Lyudmila Levchuk
Doctor of Biological Sciences, scientific secretary, senior researcher of the Laboratory of Molecular Genetics and Biochemistry, Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.
Contacts
e-mail: levchukniipz@mail.ru
tel.: 8 (3822) 72-31-98
РИНЦ: AuthorID: 181913
ResearcherID Web of Science: R-8201-2016
Scopus (Author ID): 55386990200
ORCID: 0000-0003-1982-8492
Brief Biography
She successfully completed the Master's degree from Tomsk State University (Department of Cytology and Genetics) in 2005. Lyudmila has been working on the staff of the Mental Health Research Institute since 2005. She defended her Ph.D. thesis “Hormonal status, genetic polymorphism, and motivation-need traits in mental adaptation and maladaptation” in the specialties “Physiology” and “Pathological Physiology”. In December 2024, Lyudmila received the academic degree “Doctor of Biological Sciences”, having defended her dissertation on the topic “Markers of neuroplasticity, neurodegeneration and immunoinflammation in affective disorders: pathobiological patterns and predictive potential” (specialty “Psychiatry and Narcology” (biological sciences).
Research Interests
The main works of Levchuk L.A. are associated with the study of neurohumoral regulation and molecular genetics of mental disorders, incl. mood disorders.
Achievements, Awards, and Grants
Laureate of the Second International Competition of Junior Researchers and Specialists 'Peptide preparations - Agents of the 21st Century' of the Charitable Foundation of Young Hippocrates (2010)
Laureate of the Tomsk Region Prize in the field of education, science, health, and culture (2010, 2016)
The ECNP CDE grant for participation in the work of the Congress of the European College of Neuropsychopharmacology (2017, 2019, 2020)
Certificate of participation in the program of the pilot project “Schools of Key Researchers of the Tomsk Region” (2018)
Certificate and honorary badge “The Future of the Tomsk Region” for winning the competition of project initiatives of the Administration of the Tomsk Region in the thematic direction “Personalized medicine, high-tech healthcare and health-saving technologies” (2018)
Certificate of professional development on the program 'Management of strategic organization development' (2020)
Certificate of professional development on the program "Ecosystem Foundations in the Development of Basic Processes of a Scientific Consortium" (2021)
Medal of the Governor of Tomsk Region "For Achievements" (2025)
Levchuk L.A. participated in 23 research projects under support of domestic scientific foundations (Russian Science Foundation, President of the Russian Federation, Russian Foundation of Basic Research, Russian Humanitarian Scientific Foundation, and Federal Target Programs of Russia).
Monographs
1. Bokhan N.A., Ivanova S.A., Levchuk L.A. Serotonin system in the modulation of depressive and aggressive behavior. Tomsk, Publishing House Ivan Fedorov, 2013. 102 p.
2. Ivanova S.A., Losenkov I.S., Levchuk L.A., Boiko, A.S., Vyalova, N.M., Simutkin, G.G., Bokhan, N.A. Depressive disorders: hypotheses of pathogenesis and potential biological markers. Novosibirsk, Publishing House of the Siberian Branch of the Russian Academy of Sciences, 2018. 199 p. / ISBN 978-5-7692-1590-2
3. Modern psychocardiology / Lebedeva E.V., Nonka T.G., Repin A.N., Shishneva E.V., Schastnyy E.D., Simutkin G.G., Levchuk L.A. / N.A. Bokhan, R.S. Karpov, eds. Tomsk: IntegratedaQW2 Casework, Ltd, 2019. 160 p. ISBN 978-5-6041467-1-2
Results of the intellectual property
1. Ivanova S.A., Semke A.V., Rakitina N.M., Kornetova E.G., Fedorenko O.Yu., Ryadovaya L.A., Gutkevich E.V. Method of prognosis of the efficiency of the treatment of residual schizophrenia with atypical neuroleptics (patent for invention no. 2319155, 2008)
2. Ivanova S.A., Gutkevich E.V., Semke V.Ya., Vyalova N.M., Ryadovaya L.A., Epanchintseva E.M., Perchatkina O.E. Method of prognosis of the course of neurotic disorders (patent of invention no. 2356059, 2009)
3. Levchuk L.A., Semke V.Ya., Ivanova S.A., Perchatkina O.E., Gutkevich E.V. Method of prognosis of the course of borderline mental disorders (patent for invention no. 2455646, 2011)
