Personalities

Lobacheva Olga A.

MD, lead researcher of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology of Mental Health Research Institute of Tomsk NRMC.

Contacts

e-mail: oalobacheva@mail.ru tel.: +7 (3822) 72-44-15 fax: +7 (3822) 72-44-25

Vita

Olga Lobacheva graduated from the Medico-Biological Faculty of Tomsk Medical Institute in 1986 (specialty “Biochemistry”).

Since 1986 she works at Mental Health Research Institute.

In 1994 Lobacheva O.A. defended her PhD thesis “State of the immunity system in hard-to-cur schizophrenic patients under complex psychopharmacotherapy with inclusion of timogen” and in 2011 – MD thesis “Clinical-immunological patterns of adaptation of schizophrenic pateints” (specialties: 14.01.06 – “psychiatry”; 14.03.03 – “pathological physiology”).

Since 1994 – researcher of the Laboratory of Immunobiology

Since 2000 – senior researcher of the Laboratory of Clinical and Ecological Immunology

Since 2012 – leading researcher of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology

Since 2017 – member of the Academic Council of Mental Health Research Institute of Tomsk NRMC

Area of scientific and clinical interests

Issues of clinical picture and therapy of schizophrenia, psychoneuroimmunology, clinical psychopharmacology, pathophysiology, immune system

She is author and co-author of more than 150 publications including two monographs “Technology of immunocorrection” and “Immunity system and psychological defense in mechanisms of psychoemotional stress”, 5 medical technologies, 3 guidelines and guidebooks for physicians. She has 7 Russian patents for innovations.

Main direction of scientific research:

Study of psychoneuroimmune mechanisms of formation of compensatory-adaptive behavior of schizophrenic pateints; development of new approaches to therapy of endogenous psychoses based on revealed disturbances of neuroimmune interaction; study of the contribution of immunobiological factors into mechanisms of formation of resistance to psychopharmacotherapy and immunotropic effects of antipsychotics, detection of clinical-biological predictors of prognosis of course and efficiency of psychopharmacotherapy, development of evidence-based approaches to person-centered therapy of pateints with mental disorders based on clinical-biological criteria.

Member of public organization “Tomsk Professors’ Assembly”

Achievements, awards, grants

Certificate of Honor of the Presidium of SB RAMS (2003), Certificate of Honor of the Presidium of TSC SB RAMS (2006), Certificate of Honor of the Presidium of the Russian Academy of Medical Sciences (2012), Certificate of Honor of the Administration of city of Tomsk (2012, 2017), Letter of Thanks of the Administration of the Tomsk Region (2009), certificates and letters of thanks of the administration of Mental Health Research Institute.

• Implementation of themes of research work within the framework of state contracts of subprogram “Mental disorders” of the Federal target program “Prevention and control of socially significant diseases”, 2007-2011, executing officer
• Grant of RHSF no. 12-06-00752 “Development of pathodynamic model of mental disadaptation based on immunobiological and psychological criteria”, 2012-2014, executing officer
• Grant RSF no.14-15-00183 “Cytokine-mediated mechanisms of nociception and pathological olfaction in the evaluation of risk of predisposition to substance dependence”, 2014–2016, executing officer

Monographs and chapters in monographs

1. Technology of immunocorrection in mental disorders / T.P. Vetlugina, T.I. Nevidimova, O.A. Lobacheva, V.B. Nikitina. – Tomsk: Publishing House of Tomsk University, 2010. – 172 p.; 22 cm – Bibliography: p. 148―167. DOI: 10.17513/np.103. http://elibrary.ru/item.asp?id=19559803
2. Immunity system and psychological defense in mechanisms of psychoemotional stress / V.B. Nikitina, T.P. Vetlugina, O.A. Lobacheva, T.I. Nevidimova, I.Ya. Stoyanova. – Izhevsk: Publishing House “Knigograd”, 2014. – 124 p.   https://elibrary.ru/item.asp?id=23773927

Articles in peer-reviewed journals

Total number of publications – over 90 including 3 in the foreign press

1. Role of olfactory reactions, nociception and immunoendocrine shifts in addictive disorders Masterova Е, Nevidimova Т, Savochkina D, Nikitina V, Lobacheva O, Vetlugina T, Bokhan N. // The American Journal on Addictions. 2017. Vol. 26, Issue 6. P. 640–648. DOI: 10.1111/ajad.12580Impact Factor: 1.873. Online ISSN: 1521-0391

