Personalities

Natalia M. Vyalova

Candidate of Biological Sciences, senior researcher of Mental Health Research Institute of Tomsk NRMC.

Contact details

e-mail: Natarakitina@yandex.ru

Phone: +7 (3822) 72-38-32

fax: +7 (3822) 72-44-25

Brief Biography

In 2005 she graduated with honors from Tomsk State University (Department of Cytology and Genetics). In 2003, she was enrolled as a junior research assistant at the Cell and Molecular- Biological Research Laboratory, which was later renamed the Laboratory of Molecular Genetics and Biochemistry. In 2007 she defended her thesis for the degree of candidate of biological sciences in the specialty of “physiology”. Since 2008, she continues to work at Mental Health Research Institute as a researcher and senior researcher. Research Interests

The field of ​​scientific interests of N. M. Vyalova is the study of intracellular kinase signaling pathways in affective disorders, the study of the primary sequence of a number genes of kinase, neurotransmitter and neurotrophic systems using semiconductor sequencing to identify new polymorphic variants associated with the development of depressive disorders. In 2013, the theme of N.M. Vyalova's doctoral dissertation "Disturbance of neuronal protein kinase regulation in affective disorders" (03.02.07. - genetics )was approved.

Achievements, awards, and grants

N.M. Vyalova is the author of more than 100 scientific papers, including 91 publications indexed in the RSCI database and 22 publications in the Web of Science and Scopus databases. She is a co-author of 3 monographs, 6 methodical recommendations and manuals for doctors, 6 patents for the invention of the Russian Federation, 3 new medical technologies. Scientific achievements by N.M. Vyalova won the following awards: laureate of the contest of the Governor of Tomsk Region in the field of education and science (2005), laureate of the international competition of young scientists and specialists “Young Hippocrates” with the award for the basic research (2006), winner of the All-Russian competition of scientific works in the competition “Cytoflavin: New Frontiers ”(2006), winner of the Tomsk Region Competition in the field of education, science, health care and culture” in nomination 3 “Prizes for young scientific and pedagogical workers, specialists, doctoral students and postgraduate students up to 35 years old inclusive ”(2008), winner of the SB RAMS competition among young researchers — candidates of science; according to the results of work in 2006–2008; Fellow of the Regional Charitable Foundation for Assistance to Domestic Medicine (2008–2009); the right to receive scholarships of the President of the Russian Federation to young scientists and graduate students (Competition SP-2015).

For success in the work Vyalova N.M. was awarded the Certificate of Honor of FSBI MHRI SB RAMS (2007), Certificate of Honor of the Siberian Branch of the Russian Academy of Medical Sciences for fruitful work, great contribution to the development of medical science and health care of the population of Siberia, the Far North and the Far East (2012), Certificate of Merit of the Mayor Tomsk for her contribution to the development of medical science and practical health care, many years of hard work and in connection with the Day of Russian Science (2013), Diploma of the Presidium of the Siberian Branch of the Russian Academy of Sciences (2017), Honorary Diploma of Tomsk Region Administration for her great contribution to the development of scientific research, training of highly qualified specialists, and in connection with the Day of Russian Science (2018).

N.M. Vyalova actively participates in the implementation of 17 grants from leading Russian scientific foundations: RHSF, RFBR, RSF.

Main Publications

1. Geers L.M., Wilffert B., Touw D.J., Ochi T., Loonen A.J.M., Vyalova N.M., Losenkov I.S., Paderina D.Z., Pozhidaev I.V., Simutkin G.G., Bokhan N.A., Ivanova S.A. Influence of eight ABCB1 polymorphisms on antidepressant response in a prospective cohort of treatment-free Russian patients with moderate or severe depression: an explorative psychopharmacological study with naturalistic design // Human Psychopharmacology. 2022. Т. 37. № 3. С. e2826. DOI: 10.1002/hup.2826

2. Ochi T., Loonen A.J.M., Wilffert B., Vyalova N.M., Losenkov I.S., Paderina D.Z., Pozhidaev I.V., Simutkin G.G., Bokhan N.A., Ivanova S.A. Preliminary pharmacogenetic study to explore putative dopaminergic mechanisms of antidepressant action // Journal of Personalized Medicine. 2021. Т. 11. № 8. DOI: 10.3390/jpm11080731

3. Poltavskaya E.G., Fedorenko O.Y., Vyalova N.M., Kornetova E.G., Bokhan N.A., Ivanova S.A., Loonen A.J.M. Genetic polymorphisms of PIP5K2A and course of schizophrenia // BMC Medical Genetics. 2020. Т. 21. № Suppl. 1. С. 171. DOI:10.1186/s12881-020-01107-w

