Lyudmila P. Smirnova
Ph.D., senior researcher, Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.
Contact Details
e-mail: lрsmirnova@yandex.ru
tel.: + 7 (3822) 72-38-29
Brief Biography
She graduated from the Faculty of Medicine and Biology of Tomsk Medical Institute (SSMU). Since 1985 she has been working at the Oncology Research Institute. She defended her Ph.D. thesis “The role of antioxidant enzymes in the regulation of tumor cell proliferation.” Since 2006 she has been working at Mental Health Research Institute. In 2016, she completed her internship, has a diploma of postgraduate professional education and a certificate of a specialist in the specialty “clinical laboratory diagnostics”. Under the supervision of Smirnova L.P. 4 Ph.D. theses were defended in the specialties “pathological physiology and biochemistry”, currently 2 Ph.D. theses are being carried out under her supervision.
Research Interests
The main scientific interests of Smirnova L.P. lie in the field of research into the involvement of oxidative stress in the pathogenesis of diseases, the study of the catalytic properties of antibodies in patients with mental disorders, and the analysis of blood serum proteomes in various mental disorders. The results of the work are aimed at studying the pathogenesis, searching for biological markers of mental illness and developing the criteria for the early differential diagnosis of mental disorders.
Professional communities
Member of the Russian Mass Spectrometric Society, the Russian Proteomic Society (RHUPO), the European Proteomic Society (European Proteomics Association EuPA), the Russian Biochemical Society (RBO), the Russian Society of Psychiatrists (RSP)
Achievements, Awards, Grants
Laureate of the competition of the Tomsk Region in the field of education and science, healthcare and culture as part of the team of authors, 2009 (for the study “Mechanisms of apoptosis under conditions of oxidative stress in mental and substance use disorders”). Gratitude of the Siberian Branch of the Russian Academy of Medical Sciences for a great contribution to medical science and practical healthcare (2010). Honorary Diploma of the Siberian Branch of the Russian Academy of Medical Sciences for a great contribution to medical science and practical healthcare (2013). Letter of thanks from the Administration of the city of Tomsk to the Day of Russian Science (2015). Labor Veteran (2015). A letter of thanks from the Administration of the Tomsk Region for participating in the organization and holding of the IV U-NOVUS Forum of Young Scientists (2017) and the V U-NOVUS Forum (2018). Gratitude from the Governor of the Tomsk Region on the Day of Russian Science (2019). Honored Veteran of the Siberian Branch of the Russian Academy of Sciences (2021). Laureate of the Tomsk Region Competition Prize in the field of education and science, healthcare and culture (2021).
• Russian Humanitarian Foundation grant no. 08-06-00284a “Development of the hypothesis of allostatic overload in neurotic stress-related disorders” 2008-2010, investigator
• Interdisciplinary integration project of the SB RAS “Medical proteomics and human metabolomics. Chemical and genetic approaches to personalized therapy, no. 90, 2009-2011, investigator
• Integration project of the SB RAS and SB RAMS no. 5 of February 09, 2012 “Medical proteomics: search for markers of socially significant mental disorders (2012-2014)”, principal investigator
• RFBR grant no. 14-34-50683/14 “Prediction of the risk of developing metabolic syndrome in the treatment of patients with schizophrenia with atypical antipsychotics based on the study of the role of endothelial nitric oxide synthase”, 2014, principal investigator
• RSF grant no. 14-15-00480 “Search for key biomarkers of the pathogenesis of socially significant endogenous mental disorders” (2014-2016), investigator
• RSF grant no. 14-35-00023 “Laboratory of Pharmacogenetic Studies of Personalized Therapy for Mental and Neurodegenerative disorders” (2014-2016), investigator
• Program of the Presidium of the Russian Academy of Sciences 1.42 “Development of a technology for predicting the metabolic side effects of antipsychotic therapy in schizophrenia based on the study of the role of endothelial nitric oxide synthase” (2018-2020) responsible investigator
• RSF grant no. 18-15-00053 “Search for peripheral markers associated with impaired brain myelination and disease pathogenesis in schizophrenia” (duration: 2018-2020). Extended 2021-2022, principal investigator.
