Personalities

Daria A. Kamayeva (Parshukova)

Daria A. Kamayeva, Ph.D., researcher of the Laboratory of Molecular Genetics and Biochemistry,    Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Scientific Secretary of the Tomsk Regional Branch of the Council of Young Scientists of the Russian Society of Psychiatrists, Deputy Chairman for Research of the Council of Young Scientists of the Mental Health Research Institute of the Tomsk National Research Medical Center, Russian Academy of Sciences.

Contact details

e-mail: Susl2008@yandex.ru
tel.: 8 (3822) 72-38-32

Brief Biography

In 2014, she graduated from the Faculty of Medicine and Biology of the Siberian State Medical University with a degree in Medical Biochemistry. She has a diploma of postgraduate professional education and a certificate of a specialist in the specialty “clinical laboratory diagnostics”. In 2019, she defended her Ph.D. thesis on the topic “Abzymes hydrolyzing myelin basic protein in patients with schizophrenia” in the specialty 03.01.04 – biochemistry. Since 2020, she has been continuing to work at the Mental Health Research Institute as a researcher.

Research Interests

Biological psychiatry, biocatalysis, catalytic antibodies, neuroimmunology, neuroinflammation, schizophrenia, metabolic syndrome.

Achievements¸ Awards, Grants

1. Member of the Russian Biochemical Society), member of the Tomsk regional branch of the Council of Young Scientists of the Russian Society of Psychiatrists, member of the Council of Young Scientists of Mental Health Research Institute of Tomsk National Research Medical Center of the Russian Academy of Sciences.

2. Laureate of the Prize of the Legislative Duma of the Tomsk Region for young scientists and young talents (2019).

3. Laureate of the Tomsk Region Prize in the field of education, science, healthcare and culture for the title in the nomination “Awards for young scientific and scientific-pedagogical workers, specialists, doctoral students and postgraduate students under the age of 35 inclusive” (2020).

4. Laureate of the Presidential Scholarship SP-2635.2019.4 “Proteolytic activity of IgG in patients with schizophrenia depending on the clinical features of the course of the disease" (2019-2021).

5. She is a laureate of the 2018-2019 internship program for young scientists “The ECNP Research internship” (University of Heidelberg, Mannheim, 2019).

6. RFBR grant no. 15-34-51233 “Study of the proteolytic properties of immunoglobulins G in the blood of patients with schizophrenia” 2015. Investigator.

7. RSF grant no. 14-15-00480 “Search for key biomarkers of the pathogenesis of socially significant endogenous mental disorders” 2014-2016. Investigator.

8. RFBR grant no. 17-34-50116 “MBP-hydrolyzing activity of antibodies depending on the clinical forms of schizophrenia” 2017. Investigator.

9. Contract for the implementation of research work “Development of a technology for predicting the metabolic side effects of antipsychotic therapy in schizophrenia based on the study of the role of endothelial nitric oxide synthase” of the program of the Presidium of the Russian Academy of Sciences 1.42 2018-2020. Investigator.

10. RSF grant no. 18-15-00053 “Search for peripheral markers associated with impaired brain myelination and disease pathogenesis in schizophrenia”. 2018-2020. Investigator.

11. RNF grant no. 18-15-00011 “Schizophrenia associated with metabolic syndrome: clinical and constitutional factors and molecular markers”. 2018-2020. Investigator.

12. Grant from the Federal State Budgetary Institution “Fund for Assistance to the Development of Small Forms of Enterprises in the Scientific and Technical Sphere” (Innovation Assistance Fund) based on the results of the XII Regional Review Competition of Innovative Projects of the UMNIK-2014 program. 2015-2016. Project Coordinator

13. RSF grant no. 21-75-00071 “Proteolytic activity of catalytic antibodies in major endogenous mental disorders: perspectives in differential diagnosis and evaluation of the prognosis of the course of schizophrenia and bipolar affective disorder” 2021-2023. Project Coordinator

Monographs and chapters in monographs

Parshukova DA and Leonard B. Immune inflammation and depression: the role of cytokines. In the book: Depressive disorders: pathogenesis hypotheses and potential biological markers / Ivanova SA, Losenkov IS, Levchuk LA, Boyko AS, Vyalova NM, Simutkin GG, Bokhan NA. Novosibirsk: Publishing House of the Siberian Branch of the Russian Academy of Sciences, 2018. P.135-151 (in Russian).

The most significant publications

Daria Andreevna is an author of 76 publications in the Russian and foreign press (incl. abstracts and materials of conferences) of which 14 articles in journals of the list of HAP, 14 articles were published in editions indexed in the system of RISC, 11 full-text articles in Web of Science, two medical technologies, two 2 intellectual products. H-index in RISC is 5, H-index in Web of Science is 5(on 23.08.2022).

1. Smirnova LP, Parshukova DA, Borodyuk YuN, Kornetova EG, Tkacheva GD, Seregin AA, Burdovitsina TG, Semke AV. Lipid spectrum changes and ECG in patients with paranoid schizophrenia in the course of therapy with atypical antipsychotics. SS Korsakov Journal of Neurology and Psychiatry. 2015, 3: 49-53. doi: 10.17116/jnevro20151153149-53 (in Russian).