4. Levchenko A., Vyalova N.M., Pozhidaev I.V., Simutkin G.G., Bokhan N.A., Ivanova S.A., Nurgaliev T. NRG1, PIP4K2A, and HTR2C as potential candidate biomarker genes for several clinical subphenotypes of depression and bipolar disorder // Frontiers in genetics. 2020. Т. 11. № MAY. С. 936. DOI: 10.3389/fgene.2020.00936

5. Losenkov I.S., Levchuk L.A., Vyalova N.M., Simutkin G.G., Boiko A.S., Bokhan N.A., Ivanova S.A., Mulder N.J.V., Loonen A.J.M., Wilffert B., Hak E., Schmidt A.F., Bosker F.J. Association between BDNF gene variant rs6265 and the severity of depression in antidepressant treatment-free depressed patients // Frontiers in Psychiatry. 2020. Т. 11. № MAY. С. 38. https://doi.org/10.3389/fpsyt.2020.00038

6. Mikhalitskaya E., Vyalova N., Losenkov I., Simutkin G., Ivanova S., Bokhan N. Assessment of association of polymorphic variants of serotoninergic system genes with depressive symptoms, clinical remission and response to antidepressant therapy // European Neuropsychopharmacology. 2019. Т. 29. С. S230. DOI:10.31363/2313-7053-2019-4-1-95-97

7. Ochi T., Vyalova N.M., Losenkov I.S., Levchuk L.A., Osmanova D.Z., Mikhalitskaya E.V., Loonen A.J.M., Bosker F.J., Simutkin G.G., Bokhan N.A., Wilffert B., Ivanova S.A. Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: a prospective inception cohort study in treatment-free patients // Journal of Affective Disorders. 2019. Т. 259. С. 432-439. DOI: 10.1016/j.jad.2019.08.058

8. Osmanova D.Z., Fedorenko O.Y., Pozhidaev I.V., Boiko A.S., Vyalova N.M., Tiguntsev V.V., Kornetova E.G., Semke A.V., Bokhan N.A., Ivanova S.A., Freidin M.B., Loonen A.J.M., Wilffert B. A pharmacogenetic study of patients with schizophrenia from west Siberia gets insight into dopaminergic mechanisms of antipsychotic-induced hyperprolactinemia // BMC Medical Genetics. 2019. Т. 20. № 1. С. 47. DOI: 10.1186/s12881-019-0773-3

9. Levchenko A., Vyalova N., Pozhidaev I.V., Boiko A.S., Osmanova D.Z., Fedorenko O.Y., Semke A.V., Bokhan N.A., Ivanova S.A., Wilffert B., Loonen A.J.M. No evidence so far of a major role of AKT1 and GSK3B in the pathogenesis of antipsychotic-induced tardive dyskinesia //  Human Psychopharmacology. 2019. Т. 34. № 1. С. e2685. DOI: 10.1002/hup.2685

10. Aftanas L.I., Anisimenko M.S., Berdyugina D.A., Garanin A.Yu., Maximov V.N., Voevoda M.I., Vyalova N.M., Bokhan N.A., Ivanova S.A., Danilenko K.V., Kovalenko S.P. SIRT1 allele frequencies in depressed patients of European descent in Russia // Frontiers in genetics. 2019. Т. 9. № JAN. С. 686. DOI: 10.3389/fgene.2018.00686

11. Ochi T., Loonen A.J.M., Wilffert B., Vyalova N.M., Losenkov I.S., Paderina D.Z., Pozhidaev I.V., Simutkin G.G., Bokhan N.A., Ivanova S.A. Limited associations between 5-HT receptor gene polymorphisms and treatment response in antidepressant treatment-free patients with depression // Frontiers in Pharmacology. 2019. Т. 10. № FEB. С. 1462. DOI: 10.3389/fphar.2019.01462

12. Levchenko A., Losenkov I.S., Vyalova N.M., Simutkin G.G., Bokhan N.A., Ivanova S.A., Wilffert B., Loonen A.J.M. The functional variant rs334558 of GSK3B is associated with remission in patients with depressive disorders // Pharmacogenomics and Personalized Medicine. 2018. Т. 11. С. 121-126. DOI: 10.2147/PGPM.S171423

13. Vyalova N.M., Pozhidaev I.V., Osmanova D.Z., Simutkin G.G., Ivanova S.A., Bokhan N.A. Association of polymorphic variants of the PIP5K2A and HTR2C genes with the effectiveness of antidepressant therapy in patients with a current depressive episode // Neuroscience and Behavioral Physiology. - 2017. - T. 117. - No. 5. - S. 58-61. DOI: 10.17116/jnevro20171175158-61

