiology of mental disorders”.

Investigator of 14 grants:

1. RSF no. 19-75-10012 (2019-2021) "New approaches to the pharmacogenetics of the metabolic syndrome in schizophrenia";

2. Contract with TSU no. 17093 dated December 7, 2020 for the implementation of research work “The role of associations of polymorphic variants of the multidrug resistance protein 1 gene in the pathogenesis of drug-induced tardive dyskinesia in schizophrenia”, 2020;

3. Contract with TSU no. 6045 dated June 27, 2019 for the implementation of research work “The role of polymorphic variants of serotonin receptor genes in the development of antipsychotic-induced tardive dyskinesia in schizophrenia”, 2019;

4. RFBR no. 18-315-20019 (2018-2019) "New approaches to the genetics of clinical polymorphism and neurocognitive deficit in schizophrenia";

5. Contract with TSU no. 6345 dated July 13, 2018 for the implementation of research work "Search for associations of the KREMEN1, ANKK1, RGS2 genes of proteins of intracellular signaling pathways with schizophrenia and side effects of antipsychotic psychopharmacotherapy", 2018;

6. RFBR no. 17-29-06035 (2017-2019) "New approaches to the pharmacogenetics of antipsychotic-induced hyperprolactinemia in patients with schizophrenia";

7. Contract with TSU no. 5007 dated June 22, 2017 for the implementation of research “The role of neurotransmitter transporter gene polymorphisms in the development of drug-induced movement disorders in schizophrenia and Parkinson's disease”, 2017;

8. Contract with TSU no. 4110 dated August 25, 2016 for the implementation of research work "Study of the association of polymorphism of neurotransmitter system transporter genes in patients with depressive spectrum disorders with a response to antidepressant therapy", 2016;

9. Contract with TSU no. 3855 dated July 07, 2015 for the implementation of research work “Study of associations of neurotransmitter system transporter gene polymorphisms in patients with schizophrenia with side effects of antipsychotic therapy (hyperprolactinemia)”, 2015;

10. RSF no. 14-15-00480 (2014-2016) "Search for key biomarkers of the pathogenesis of socially significant endogenous mental disorders";

11. Russian Humanitarian Foundation no. 14-06-00531-a (2014-2016) “Psychosocial, ethnocultural and genetic determinants of alcohol addiction among representatives of the indigenous population of Siberia”;

12. Russian Foundation for Basic Research no. 11-04-01102-а (2011–2013) “Studying the association of PIP5K2A kinase gene polymorphism with socially significant mental and behavioral disorders”;

13. FTP, State Contract no. K-16-NIR/46-8 (2010) "Development of methods for assessing the quality of specialized medical care for patients with mental disorders based on the use of clinical, immunophysiological and biochemical criteria";

14. FTP, State Contract no. 06/957 (2007) "Clinical-immunological, immuno-physiological and molecular-biological mechanisms of pathogenetic therapy of mental disorders" within the framework of the subprogram "Mental disorders" of the FTP "Prevention and control of socially significant diseases (2007-2011)".

Monographs and Chapters in Monographs

1. Fedorenko O.Yu., Losenkov I.S. Neuroprotective systems in schizophrenia // In the book: Biological markers of schizophrenia: search and clinical application Boiko A.S., Bokhan N.A., Buneva V.N., Vetlugina T.P., Zozulya S.A., Ivanova S.A., Klyushnik T. P., Kornetova E.G., Losenkov I.S., Oleichik I.V., Semke A.V., Smirnova L.P., Uzbekov M.G., Fedorenko O.Yu. Novosibirsk, 2017, pp. 105-130 (in Russian).

2. A.S. Boyko, N.A. Bokhan, V.N. Buneva, T.P. Vetlugina, S.A. Zozulya, S.A. Ivanova, T.P. Klyushnik, E.G. Kornetova, I.S. Losenkov, I.V. Oleinik, A.V. Semke, L.P. Smirnova, M.G. Uzbekov, O.Yu. Fedorenko Biological markers of schizophrenia: search and clinical application / N.A. Bokhan, S.A. Ivanova, eds. - Novosibirsk: Publishing House of the Siberian Branch of the Russian Academy of Sciences, 2017. -148 p. ISBN 978-5-7692-1513-1 (in Russian).