4. Levchuk L.A., Ivanova S.A., Semke V.Ya., Axenov M.M. Method of prognosis of the efficiency of Ladasten therapy in organic asthenic disorders (patent for invention no. 2459208, 2011)
5. Levchuk L.A., Ivanova S.A., Simutkin G.G., Lebedeva E.V., Vyalova N.M., Losenkov I.S., Bokhan N.A. Method of prognosis of the efficiency of the depressive episode therapy (patent for invention no. 2530635, 2014)
6. Vyalova N.M., Levchuk L.A., Savochkina D.N., Menyavtseva T.A., Vasilieva S.N., Simutkin G.G., Schastnyy E.D., Ivanova S.A., Bokhan N.A. Method of prognosis of comorbid anxiety disorder in patients with recurrent depressive disorder (patent of invention no. 2644636, 2018)
7. Koroleva E.S., Alifirova V.M., Kazakov S.D., Levchuk L.A., Brazovskaya N.G., Ivanova S.A. Clinical, paraclinical and neurobiological characteristics of patients with ischemic stroke in stages of medical rehabilitation between the 1st and 90th days (database certificate no. 2020622069, 2020)
8. Levchuk L.A., Roshchina O.V., Simutkin G.G., Boyko A.S., Bokhan N.A., Ivanova S.A. Clinical, dynamic and biological parameters in patients with alcohol dependence syndrome, affective disorders, and their comorbidity during psychopharmacotherapy (database certificate no. 2020622477, 2020)
9. Koroleva E.S., Alifirova V.M., Kazakov S.D., Brazovskaya N.G., Ivanova S.A., Levchuk L.A. A method to predict the probability of a fatal outcome in a 14-day period of acute ischemic cerebral stroke (patent for invention no. 2748685, 2021)
10. Koroleva E.S., Alifirova V.M., Kazakov S.D., Brazovskaya N.G., Ivanova S.A., Levchuk L.A. A method to predict the recovery of sensorimotor functions in patients with acute ischemic stroke (patent for invention no. 2753140, 2021)
11. Levchuk L.A., Simutkin G.G., Roshchina O.V., Ivanova S.A., Bokhan N.A. A method to predict the comorbid course of an affective disorder and alcohol dependence based on the determination of blood serum proteins (patent for invention no. 2767699, 2022)
12. Levchuk L.A., Roshchina O.V., Simutkin G.G., Ivanova S.A., Bokhan N.A. Method for predicting the course of affective disorder of bipolar and unipolar depressive type based on the determination of blood serum proteins (patent for invention no. 2835348, 2025)
13. Kucherova K.S., Koroleva E.S., Alifirova V.M., Levchuk L.A., Boyko A.S., Ivanova S.A. Database of biological markers of angiogenesis and neuroinflammation, clinical and instrumental data of patients with acute ischemic stroke (database certificate no. 2025621616, 2025).
Main Publications
1. Ryadovaya L.A., Gutkevich Y.V., Ivanova S.A., Semke V.Y., Yepanchintseva Y.M. Hormonal parameters and genetic polymorphism in disorders related to norm and neurotic stress. Bulletin of Siberian Medicine. 2008;7(3):19-23. (In Russ.) https://doi.org/10.20538/1682-0363-2008-3-19-23
2. Hadithy A.F.Y. Al, Ivanova S.A., Pechlivanoglou P., Semke A., Fedorenko O., Kornetova E., Ryadovaya (Levchuk) L., Brouwers J.R.B.J., Wilffert B., Bruggeman R., Loonen A.J.M. Tardive dyskinesia and DRD3, HTR2A, and HTR2C gene polymorphisms in Russian psychiatric inpatients from Siberia // Progress in Neuro-Psychopharmacology & Biological Psychiatry.- 2009.- N.33.- P. 475–481. DOI: 10.1016/j.pnpbp.2009.01.010
3. Al Hadithy A.F., Ivanova S., Pechlivanoglou P., Wilffert B., Semke A., Fedorenko O., Kornetova E., Ryadovaya (Levchuk) L., Brouwers J.R., Loonen A.J. Missense polymorphisms in three oxidative stress enzymes (GSTP1, SOD2, and GPX1) and dyskinesias in Russian psychiatric patients from Siberia // Hum Psychopharmacol. - 2010. - 25 (1). - P.84-91. DOI: 10.1002/hup.1087
4. Smirnova L.P., Ivanova S.A., Krotenko N.M., Levchuk L.A., Gutkevich E.V., Semke V.Y. Study of the indices of antioxidant defense in mental maladaptation // HUMAN PHYSIOLOGY. – 2012. – Vol. 38, N 5. – P.543-547. DOI: 10.1134/S0362119712040135
5. Levchuk L.A., Ivanova S.A., Semke V.Y. Effects of neuroprotector cortexin on the dynamics of neuroendocrine system parameters in patients with organic emotionally labile (asthenic) disorders // Bull Exp Biol Med. – 2013. – Vol. 155, No. 1. – рр. 75-77. doi: 10.1007/s10517-013-2083-7.