14. Fedorenko O.Yu., Loonen A.J.M., Vyalova N.M., Boiko А.S., Pozhidaev I.V., Osmanova D.Z., Rakhmazova L.D., Bokhan N.А., Ivanov M.V., Freidin M.B., Ivanova S.А. Hyperprolactinemia and CYP2D6, DRD2 and HTR2C genes polymorphism in patients with schizophrenia // Physiology and pharmacology. - 2017. – V. 21. – N. 1. – P. 25-33. http://phypha.ir/ppj/article-1-1205-en.pdf

15. Levchuk L.A., Vyalova N.M., Simutkin G.G., Bokhan N.A., Ivanova S.A. Neurohumoral markers that predict the efficiency of pharmacologic therapy of depressive disorders // Neurochemical Journal. - 2017. - Т. 11. - № 2. - С. 185-187 DOI: 10.1134/S1819712417020088

16. Losenkov I.S., Vyalova N.M., Simutkin G.G., Bokhan N.A., Ivanova S.A. An association of AKT1 gene polymorphism with antidepressant treatment response // The World Journal of Biological Psychiatry. – 2016. -  Vol. 17, Issue 3. – P. 239-242 (IF 4,15) DOI: 10.3109/15622975.2015.1112921

17. Ivanova S.A., Vyalova N.M., Pozhidaev I.V., Osmanova D.Z., Fedorenko O.Y., Semke A.V., Bokhan N.A., Filipenko M.L., Voronina E.N., Ivanov M.V. CYP1A2 and CYP2D6 gene polymorphisms in schizophrenic patients with neuroleptic drug-induced side effects // Bulletin of Experimental Biology and Medicine. - 2016. - Т. 160. - № 5. - С. 687-690. DOI: 10.1007/s10517-016-3250-4

18. Levchuk L., Vyalova N., Simutkin G., Lebedeva E., Bokhan N., Ivanova S. Brain-derived Neurotrophic Factor in Patients with Affective Disorders // European Psychiatry. 2015. – Vol. 30, Suppl. 1. -  P. 371 (IF 3.439) DOI: 10.1016/S0924-9338(15)30291-1

19. Ivanova S.A., Geers L.M., Al Hadithy A.F., Pechlivanoglou P., Semke A.V., Vyalova N.M., Rudikov E.V., Fedorenko O.Y., Wilffert B., Bokhan N.A., Brouwers J.R., Loonen A.J. Dehydroepiandrosterone sulphate as a putative protective factor against tardive dyskinesia // Prog Neuropsychopharmacol Biol Psychiatry. – 2014. – Vol. 50. – P. 172-177. (IF 4,361) DOI: 10.1016/j.pnpbp.2013.12.015

20. Levchuk L.A., Vyalova N.M., Ivanova S.A., Simutkin G.G., Lebedeva E.V., Bokhan N.A. Serum levels of neurosteroids in patients with affective disorders // Bulletin of Experimental Biology and Medicine. -2015. - Т. 158. - № 5. - С. 638-640. DOI: 10.1007/s10517-015-2825-9

21. Bokhan N.A., Losenkov I.S., Vyalova N.M., Simutkin G.G., Ivanova S.A. Correlation between levels of AKT1/GSK-3β signaling pathway proteins and severity of depressive symptoms // European Neuropsychopharmacology. - 2014. - Т. 24. - № S2. - С. 365 (IF 4,409) DOI10.1016/S0924-977X(14)70583-8

22. Losenkov I.S., Ivanova S.A., Vyalova N.M., Simutkin G.G., Bohan N.A. The content of the AKT1 / GSK-3 signal pathway proteins in peripheral blood mononuclear cells in patients with affective disorders Neurochemical Journal, 2014, Vol. 8, No. 3, pp. 208–213. DOI: 10.1134/S1819712414030106

23. Levchuk L.A., Vyalova N.M., Ivanova S.A., Simutkin G.G., Lebedeva E.V., Bokhan N.A. The content of neurosteroids in the blood serum of patients with affective disorders // Bull Exp Biol Med. – 2015. - 158(5). – P. 638-40. DOI: 10.1007/s10517-015-2825-9 

24. Fedorenko O., Losenkov I., Vyalova N., Rudikov E., Gavrilova V., Boyarko E.,  Semke A., Ivanova S. No association between SGK1 gene rs1743964 polymorphic variant and schizophrenia // European Psychiatry. - 2013. – Vol.  28, Suppl. 1. – P. 1 (IF 3,912) https://doi.org/10.10