2. Borodyuk YuN, Dmitrieva EG, Kornetova EG, Lobacheva OA, Smirnova LP, Parshukova DA, Kozlova SM, Semke AV. Features of adaptation of patients with paranoid schizophrenia during neuroleptic therapy with the risk of developing metabolic syndrome (with altered indicators of lipid metabolism in blood serum). Siberian Herald of Psychiatry and Addiction Psychiatry. 2015; 2(87):86-91. https://elibrary.ru/item.asp?id=23839475 (in Russian).

3. N Fattakhov, L Smirnova, D Atochin, D Parshukova, D Skuratovskaia, Q Painter, P Zatolokin, A Semke, L Litvinova, S Ivanova Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients. International Journal of Obesity. 2018; https://doi.org/10.1038/s41366-018-0124-z (Scopus SJR – 2,65, Web of Science IF = 5.151)

4. Parshukova D, Smirnova L, Ermakov E, Bokhan N, Semke A, Ivanova S, Buneva V, Nevinsky G. Autoimmunity and immune system dysregulation in schizophrenia: IgGs from sera of patients hydrolyze myelin basic protein. Journal of Molecular Recognition. 2018. First published: 15 August 2018. https://doi.org/10.1002/jmr.2759 (Scopus SJR – 0,62; Web of Science IF – 1,868)

5. Smirnova LP, Parshukova DA, Ermakov EA, Dmitrieva EM, Boyko AS, Fedorenko OYu, Loginova LV, Krotenko NM, Seregin AA, Letova AA, Sinyansky LE, Kornetova EG, Ivanova SA. Results of the search for biomarkers of schizophrenia. Siberian Herald of Psychiatry and Addiction Psychiatry. 2018; 2:33-44. https://doi.org/10.26617/1810-3111-2018-2(99)-33-44 (RISC IF 0.342, HAP) (in Russian).

6. EG Kornetova, SD Koval, AN Kornetov, DA Parshukova, SA Ivanova, AV Semke, SV Gusakova, NA Bokhan. Brain pathology in schizophrenia: connection with clinical and constitutional factors. Yakut Medical Journal. 2019; 1(65): P.17-21. DOI 10.25789/YMJ.2019.65.05 (WOS, RSCI, HAP, IF = 0.107) (in Russian).

7. DA Parshukova, VN Buneva, EG Kornetova, DV Kazantsev, AR Vasilyeva, SA Ivanova, LP Smirnova. Autoantibodies to myelin basic protein in patients with schizophrenia have proteolytic activity. Russian Journal of Immunology. 2019; 13(22):2-3:451-454 (RSCI, HAP IF = 0.512)

8. DA Parshukova, LP Smirnova, EG Kornetova, AV Semke, VN Buneva, and SA Ivanova Igg-Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia. J. Immunol. Res. 2020; Article ID 8986521, 12 pages. https://doi.org/10.1155/2020/8986521. (IF = 3.327, Scopus SJR Q1, WOS JCR Q3)

9. Ermakov EA, Parshukova DA, Nevinsky GA, Buneva VN. Natural catalytic Iggs hydrolyzing histones in schizophrenia: Are they the link between humoral immunity and inflammation? Int. J. Mol. Sci. 2020, 21(19), 7238; https://doi.org/10.3390/ijms21197238 Scopus Q1 SJR 1,32 Web of Science Q1 IF 4,556

10. Mednova IA, Boiko AS, Kornetova EG, Parshukova DA, Semke AV, Bokhan NA, Loonen AJM, Ivanova SA. Adipocytokines and Metabolic Syndrome in Patients with Schizophrenia. Metabolites 2020, 10(10), 410. https://doi.org/10.3390/metabo10100410 (Scopus Q2 SJR 0,88 Web of Science Q2 IF 4,097)

11. Evgeny A Ermakov, Elena M Dmitrieva, Daria A Parshukova, Daria V Kazantseva, Alisa R Vasilieva, Liudmila P Smirnova. Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives. Oxidative Medicine and Cellular Longevity. 2021: Article ID 8881770, 37 pages. https://doi.org/10.1155/2021/8881770   (Scopus Q1 SJR 1,39; Web of Science Q2 IF= 5,076)

12. Smirnova LP, Yarnykh VL, Parshukova DA, Kornetova EG, Semke AV, Usova AV, Pishchelko AO, Khodanovich MY, Ivanova SA. Global hypomyelination of the brain white and gray matter in schizophrenia: quantitative imaging using macromolecular proton fraction. Transl Psychiatry. 11, 365 (2021). (WOS, Scopus, Q1, IF = 7.097) https://doi.org/10.1038/s41398-021-01475-8

13. Melamud M. Mark, Ermakov A. Evgeny, Boiko S. Anastasiia, Parshukova A. Daria, Sizikov E. Alexey, Ivanova A. Svetlana, Nevinsky A. Georgy and Buneva N. Valentina*, Serum Cytokine Levels of Systemic Lupus Erythematosus Patients in the Presence of Concomitant Cardiovascular Diseases, Endocrine, Metabolic & Immune Disorders - Drug Targets 2022; 22(8) . https://dx.doi.org/10.2174/1871530322666220304214512

14. Kamaeva, D.A.; Smirnova, L.P.; Vasilieva, S.N.; Kazantseva, D.V.; Vasilieva, A.R.; Ivanova, S.A. Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein. Int. J. Mol. Sci. 2022, 23, 7397. https://doi.org/10.3390/ijms23137397 Scopus Q1 SJR 1,18 Web of Science Q1 IF 6,2