6. Levchuk, LA, Vyalova, NM, Ivanova, SA, Simutkin, GG, Lebedeva, EV, Bokhan, NA. Serum levels of neurosteroids in patients with affective disorders // Bull Exp Biol Med. – 2015. – Vol. 158(5). – pp. 638-640. doi: 10.1007/s10517-015-2825-9.
7. Levchuk L., Vyalova N., Simutkin G., Bokhan N., Ivanova S. Neurohumoral markers that predict the efficiency of pharmaceutical therapy of depressive disorders // Neurochemical Journal. - 2017. - Vol. 11, No. 2. - pp. 185–187. https://doi.org/10.1134/S1819712417020088
8. Losenkov, I. S., Boiko A. S., Levchuk L. A., Simutkin G. G., Bokhan N. A. and Ivanova S.A. Blood serum glutamate in patients with depressive disorders as a potential peripheral marker of the prognosis of the effectiveness of therapy // Neurochemical Journal. – 2018. – Vol. 12, № 4. – P. 366–372. https://doi.org/10.1134/S1819712418030066
9. Epimakhova E.V., Levchuk L.A., Fedorenko O.Yu., Ivanova S.A., Starostenko N.A., Lizura I.V., Bokhan N.A. Stress hormones in men whose professional activities are office-based or of extreme emergency nature // Yakut Medical Journal. - 2019. - No2 (66). - P. 20-23. DOI 10.25789/YMJ.2019.66.05
10. Ochi T., Vyalova N.M., Losenkov I.S., Levchuk L.A., Osmanova D.Z., Mikhalitskaya E.V., Loonen A.J.M., Bosker F.J., Simutkin G.G., Bokhan N.A., Wilffert B., Ivanova S.A. Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients // Journal of Affective Disorders. – 2019. – Vol. 259. – P. 432–439. doi: 10.1016/j.jad.2019.08.058.
11. Koroleva E.S., Alifirova V.M., Brazovskaya N.G., Plotnikov D.M., Levchuk L.A., Boyko A.S., Zapekin S.G., Semenenko A.S., Kataeva N.G., Ivanova S.A. Clinical and laboratory evaluation of the effectiveness of early rehabilitation of stroke patients using assistive robotic tools. Bulletin of Siberian Medicine. 2019;18(4):55-62. (In Russ.) https://doi.org/10.20538/1682-0363-2019-4-55-62
12. Losenkov I.S., Mulder N.J.V., Levchuk L.A., Vyalova N.M., Loonen A.J.M., Bosker F.J., Simutkin G.G., Boiko A.S., Bokhan N.A., Wilffert B., Hak E., Schmidt A.F., Ivanova S.A. Association Between BDNF Gene Variant Rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients // Front. Psychiatry. – 2020. – Vol.11. doi: 10.3389/fpsyt.2020.00038
13. Levchuk L.A., Meeder EMG, Roshchina OV, Loonen AJM, Boiko ASA, Mikhalitskaya EM, Epimakhova EM, Losenkov ISS, Simutkin GM, Bokhan AA, Schellekens AFAA, Ivanova ASA Exploring Brain-derived neurotrophic factor and cell adhesion molecules as biomarkers for transdiagnostic symptoms of anhedonia in alcohol use disorder and comorbid depression. Front Psychiatry. – 2020. – Vol. 11. – P. 296. doi: 10.3389/fpsyt.2020.00296
14. Koroleva ES, Brazovskaya NG, Levchuk LA, Kazakov SD, Romadina NY, Alifirova VM. Evaluation of neuron-specific enolase and BDNF levels at the rehabilitation stages in acute and early recovery periods of ischemic stroke. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2020;120(8-2):30-36. (In Russ.) https://doi.org/10.17116/jnevro202012008230
15. Levchuk L.A., Roshchina O.V., Simutkin G.G., Bokhan N.A., Ivanova S.A. Peripheral Markers of Nervous Tissue Damage in Addictive and Affective Disorders // Neurochemical Journal. 2021. – Vol. 15, No. 1. – P. 85–89. DOI: 10.1134/S1819712421010074
