Personalities

Losenkov Innokentiy

Losenkov Innokentiy, MD, PhD, researcher in the department of affective disorders of Mental health research institute of Tomsk national research medical center of the Russian academy of sciences.

Contact information

e-mail: innokenty86@mail.ru
tel.: (3822) 72-38-32

ResearcherID: N-2144-2016

Scopus Author ID: 56300031600

ORCID: 0000-0001-7458-2179

e-library AuthorID: 623495

Brief biography

In 2009 graduated with honors from the Medico-biological faculty of the Siberian State Medical University with a specialty in medical biochemistry. In 2010 graduated from an internship at the Siberian State Medical University with a specialty in clinical laboratory diagnostics. Has been working at the Mental health research institute since 2011 as a junior researcher, since 2017 as a researcher in the department of affective disorders. In 2015 he defended his PhD thesis on the topic "Clinical and pathophysiological features of the functioning of glycogen synthase kinase-3β in affective disorders (clinical experimental study)" in the specialties "psychiatry" and "pathological physiology". 

Fields of interest

The role of intracellular proteins in the pathogenesis of affective disorders, the cytoprotective properties of lithium salts, the search for biomarkers of depression.

Awards

1. The winner of the scientific works competition of the XIV Russian school of young psychiatrists "Suzdal-2019" (Suzdal, 2019).

2. Laureate of the Prize of the Legislative Duma of the Tomsk region for young scientists and young talents (Tomsk, 2018).

3. The winner of the scientific works competition of the XIII Russian School of Young Psychiatrists "Suzdal-2017" (Suzdal, 2017).

4. The winner of the scientific works competition of the Russian School of Young Scientists and Specialists in the Field of Mental Health "Psychiatry yesterday, today, tomorrow" (Kostroma, 2014)

Grants

1. Russian Science Foundation grant № 17-75-20045 "Effect of organic lithium salts on cells and blood plasma of patients with affective spectrum disorders and dependence syndrome" (2017 - 2020).

2. Russian Science Foundation grant № 19-15-00023 "Clinical features and the search for potential biomarkers of the comorbidity of alcoholism and affective disorders" (2019 - 2021).

3. Russian Foundation for Basic Research grant № 17-29-02205 "Development of a molecular-genetic panel of depressive disorders based on polymorphisms of the genes of neuronal kinases, neurotrophic proteins and genes of the serotonergic system" (2017 - 2021).

4. Russian Foundation for Basic Research grant № 14-04-01157 А “The search for biomarkers of depressive and mood disorders” (2014-2017).

5. Russian Science Foundation grant № 14-15-00480 "The search for biomarkers of socially significant endogenous mental disorders" (2014-2016).

6. Russian Foundation for Basic Research grant № 14-04-31925 «The role of impairment of neuroplasticity in the pathogenesis of affective disorders»

7. Russian Foundation for Basic Research grant № 12-04-33072 «The pathogenesis of movement antipsychotic induced disorders in patients with endogenous mental disorders: the role of pharmacogenetic factors»

8. Russian Foundation for Basic Research grant № 12-04-31268 « Role of glycogen synthase kinase 3 beta in pathogenesis of depressive and bipolar affective disorders» (2012 - 2013).

Total publications – 49, including:

• 4 monographs.

• 4 patents.

• 4 medical technologies.

• 37 articles: 27 - in journals indexed by Web of Science Core Collection or Scopus; including 23 in the first quartile (Q1) by the JCR Science Edition impact factor.

The most significant articles

1. Ochi T., Vyalova N.M., Losenkov I.S., Paderina D.Z., Pozhidaev I.V., Loonen A.J.M., Simutkin G.G., Bokhan N.A., Wilffert B., Ivanova S.A. Preliminary Pharmacogenetic Study to Explore Putative Dopaminergic Mechanisms of Antidepressant Action // Journal of Personalized Medicine. – 2021. – Vol. 11, № 8. doi: 10.29001/2073-8552-2018-33-3-86-92

2. Roschina O.V., Levchuk L.A., Boiko A.S., Michalitskaya E.V., Epimakhova E.V., Losenkov I.S., Simutkin G.G., Loonen A.J.M., Bokhan N.A., Ivanova S.A. Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression // Journal of Clinical Medicine. – 2021. – Vol. 23, № 10. doi: 10.29001/2073-8552-2018-33-3-86-92

3. Ochi T., Vyalova N.M., Losenkov I.S., Paderina D.Z., Pozhidaev I.V., Loonen A.J.M., Simutkin G.G., Bokhan N.A., Wilffert B., Ivanova S.A. Influence of eight ABCB1 polymorphisms on antidepressant response in a prospective cohort of treatment‐free Russian patients with moderate or severe depression: An explorative psychopharmacological study with naturalistic design // Human Psychopharmacology Clinical and Experimental. – 2021. – Vol. 11, № 8. doi: 10.1002/hup.2826