3. Ivanova S.A., Fedorenko O.Yu., Bokhan N.A., A. Loonen Pharmacogenetics of tardive dyskinesia. - Tomsk: Publishing House "New Printing Technologies", 2015. - 120 p. (in Russian).

4. Fedorenko O.Yu., Ivanova S.A., Bokhan N.A. Genetic disorders of protein kinases in mental disorders in the PIP5K2A, SGK1 and GSK-3β model. Saarbrücken: Palmarium Academic Publishing, 2013. - 85 p. (in Russian).

5. Dobrzynski H., Monfredi O., Greener I. D., Atkinson A., Inada S., Taube M.-A., Yanni J., Fedorenko O., Molenaar P., Anderson R. H., Efimov I. R., Boyett M. R. Molecular basis of the electrical activity of the atrioventricular junction and Purkinje fibers. Chapter 17 in: Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation and Clinical Implications. Onkar Tripathi, Ursula Ravens, Mike Sanguinetti, eds. 2011. — P. 211—230.

6. Fedorenko O. Yu., Semke A. V., Ivanova S. A. Leukocyte apoptosis and the level of dehydroepiandrosterone in schizophrenia // Chapter in the collective monograph "Pathophysiology of mental disorders". - Tomsk: Ph. SI MHRI TSC SB RAMS, 2006. — P. 97–109 (in Russian).

Key Publications

Web of Science h-index – 15, RSCI – 20.

The total number of publications is more than 200, of which 50 articles are in the international journals.

1. Fedorenko O.Yu., Mikhalitskaya E.V., Toshchakova V.A., Loonen A.J.M., Bokhan N.A., Ivanova S.A. Association of PIP4K2A Polymorphisms with Alcohol Use Disorder // Genes. 2021, 12(10), 1642; https://doi.org/10.3390/genes12101642 (WoS IF 4.096).

2. Boiko AS, Pozhidaev IV, Paderina DZ, Bocharova AV, Mednova IA, Fedorenko OY, Kornetova EG, Loonen AJM, Semke AV, Bokhan NA, Ivanova SA. Search for Possible Associations of FTO Gene Polymorphic Variants with Metabolic Syndrome, Obesity and Body Mass Index in Schizophrenia Patients // Pharmgenomics Pers Med. 2021 Sep 7;14:1123-1131. doi: 10.2147/PGPM.S327353. eCollection 2021. (WoS IF 3,724).

3. Paderina D.Z., Boiko A.S., Pozhidaev I.V., Bocharova A.V., Mednova I.A., Fedorenko O.Yu., Kornetova E.G., Loonen A.J.M., Semke A.V., Bokhan N.A., Ivanova S.A. Genetic polymorphisms of 5-HT receptors and antipsychotic-induced metabolic dysfunction in patients with schizophrenia // J Pers Med. 2021 Mar 5;11(3):181. doi: 10.3390/jpm11030181. (WoS IF 4,902).

4. Levchenko A, Kanapin A, Samsonova A, Fedorenko OY, Kornetova EG, Nurgaliev T, Mazo GE, Semke AV, Kibitov AO, Bokhan NA, Gainetdinov RR, Ivanova SA.A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 8;105:110134. doi: 10.1016/j.pnpbp.2020.110134. (WoS IF 4.361).

5. Pozhidaev IV, Paderina DZ, Fedorenko OY, Kornetova EG, Semke AV, Loonen AJM, Bokhan NA, Wilffert B, Ivanova SA.Pozhidaev IV, et al. 5-Hydroxytryptamine Receptors and Tardive Dyskinesia in Schizophrenia // Front Mol Neurosci. 2020 Apr 24;13:63. doi: 10.3389/fnmol.2020.00063. eCollection 2020. (WoS IF 4.057).

