Personalities

Marina E. Poluektova

Marina E. Poluektova , Ph.D. of Biological Sciences, Senior Research Officer of laboratory of pharmacology of the reproductive system, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences.

Contact details

e-mail: marikotomsk@gmail.com
Phone: +7-906-954-78-82

Brief Biography

Poluektova Marina Evgenievna graduated from the pharmaceutical faculty of the Tomsk State Medical Institute in june 1992. She was accepted as a research assistant at the Laboratory of Drug Toxicology at the Scientific Research Institute of Pharmacology, Tomsk Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences in September of the same year. Poluektova Marina Evgenievna defended her thesis on "Early and long-term effects of the damaging effects of platinum-containing antitumor drugs on the reproductive system and the offspring of rats" for the degree of candidate of biological sciences in 1998. In October 2009, she was promoted to the position of senior research associate in the laboratory of pharmacology of the reproductive system. She has been a member of the Quality Assurance Service of the Scientific Research Institute of Pharmacology and Reproductive Medicine behalf E.D. Goldberg since april 2011.

Research Interests

Poluektova Marina Evgenievna has been studying the gonadotoxic effects of cytostatic chemotherapy and searching for new drugs for treating male infertility of various origins over the years. She is the author and co-author of more than 80 publications, 58 of them are indexed in RSTI, 19 - in Scopus, 15 - in the Web of Science. She has 4 Russian patents for inventions of the Russian Federation. The main scientific research is related to the development of methods for evaluating the reproductive toxicity of drugs, the search for new models of pathological conditions of the reproductive organs, the search for means of treating diseases of the male reproductive sphere and, above all, male infertility of various origins. Poluektova M.E. is an expert in assessing the embryotoxic and teratogenic properties of new drugs. The research results were reported at the summit on pharmacology (Chicago 2014), at the International Scientific and Practical Conference "High Technologies, Basic and Applied Research in Physiology and Medicine" (St. Petersburg, 2014).

Achievements, awards, and grants

M.E. Poluektova М.E. took an active part in assessing the toxicity of more than 20 new drugs. Many of them are already used in the treatment of a number of diseases. Specific activity of three new drugs was studied with the participation of Poluektova M.E., two of them are used in clinical practice. She received thanks from the State Duma of Tomsk Region and the Council of Rectors of Tomsk Region in 2009 and 2014. Poluektova M.E. has co-performer 14 grants within the framework of the Federal Target Program “Development of the Medical and Pharmaceutical Industry of the Russian Federation for the Period up to 2020 and Further Perspective” since 2013. Work is underway on another five topics of this FTP in 2018 year.

Main Publications

1. Borovskaya, T.G., Kamalova, S.I., Krivova, N.A., Zaeva, O.B., Poluektova, M.E., Vychuzhanina, A.V., Grigor’eva, V.A., Plotnikov, M.B., Goldberg, V.E. Experimental Study of the Effectiveness of Phenolic Antioxidants in Male Infertility Caused by Pathospermia // Bulletin of Experimental Biology and Medicine. – 2018. - 166 (1). – P. 7-10. DOI: 10.1007/s10517-018-4276-6.


2. Borovskaya, T.G., Kamalova, S.I., Polyektova, M.E., Mashanova, V.A., Vychuzhanina, A.V., Kseneva, S.I., Plotnikov, M.B., Goldberg, V.E. Experimental Analysis of the Efficacy of Dihydroquercetin on the Model of Chronic Nonbacterial Inflammation of the Prostatic Gland // Bulletin of Experimental Biology and Medicine. – 2018. - 164 (5). – P. 617-619. DOI: 10.1007/s10517-018-4044-7.


3. Боровская Т.Г., Камалова С.И., Полуэктова М.Е., Машанова В.А., Вычужанина А.В., Ксенева С.И., Плотников М.Б., Гольдберг В.Е. Экспериментальное исследование эффективности дигидрокверцетина на модели хронического абактериального воспаления предстательной железы // Бюллетень экспериментальной биологии и медицины. - 2017. - Т164, №11ю - С.570-573. (http://www.iramn.ru/journal/bebm/2017/bbm1711.htm).