4. Levchuk L.A., E.M.G. Meeder, O.V. Roschina, A.J.M. Loonen, A.S. Boiko, E.V. Michalitsakay, E.V. Epimakhova, I.S. Losenkov, G.G. Simutkin, N.A. Bokhan, A.A.F. Schellekens, S.A. Ivanova. Exploring Brain Derived Neurotrophic Factor and Cell Adhesion Molecules as Biomarkers for the Transdiagnostic Symptom Anhedonia in Alcohol Use Disorder and Comorbid Depression // Frontiers in Psychiatry. – 2020. – Vol. 11. doi.org: 10.3389/fpsyt.2020.00296

5. Losenkov I.S., Plotnikov E.V., Epimakhova E.V., Bokhan N.A. Lithium in the psychopharmacology of affective disorders and mechanisms of its effects on cellular physiology. Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova. – 2020. – Vol.120, № 11. – P. 108–115. doi.org: 10.17116/jnevro2020120111108.

6. Losenkov I.S., Mulder N.J.V., Levchuk L.A., Vyalova N.M., Loonen A.J.M., Bosker F.J., Simutkin G.G., Boiko A.S., Bokhan N.A., Wilffert B., Hak E., Schmidt A.F., Ivanova S.A. Association Between BDNF Gene Variant rs6265 and the Severity of Depression in Antidepressant Treatment-Free Depressed Patients / // Frontiers in Psychiatry. – 2019. – Vol. 11. doi: 10.3389/fpsyt.2020.00038

7. Ochi T., Vyalova N.M., Losenkov I.S., Paderina D.Z., Pozhidaev I.V., Loonen A.J.M., Simutkin G.G., Bokhan N.A., Ivanova S.A. Wilffert B. Limited Associations Between 5-HT Receptor Gene Polymorphisms and Treatment Response in Antidepressant Treatment-Free Patients with Depression // Frontiers in Pharmacology. – 2019. – Vol. 10. doi: 10.3389/fphar.2019.01462.

8. Ochi T., Vyalova N.M., Losenkov I.S., Levchuk L.A., Osmanova D.Z., Mikhalitskaya E.V., Loonen A.J.M., Bosker F.J., Simutkin G.G, Bokhan N.A., Wilffert B., Ivanova S.A. Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients // Journal of Affective Disorders. – 2019. – Vol. 259. – P. 432–439. doi: 10.1016/j.jad.2019.08.058.

9. Plotnikov E., Losenkov I., Epimakhova E., Bohan N. Protective effects of pyruvic acid salt against lithium toxicity and oxidative damage in human blood mononuclear cells // Advanced Pharmaceutical Bulletin. – 2019. – Vol. 9. № 2. – P. 302-306. doi: 10.15171/apb.2019.035

10. Plotnikov E., Prokopieva V., Yarygina E., Losenkov I. Lithium ascorbate as a protector of human blood biomolecules under ethanol impact // National Journal of Physiology, Pharmacy and Pharmacology. – 2018. – Vol. 8, № 1. – P. 82–86.

11. Losenkov I.S., Boiko A.S., Levchuk L.A., Simutkin G.G, Bokhan N.A., Ivanova S.A. Blood-Serum Glutamate in Patients with Depressive Disorders as a Potential Peripheral Marker of the Prognosis of the Effectiveness of Therapy // Neurochemical Journal. – 2018. – Vol. 12, № 4. – P. 366–372. doi: 10.1134/S1819712418030066

12. Levchenko A., Losenkov I.S., Vyalova N.M., Simutkin G.G., Bokhan N.A., Wilffert B., Loonen A.J., Ivanova S.A. The functional variant rs334558 of GSK3B is associated with remission in patients with depressive disorders // Pharmgenomics Pers Med. – 2018. – Vol. 11. doi: 10.2147/PGPM.S171423.

13. Losenkov I.S., Vyalova N.M., Simutkin G.G., Bokhan N.A., Ivanova S.A. An association of AKT1 gene polymorphism with antidepressant treatment response // The World journal of biological psychiatry. – 2016. – Vol. 17, № 3. – P. 239—242. doi: 10.3109/15622975.2015.1112921

14. Losenkov I.S., Ivanova S.A., Vyalova N.A. Simutkin G.G., Bokhan N.A. Proteins of the Akt1/GSK-3 beta signaling pathway in peripheral blood mononuclear cells of patients with affective disorders // Neurochemical Journal. – 2014. – Vol.8, № 3. – P. 240–245. doi: 10.1134/S1819712414030106