• RSF grant no. 23-75-00023 “Search for new molecular mechanisms of affective disorders for the purposes of developing the diagnostics and prediction methods using proteomic approaches and neuroimaging” (duration: 2023-2026), supervisor.
Monographs and Chapters in Monographs
1. Smirnova L.P., Ivanova S.A., Semke A.V., Bokhan N.A. Pilot results of proteomic analysis of blood serum of patients with schizophrenia. In the book: Biological markers of schizophrenia: search and clinical application. Boyko A.S., Bokhan N.A., Buneva V.N., Vetlugina T.P., Zozulya S.A., Ivanova S.A., Klyushnik T.P., Kornetova E.G., Losenkov I .S., Oleichik I.V., Semke A.V., Smirnova L.P., Uzbekov M.G., Fedorenko O.Yu. Novosibirsk, 2017, pp. 131-145. https://elibrary.ru/item.asp?id=28982626 (in Russian).
2. Smirnova L.P., Buneva V.N., Kornetova E.G. Catalytic antibodies (abzymes) in patients with schizophrenia: DNA hydrolyzing activity. In the book: Biological markers of schizophrenia: search and clinical application. Boyko A.S., Bokhan N.A., Buneva V.N., Vetlugina T.P., Zozulya S.A., Ivanova S.A., Klyushnik T.P., Kornetova E.G., Losenkov I .S., Oleichik I.V., Semke A.V., Smirnova L.P., Uzbekov M.G., Fedorenko O.Yu. Novosibirsk, 2017, pp. 47-68. https://elibrary.ru/item.asp?id=28973493 (in Russian).
The most significant publications
ORCID 0000-0003-0083-9124
Researcher ID C-9126-2012
1. Seregin, A.A.; Smirnova, L.P.; Dmitrieva, E.M.; Zavialova, M.G.; Simutkin, G.G.; Ivanova, S.A. Differential Expression of Proteins Associated with Bipolar Disorder as Identified Using the PeptideShaker Software. International Journal of Molecular Sciences. 2023; 24(20):15250 https://doi.org/10.3390/ijms242015250 (Scopus, WoS Q1, IF= 6.208)
2. Zavialova M, Kamaeva D, Kazieva L, Skvortsov VS, Smirnova L. 2023. Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients. PeerJ 11:e15584 https://doi.org/10.7717/peerj.15584 Scopus Q1, Web of Science Q2, IF 3.06
3. Epimakhova E.V., Smirnova L.P., Kazantseva D.V., Kamaeva D.A., Ivanova S.A. Different Directions of Effects of Polyclonal IgG Antibodies from Patients with Schizophrenia and Healthy Individuals on Cell Death In Vitro: A Pilot Stady // Curr. Issues Mol. Biol. – 2023 – V45 (4). – P.3168-3179. https://doi.org/10.3390/cimb45040206 (Web of Science, Scopus Q3, Impact Factor 2,976).
4. Dmitrieva E, Smirnova L, Seregin A, Zgoda V, Semke A, Ivanova S. Proteomic profile of serum from patients with schizophrenia spectrum disorders // PeerJ. 2022;10:e13907 (Web of Science Q2, IF 3,06; Scopus Q1, SJR 0,77) https://doi.org/10.7717/peerj.13907
5. Mednova, Irina A., Liudmila P. Smirnova, Alisa R. Vasilieva, Daria V. Kazantseva, Elena V. Epimakhova, Nina M. Krotenko, Arkadiy V. Semke, and Svetlana A. Ivanova. 2022. "Immunoglobulins G of Patients with Schizophrenia Protects from Superoxide: Pilot Results" Journal of Personalized Medicine 12, no. 9: 1449. https://doi.org/10.3390/jpm12091449 (Web of Science Q2, IF 3,508; Scopus Q2, SJR 0,76)
6. Kamaeva DA, Smirnova LP, Vasilieva SN, Kazantseva DV, Vasilieva AR, Ivanova SA. Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein. Int J Mol Sci. 2022 Jul 2;23(13):7397. doi: 10.3390/ijms23137397 (Скопус, WoS Q1, IF = 6.208)
7. Smirnova LP, Yarnykh VL, Parshukova DA, Kornetova EG, Semke AV, Usova AV, Pishchelko AO, Khodanovich MY, Ivanova SA. Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction. Transl Psychiatry 11, 365 (2021). (WOS, Scopus, Q1, IF = 7.097) https://doi.org/10.1038/s41398-021-01475-8
8. Ermakov E.A., Dmitrieva E.M., Parshukova D.A., Kazantseva D.V., Vasilieva A.R., Smirnova L.P. «Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives» Oxidative Medicine and Cellular Longevity Article ID 8881770, 37 pages, 2021, https://doi.org/10.1155/2021/8881770 (Scopus Q1 SJR 1,39; Web of Science Q2 IF 5,076) (0,167).