16. Koroleva E.S., Brazovskaya N.G., Levchuk L.A., Kazakov S.D., Romadina N.Yu., Alifirova V.M. Assessment of neuron-specific enolase and brain-derived neurotrophic factor levels in rehabilitation stages in early and late recovery periods from ischemic stroke // Neuroscience and Behavioral Physiology. 2021. – Vol. 51. – P. 570–576. https://doi.org/10.1007/s11055-021-01107-0
17. Roshchina O.V., Levchuk L.A., Boiko A.S., Mikhalitskaya E.V., Epimakhova E.V., Losenkov I.S., Simutkin G.G., Loonen A.J.M., Bokhan N.A., Ivanova S.A. Beta-Endorphin and oxytocin in patients with alcohol use disorder and comorbid depression // Journal of Clinical Medicine. 2021. – Vol. 23, No. 10. doi: 10.29001/2073-8552-2018-33-3-86-92
18. Bokhan N.A., Roshchina O.V., Simutkin G.G., Levchuk L.A., Ivanova S.A. Anhedonia as target symptom in personalized therapy of patients with mood disorders and alcohol use disorder comorbidity. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2022;122(3):92‑97. (In Russ.). https://doi.org/10.17116/jnevro202212203192
19. Mednova IA, Levchuk LA, Boiko AS, Roschina OV, Simutkin GG, Bokhan NA, Loonen AJM, Ivanova SA. Cytokine level in patients with mood disorder, alcohol use disorder and their comorbidity. World J Biol Psychiatry. 2023 Mar;24(3):243-253. doi: 10.1080/15622975.2022.2095439. https://pubmed.ncbi.nlm.nih.gov/35818961/
20. Galkin SA, Levchuk LA, Simutkin GG, Ivanova SA, Bokhan NA. Coherence of the electroencephalogram and peripheral markers of nerve tissue damage in depressive disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(3):82‑87. (In Russ.) https://doi.org/10.17116/jnevro202312303182
21. Levchuk L.A., Bokhan N.A., Ivanova S.A. Neurospecific Proteins as Transdiagnostic Markers of Affective Disorders // Neurochemical Journal, 2023, Vol. 17, No. 1, pp. 25–29. DOI: 10.1134/S1819712423010117
22. Levchuk LA, Roschina OV, Mikhalitskaya EV, Epimakhova EV, Simutkin GG, Bokhan NA, Ivanova SA. Serum Levels of S100B Protein and Myelin Basic Protein as a Potential Biomarkers of Recurrent Depressive Disorders. J Pers Med. 2023 Sep 21;13(9):1423. doi: 10.3390/jpm13091423. https://pubmed.ncbi.nlm.nih.gov/37763190/
23. Mikhalitskaya EV, Vyalova NM, Ermakov EA, Levchuk LA, Simutkin GG, Bokhan NA, Ivanova SA. Association of Single Nucleotide Polymorphisms of Cytokine Genes with Depression, Schizophrenia and Bipolar Disorder. Genes (Basel). 2023 Jul 17;14(7):1460. doi: 10.3390/genes14071460. https://pubmed.ncbi.nlm.nih.gov/37510364/
24. Roschina O.V., Levchuk L.A., Simutkin G.G., Ivanova S.A., Bokhan N.A. Relationship of Neurospecific Serum Proteins with Clinical Features in Depressive Episode and Recurrent Depressive Disorder. Psychiatry (Moscow) (Psikhiatriya). 2023;21(4):42-48. (In Russ.) https://doi.org/10.30629/2618-6667-2023-21-4-42-48
25. S. A. Galkin, L. A. Levchuk, G. G. Simutkin, S. A. Ivanova & N. A. Bokhan. Electroencephalogram Coherence and Peripheral Markers of Nervous Tissue Damage in Depressive Disorders. Neurosci Behav Physi 53, 1355–1359 (2023). https://doi.org/10.1007/s11055-023-01525-2