6. Pozhidaev IV, Boiko AS, Loonen AJM, Paderina DZ, Fedorenko OY, Tenin G, Kornetova EG, Semke AV, Bokhan NA, Wilffert B, Ivanova SA.Pozhidaev IV, et al. Association of Cholinergic Muscarinic M4 Receptor Gene Polymorphism with Schizophrenia // Appl Clin Genet. 2020 Apr 22;13:97-105. doi: 10.2147/TACG.S247174. eCollection 2020. (WoS IF 3.60).

7. Geers LM, Pozhidaev IV, Ivanova SA, Freidin MB, Schmidt AF, Cohen D, Boiko AS, Paderina DZ, Fedorenko OY, Semke AV, Bokhan NA, Wilffert B, Kosterink JGW, Touw DJ, Loonen AJM.Geers LM, et al. Association between 8 P-glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug-induced hyperprolactinaemia // Br J Clin Pharmacol. 2020 Mar 21;86(9):1827-35. doi: 10.1111/bcp.14288. (WoS IF 3.74).

8. Boiko AS, Ivanova SA, Pozhidaev IV, Freidin MB, Osmanova DZ, Fedorenko OY, Semke AV, Bokhan NA, Wilffert B, Loonen AJM. Pharmacogenetics of tardive dyskinesia in schizophrenia: The role of CHRM1 and CHRM2 muscarinic receptors // World J Biol Psychiatry. 2020 Jan;21(1):72-77. doi: 10.1080/15622975.2018.1548780. (WoS IF 4.225).

9. Fedorenko OY, Golimbet VE, Ivanova SА, Levchenko А, Gainetdinov RR, Semke AV, Simutkin GG, Gareeva АE, Glotov АS, Gryaznova A, Iourov IY, Krupitsky EM, Lebedev IN, Mazo GE, Kaleda VG, Abramova LI, Oleichik IV, Nasykhova YA, Nasyrova RF, Nikolishin AE, Kasyanov ED, Rukavishnikov GV, Timerbulatov IF, Brodyansky VM, Vorsanova SG, Yurov YB, Zhilyaeva TV, Sergeeva AV, Blokhina EA, Zvartau EE, Blagonravova AS, Aftanas LI, Bokhan NА, Kekelidze ZI, Klimenko TV, Anokhina IP, Khusnutdinova EK, Klyushnik TP, Neznanov NG, Stepanov VA, Schulze TG, Kibitov АО. Opening up new horizons for psychiatric genetics in the Russian Federation: moving toward a national consortium // Mol Psychiatry. 2019 Aug;24(8):1099-1111. doi: 10.1038/s41380-019-0354-z. (WoS IF 12.384).

10. Geers LM, Cohen D, Wehkamp LM, van Hateren K, Koster RA, Fedorenko OY, Semke AV, Bokhan N, Ivanova SA, Kosterink JGW, Loonen AJM, Touw DJ. Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine // J Clin Psychiatry. 2017 Nov/Dec;78(9):e1211-e1218. doi: 10.4088/JCP.16m11164. (WoS IF 5.291).

11. Ivanova SA, Osmanova DZ, Freidin MB, Fedorenko OY, Boiko AS, Pozhidaev IV, Semke AV, Bokhan NA, Agarkov AA, Wilffert B, Loonen AJ. Identification of 5-hydroxytryptamine receptor gene polymorphisms modulating hyperprolactinaemia in antipsychotic drug-treated patients with schizophrenia // World J Biol Psychiatry. 2017 Apr;18(3):239-246. doi: 10.1080/15622975.2016.1224926. (WoS IF 4.183).

12. Ivanova SA, Osmanova DZ, Boiko AS, Pozhidaev IV, Freidin MB, Fedorenko OY, Semke AV, Bokhan NA, Kornetova EG, Rakhmazova LD, Wilffert B, Loonen AJ. Prolactin gene polumorphism (-1149G/T) is associated with hyperprolactinemia in patients with schizophrenia treated with antipsychotics // Schizophrenia Research 2017 Apr;182:110—114. doi: 10.1016/j.schres.2016.10.029 (WoS IF 4.453).