9. Smirnova L.P., Mednova I.A., Krotenko N.M., Alifirova V.M., Ivanova S.A., "IgG-Dependent Dismutation of Superoxide in Patients with Different Types of Multiple Sclerosis and Healthy Subjects," Oxidative Medicine and Cellular Longevity, vol. 2020, Article ID 8171020, 11 pages, 2020. https://doi.org/10.1155/2020/8171020. (Scopus Q1 SJR 1,39; Web of Science Q2 IF 4,868).
10. Parshukova D.A., Smirnova L.P., Kornetova E.G., Semke A.V., Buneva V.N., and Ivanova S.A. “Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia” // J. Immunol. Res., Volume 2020, Article ID 8986521, 12 pages, 2020. https://doi.org/10.1155/2020/8986521. (IF = 3.327, Scopus SJR Q1, WOS JCR Q3) (0,167).
11. Smirnova L, Seregin A, Boksha I, Dmitrieva E, Simutkin G, Kornetova E, Savushkina O, Letova A, Bokhan N, Ivanova S, Zgoda V. The difference in serum proteomes in schizophrenia and bipolar disorder. // BMC Genomics – 2019 Jul 11;20 (Suppl 7) :535. doi: 10.1186/s12864-019-5848-1 (WoS IF 3,5, Scopus IF 1,83; Q1)
12. Fattakhov N., Smirnova L., Atochin D., Parshukova D., Skuratovskaia D., Painter Q., Zatolokin P., Semke A., Litvinova L., Ivanova S. Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients International Journal of Obesity 2018 https://doi.org/10.1038/s41366-018-0124-z (Scopus SJR – 2,65, Web of Science IF - 5.151; Q1)
13. Ermakov E.A., Smirnova L.P., Bokhan N.A., Semke A.V., Ivanova S.A., Buneva V.N., Nevinsky G.A. Catalase activity of IgG antibodies from the sera of healthy donors and patients with schizophrenia. // PLoS One. 2017 Sep 25;12(9) (WoS IF2,806): https://doi.org/10.1371/journal.pone.0183867
14. Ermakov EA, Smirnova LP, Parkhomenko TA, Dmitrenok PS, Krotenko NM, Fattakhov NS, Bokhan NA, Semke AV, Ivanova SA, Buneva VN, Nevinsky GA. DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia. Open Biol. 2015 Sep;5(9):150064. (IF 5,303) DOI: 10.1098/rsob.150064
15. Smirnova L.P., Parshukova D.A., Borodyuk Yu.N., Kornetova E.G., Tkacheva G.D., Seregin A.A., Burdovitsina T.G., Semke A.V. Changes in the lipid spectrum and ECG in patients with paranoid schizophrenia during therapy with atypical antipsychotics. S.S. Korsakov Journal of Neurology and Psychiatry. No. 3, 2015, P. 38-42 https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2015/3/downloads (in Russian).
16. Smirnova L.P., Ivanova S.A., Krotenko N.M., Levchuk L.A., Gutkevich E.V., Semke V.Ya. Characteristics of the antioxidant status in neurotic disorders // Journal of Human Physiology, 2012, vol. 38, no. 5, p. 106–111 https://elibrary.ru/item.asp?id=17928373 (in Russian).