26. Chernonosov AA, Mednova IA, Levchuk LA, Mazurenko EO, Roschina OV, Simutkin GG, Bokhan NA, Koval VV, Ivanova SA. Untargeted Plasma Metabolomic Profiling in Patients with Depressive Disorders: A Preliminary Study. Metabolites. 2024 Feb 6;14(2):110. doi: 10.3390/metabo14020110. PMID: 38393002; https://pubmed.ncbi.nlm.nih.gov/38393002/
27. Kamenskikh EM, Alifirova VM, Pashkovskaya DV, Titova MA, Koroleva ES, Levchuk LA, Ivanova SA. Serum neurofilament light chains in assessing the course of multiple sclerosis. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2024;124(1):89‑93. (In Russ.) https://doi.org/10.17116/jnevro202412401189
28. Nikitina MA, Bragina EYu, Nazarenko MS, Levchuk LA, Ivanova SA, Boiko AS, Gomboeva DE, Koroleva ES, Alifirova VM. The relationship between the rs6265 polymorphism of the BDNF gene and the level of serum neurotrophic factor in patients with Parkinson’s disease. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. 2024;124(1):114‑120. (In Russ.) https://doi.org/10.17116/jnevro2024124011114
29. Levchuk L.A., Biktimirov D.R., Gutkevich E.V., Roshchina O.V., Vasilieva S.N., Kazennykh T.V., Perchatkina O.E., Aksenov M.M. Humoral factors of anabolic and catabolic balance in women with depressive disorders. Siberian Herald of Psychiatry and Addiction Psychiatry. 2024; 1 (122): 18-26. https://doi.org/10.26617/1810-3111-2024-1(122)-18-26
30. Nikitina MA, Bragina EYu, Ivanova SA, Boyko AS, Levchuk LA, Nazarenko MS, Alifirova VM. Association of inflammation and chronic fatigue syndrome in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9):79‑87. (In Russ.) https://doi.org/10.17116/jnevro202412409179
31. Ryazantseva UV, Boiko AS, Levchuk LA, et al. Growth factors PDGF-AA, PDGF-BB and BDNF as potential differentiating biomarkers of unipolar and bipolar depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(9):104‑108. (In Russ.) https://doi.org/10.17116/jnevro2024124091104
32. Galkin SA, Levchuk LA, Ivanova SA, Bokhan NA. A pilot study of associations of markers of glial and neuronal degeneration with executive functions in alcohol use disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(10):74‑79. (In Russ.) https://doi.org/10.17116/jnevro202412410174
33. Nikitina MA, Bragina EYu, Nazarenko MS, Ivanova SA, Boyko AS, Levchuk LA, Alifirova VM. Neuroinflammatory and neurodegenerative aspects of Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3):102‑111. (In Russ.) https://doi.org/10.17116/jnevro2025125031102
34. Nikitina, M.A., Bragina, E.Y., Ivanova (1,2), S.A. A. S. Boyko (1), L. A. Levchuk (1), M. S. Nazarenko, V. M. Alifirova Association between Inflammation and Chronic Fatigue Syndrome in Parkinson’s Disease. Neurosci Behav Physi 55, 531–539 (2025). https://doi.org/10.1007/s11055-025-01795-y
35. Ryazantseva U.V., Boiko A.S., Levchuk L.A., Vasileva S.N., Simutkin G.G., Ivanova S.A., Roschina O.V., Bokhan N.A. Growth Factors PDGF-AA, PDGF-BB, and BDNF as Potential Differential Biomarkers of Unipolar and Bipolar Depression. Neurosci Behav Physi 55, 544–548 (2025). https://doi.org/10.1007/s11055-025-01797-w