13. Ivanova S.A., Toshchakova V.A., Filipenko M.L., Fedorenko O.Y., Boyarko E.G., Boyko A.S., Semke A.V., Bokhan N.A., Aftanas L.I., Loonen A.J.M. Cytochrome P450 1A2 gene polymorphism may diminish tardive dyskinesia by increased inducibility. The World Journal of Biological Psychiatry.- 2015.- V.16.- N.3.- P.200-205 doi: 10.3109/15622975.2014.995222. (WoS IF 4.225).

14. Fedorenko O.Y., Loonen A.J., Lang F., Toshachakova V.A., Boyarko E.G., Semke A.V., Bokhan N.A., Govorin N.V., Aftanas L.I., Ivanova S.A. Association study indicates a protective role of phosphatidylinositol-4-phosphate-5-kinase against tardive dyskinesia // Int J Neuropsychopharmacol. 2015 pii: pyu098. doi: 10.1093/ijnp/pyu098. (WoS IF 5.264).

15. Lou Q., Hansen B.J., Fedorenko O., Csepe T.A., Kalyanasundaram A., Hage L.T., Glukhov A.V., Billman G/E., Weiss R., Mohler P.J., Gyorke S., Biesiadecki B.J., Carnes C.A., Fedorov V.V. Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping // Circulation.- 2014. V. 130. N. 4. P. 315-324. doi: 10.1161/CIRCULATIONAHA. (WoS IF 15.202).  

16. Ivanova S.A., Geers L.M., Al Hadithy A.F., Pechlivanoglou P., Semke A.V., Vyalova N.M., Rudikov E.V., Fedorenko O.Y., Wilffert B., Bokhan N.A., Brouwers J.R., Loonen A.J. Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia // Prog Neuropsychopharmacol Biol Psychiatry.– 2014.– N. 50.– P. 172—177. doi: 10.1016/j.pnpbp.2013.12.015. (WoS IF 4.025). http://www.sciencedirect.com/science/article/pii/S0278584613002959

17. Yanni J., Maczewski M., Mackiewicz U., Siew S.,  Fedorenko O., Atkinson A., Price M., Beresewicz A., Anderson R. H., Boyett M. R.,  Dobrzynski H. Structural and functional alterations in the atrioventricular node and atrioventricular ring tissue in ischaemia-induced heart failure // Histology and Histopathology.– 2014.– N. 7.– P.891—902. doi: 10.14670/HH-29.891. (WoS IF 2.281).

18. Atkinson AJ, Logantha SJ, Hao G, Yanni J, Fedorenko O, Sinha A, Gilbert SH, Benson AP, Buckley DL, Anderson RH, Boyett MR, Dobrzynski H. Functional, anatomical, and molecular investigation of the cardiac conduction system and arrhythmogenic atrioventricular ring tissue in the rat heart // J Am Heart Assoc. – 2013.- V. 2.- N.6:e000246. doi: 10.1161/JAHA.113.000246. (WoS IF 2.882).

19. Ivanova S.A., Al Hadithy A.F., Brazovskaya N., Semke A., Wilffert B., Fedorenko O., Brouwers J.R., Loonen A.J. No involvement of the adenosine A2A receptor in tardive dyskinesia in Russian psychiatric inpatients from Siberia // Hum Psychopharmacol, 2012. — V. 27. N. 3. P. 334—337. doi: 10.1002/hup.2226. (WoS IF 2.5).

20. Ivanova S.A., Loonen A.J.M., Pechlivanoglou P., Freidin M.B., Al Hadithy A.F.Y, Rudikov E.V., Zhukova I.A., Govorin N.V., Sorokina V.A., Fedorenko O., Alifirova V.M., Semke A.V., Brouwers J.R.B.J., Wilffert B. NMDA receptor genotypes associated with the vulnerability to develop dyskinesia // Translational Psychiatry, 2012. — V. 2. — N. 1.: e67; doi:10.1038/tp.2011.66 (www.nature.com/tp). (WoS IF 4.360).
    http://www.nature.com/tp/journal/v2/n1/full/tp201166a.html

21. Al Hadithy A. F. Y., Ivanova S. A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J. R. B. J., Loonen A. J. M. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia // Hum. Psychopharmacol. Clin. ExP. 2010. V. 25. N. 1. P. 84—91. doi: 10.1002/hup.1087. (WoS IF 2.72).