17. Smirnova L.P., Krotenko N.V., Grishko E.V., Krotenko N.M., Alifirova V.M., Ivanova S.A. The state of the antioxidant system in patients with multiple sclerosis in the dynamics of therapy. Biomedical Chemistry. - 2011. V.57. No. 6. pp.661–670. https://elibrary.ru/item.asp?id=17099469
18. Smirnova L.P., Kondakova I.V., Rogozin E.A. Antioxidant enzyme activities in the cells of solid and ascitic Ehrlich carcinomas // Experimental Oncology 2003 (March) V.25, no. 1. p. 60-63 https://elibrary.ru/item.asp?id=14931225
Patents
1. Dmitrieva E.M., Smirnova L.P., Seregin A.A., Zgoda V.G., Semke A.V., Ivanova S.A. Patent of the Russian Federation no. 2788149 C1 / Proteins DCLK1 and RIPK1 biomarkers of simple schizophrenia. Published on 17.01.2023. Application no. 2021133491 of 18.11.2021.
2. Smirnova L.P., Kornetova E.G. Loginova L.V., Ivanova S.A., Darmaeva B-Kh.V., Semke A.V., Bokhan N.A. Patent of the Russian Federation no. 2578957 Laboratory method for diagnosing leading negative symptoms in patients with schizophrenia. Published on 01.03.2016 Bull. no. 9.
3. Smirnova L.P., Loginova L.V., Ivanova S.A., Dmitrieva E.M. Seregin A.A. Mikilev F.F. Semke A.V., Bokhan N.A. RF patent no. 2569741. Laboratory method for diagnosing schizotypal disorder. Published on 27.11.2015 Bull. no. 33
4. Smirnova L.P., Loginova L.V., Ivanova S.A., Koval V.V., Simutkin G.G. Patent of the Russian Federation no. 2558056. Laboratory method for diagnosing bipolar disorder. Published on 27.07.2015 Bull. no. 21, 2015
5. Smirnova L.P., Ivanova S.A., Loginova L.V., Koval V.V., Kornetova E.G., Semke A.V. Patent of the Russian Federation no. 2522236. Laboratory method for the differential diagnosis of endogenous psychoses. Published on May 15, 2014 Bull. no. 19, 2014
6. Smirnova L.P., Kondakova I.V., Borunov E.V. RF patent no. 2272074 Method for determining the activity of superoxide dismutase / Publ. 03/20/2006, Bull. no. 8.
7. Smirnova L.P., Kamaeva D.A., Yarnykh V.L., Mednova I.A., Seregin A.A., Vasilieva A.R., Kazantseva D.V., Krotenko N.M., Semke A.V., Ivanova S.A. Certificate on registration of database no. 2021622881 “Parameters of the quantitative MRI, catalytic activities of G class immunoglobulins and clinical characteristics of schizophrenic patients at the stage of remission” of 10.12.2021.
Training of highly qualified personnel:
1) Post-graduate student of the Mental Health Research Institute of the Tomsk NRMC Loginova L.V. Topic of the thesis: “Relationship of blood serum proteins identified by proteomic analysis with the features of the pathogenesis of psychogenic and endogenous mental disorders”. The date of defense is November 30, 2018.
2) Competitor of the Mental Health Research Institute of the Tomsk NRMC Parshukova D.A. Topic of the thesis: “Abzymes hydrolyzing myelin basic protein in patients with schizophrenia”. The date of defense is June 25, 2019.
3) Competitor of the ICBBM SB RAS, Novosibirsk, The Laboratory of Reparation of Enzymes. Ermakov E.A. Topic: “Natural catalytic immunoglobulin class G in schizophrenia”. The date of defense is December 25, 2020.
4) Competitor of the Mental Health Research Institute of the Tomsk NRMC Dmitrieva E.M. Thesis: “Comparative proteomic analysis of blood serum of patients with schizophrenia spectrum disorders”. Defense date December 17, 2021.