 2.   Adjunctive use of interferon γ inducer for treatment of patients with schizophrenia / T. P. Vetlugina, O. A. Lobacheva, S. A. Sergeeva, V. B.         Nikitina, T. I. Nevidimova, A. V. Semke // Acta Neuropsychiatr. – 2016. – No. 28(3). – Р. 149-156. DOI: 10.1017/neu.2015.60.       https://www.ncbi.nlm.nih.gov/pubmed/26567593

3.       An effect of quetiapine on the immune system of patients with schizophrenia / T. P. Vetlugina, O. A. Lobacheva, A. V. Semke, V. B. Nikitina, N. A. Bokhan // Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(7):55-58. DOI:10.17116/jnevro20161167155-58 https://www.ncbi.nlm.nih.gov/pubmed/27500878 (in Russian).

4.   Kornetova E.G., Mikilev F.F., Lobacheva O.A., Borodyuk Yu.N., Boiko A.S., Semke A.V. clinical and immunological features of hyperprolactinemia in schizophrenic patients treated with risperidone // Social and Clinical Psychiatry. – 2016. – Vol. 26. – No. 1. – P. 5––11. http://psychiatr.ru/magazine/scp/72/924 (in Russian).

5.   Psychometric evaluation of symptoms and clinical dynamics of schizophrenia in depending on constitutionally-morphological type of the patients / Mikilev F.F., Kornetova E.G., Lobacheva O.A., Kornetov A.N., Semke A.V. // Bulletin of Siberian Medicine. – 2016. – Vol. 15. - No. 2. – P. 58–64. http://elibrary.ru/item.asp?id=26128462 (in Russian).

6.   Association of cytokine production with hormone level and sensory responses during the formation of psychoactive drug addiction in men / Nevidimova T.I., Batukhtina E.I., Vetlugina T.P., Savochkina D.N., Nikitina V.B., Lobacheva O.A., Bokhan N.A. // Bulletin of Experimental Biology and Medicine. 2015. - Vol. 159. - No. 6. - P. 768-771. https://link.springer.com/article/10.1007/s10517-015-3071-x

7.   Vetlugina T.P., Nikitina V.B., Sergeeva S.A., Axenov M.M., Lobacheva O.A., Savochkina D.N., Epanchintseva E.M., Bokhan N.A. Influence of Adamantilbromphenylamine on Parameters of Immunity and Symptoms of Asthenia in Patients with Non-Psychotic Mental Disorders. Annals of the Russian academy of medical sciences. 2015;70(4):468-474. OI:10.15690/vramn.v70.i4.1414 http://vestnikramn.spr-journal.ru/jour/article/view/496 (in Russian).

8.   Idova G. V., Alperina E. L, Lobacheva O. A., Zhukova E. N., Cheido M. A., Menyavtseva T. A., Vetlugina T. P. Effect of antipsychotic amisulpride on immune reactivity // Experimental and Clinical Pharmacology. – 2013. – Vol. 76. – No. 5. – P. 14-17. DOI: https://doi.org/10.30906/0869-2092-2013-76-5-14-17 http://www.ekf.folium.ru/index.php/ekf/article/view/68 (in Russian).

9.   Vetlugina T.P., Lobacheva O.A., Al'perina E.L., Zhukova E.N., Semke A.V., Nikitina V.B., Cheido M.A., Idova G.V. Clinical and experimental research of immunomodulatory effect of amisulpride. Annals of the Russian academy of Medical Sciences. 2012;67(12):13-17. DOI:10.15690/vramn.v67i12.475http://vestnikramn.spr-journal.ru/jour/article/view/230 (in Russian).

10.   Vetlugina T.P., Tur'ianov T.A., Semke A.V., Tur'ianov A. Kh., Lobacheva O.A., Iuldashev V.L., Illarionova I.G. Immunological reactivity in schizophrenic patients (antitoxic immunity to diphtheria) // Zh Nevrol Psikhiatr Im S S Korsakova. – 2009. – Vol. 109. – No. 2. – P. 63-65. http://elibrary.ru/item.asp?id=13123403 (in Russian).