22. Dobrzynski H., Monfredi O., Greener I. D., Atkinson A., Inada S., Taube M.-A., Yanni J., Fedorenko O., Molenaar P., Anderson R. H., Efimov I. R., Boyett M. R. Molecular basis of the electrical activity of the atrioventricular junction and Purkinje fibers. Chapter 17 in: Heart Rate and Rhythm: Molecular Basis, Pharmacological Modulation and Clinical Implications. Editors: Onkar Tripathi, Ursula Ravens, Mike Sanguinetti, 2011. — P. 211—230.

23. Al Hadithy A. F. Y., Ivanova S. A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J. R. B. J., Loonen A. J. M. Missense polymorphisms in three oxidative-stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric inpatients from Siberia // Hum. Psychopharmacol. Clin. ExP. 2010. V. 25. N. 1. P. 84—91. doi: 10.1002/hup.1087. (WoS IF 2.72).

24. 12. Fedorenko O., Tang C., Sopjani M., Foller M., Gehring E.-M., Strutz-Seebohm N., Ureche O. N., Ivanova S., Semke A., Lang F., Seebohm G., Lang U. E.PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3 // Psychopharmacology. 2009. V. 206. N. 3. P. 429—435. doi: 10.1007/s00213-009-1621-5. (WoS IF 3.988).

25. Al Hadithy A.F.Y., Ivanova S.A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya L., Brouwers J.R.B.J., Wilffert B., Bruggeman R., Loonen A.J.M. Tardive dyskinesia and DRD3, HTR2A and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia // Progress in NeuroPsychopharmacology and Biological Psychiatry. 2009. N. 33. P. 475—481. doi: 10.1016/j.pnpbp.2009.01.010. (WoS IF 4.025).

26. Fedorenko O., Strutz-Seebohm N., Henrion U., Ureche O., Seebohm G., Lang F. A., Lang U. E. Schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M-channels in Xenopus oocytes // Psychopharmacology. 2008. V. 199. N. 1. P. 47—54. doi: 10.1007/s00213-008-1095-x. (WoS IF 3.988).

27. Frey A., Lampert A., Dietz K., Striebich S., Locher C., Fedorenko O., Möhle R., Gallinat J., Lang F., Lang U. E. Thyrotropin serum concentrations in healthy volunteers are associated with depression-related personality traits // Neuropsychobiology. 2007. V. 56. N. 2–3. P. 123—126. doi: 10.1159/000112954. (WoS IF 1.992).

28. Strutz-Seebohm N., Seebohm G., Fedorenko O., Baltaev R., Engel J., Knirsch M., Lang F. Functional coassembly of KCNQ4 with KCNE-beta-subunits in Xenopus oocytes // Cell. Physiol. Biochem. 2006. V. 18. N.1–3. P. 57—66. (WoS IF 3.56)

29. Lang K. S., Mueller M. M., Tanneur V., Wallisch S., Fedorenko O., Palmada M., Lang F., Broer S., Heilig C.W., Schleicher E., Weigert C. Regulation of cytosoloc pH and lactic acid release in mesangial cells overexpressing GLUT1// Kidney International. 2003. V.64. N.4.P. 1338—1347. (WoS IF 6.193).

30. Yun C.C., Palmada M., Embark H.M., Fedorenko O., Feng Y., Henke G., Setiawan I., Boehmer C., Weinman E.J., Sandrasagra S., Korbmacher C., Cohen P., Pearce D., Lang. F.The serum and glucocorticoid inducible kinase SGK1 and Na+/H+ exchange regulating factor NHERF2 synergize to stimulate the renal outer medullary K+ channel ROMK1// Journal of the American Society of Nephrology, 2002.— N. 13.— V. 12.— P. 2823—2830. (WoS IF 7.689).