4. Borovskaya, T.G., Poluektova, M.E., Vychuzhanina, A.V., Mashanova, V.A., Shchemerova, Y.A. Experimental Assessment of the Effect of Kagocel on Reproductive Function in Pubertal Male Rats // Bulletin of Experimental Biology and Medicineю. – 2017. - 163 (2). – Р. - 214-217. DOI: 10.1007/s10517-017-3769-z.


5. Боровская Т.Г., Полуэктова М.Е., Вычужанина А.В., Машанова В.А., Щемерова Ю.А.  Влияние препарата кагоцел на генеративную функцию экспериментальных животных при введении в инфантильном периоде их развития // Токсикологический вестник. - 2017. - №3. - С. - 42-49. (http://toxreview.ru/magazine/?c4a=20170300).


6. Боровская Т.Г., Полуэктова М.Е., Вычужанина А.В., Машанова В.А., Щемерова Ю.А. Экспериментальная оценка влияния препарата кагоцел на генеративную функцию крыс-самцов пубертатного возраста // Бюлл. эксперим. биол. и мед. - 2017. - Т163, №2. - С.176-179. (http://www.iramn.ru/journal/bebm/2017/bbm1702.htm  DOI: 10.1007/s10517-017-3769-z).


7. Borovskaya, T.G., Dygai, A.M., Shchemerova, Y.A., Kamalova, S.I., Mashanova, V.A., Vychuzhanina, A.V., Poluektova, M.E., Madonov, P.G., Kinsht, D.N., Goldberg, V.E. Effect of granulocyte colony-stimulating factor immobilized by the electron-beam synthesis nanotechnology on reparative regeneration of spermatogenous tissue // Bulletin of Experimental Biology and Medicine. – 2016. - 161 (5). – Р.683-686. DOI: 10.1007/s10517-016-3485-0.


8. Borovskaya T.G. Poluektova M.E, Vychuzhanina A.V., Shchemerova Y.A. and Goldberg V.E. Experimental stady of long – term effects of different drugs on female reproduction system and posterity: Pharmacological way to reduce.// Journal of Clinical Toxicology Open Access. Toxicology. - 2015. - Volume 5, Issue 3. – Р.46-47. http://dx.doi.org/10.4172/2161-0495.S1015.


9. Borovskaya T.G., Krivova N.A., Zaeva O.B., Fomina T.I., Kamalova S.I., Poluektova M.E., Vychuzhanina A.V., Shchemerova Y.A., Grigor’eva V.A., Goldberg V.E., Plotnikov M.B. Dihydroquercetin Effects on the Morphology and Antioxidant/Prooxidant Balance of the Prostate in Rats with Sulpiride-Induced Benign Hyperplasia // Bulletin of Experimental Biology and Medicine. – 2015. - 158 (4). – Р.513-516. DOI: 10.1007/s10517-015-2797-9.


10. Borovskaya T.G., Shchemerova Y.A., Poluektova M.E., Vychuzhanina A.V., Goldberg V.E., Kinsht D.N., Yershov K.I., Madonov P.G. Mechanisms of reparative regeneration of rat testis after injection of paclitaxel // Bulletin of Experimental Biology and Medicine. – 2014. - 156 (4). – Р.483-485. DOI: 10.1007/s10517-014-2380-9.


11. Borovskaya T.G., Dygai A.M., Shchemerova Y.A., Vychuzhanina A.V., Poluektova M.E., Goldberg V.E., Kinsht D.N., Ershov K.I., Madonov P.G. Pharmacological stimulation of the regenerative capacity of rat testes damaged by paclitaxel // Bulletin of Experimental Biology and Medicine. – 2014. - 156 (6). – Р.773-775. DOI: 10.1007/s10517-014-2446-8.


12. Poluektova M.E., Borovskaya T.G., VyshuzhaninaA.V., Goldberg V.E. Comparative assessment of the offspring of female rats obtained long-term after cyto-static influences of different types // Journal of Clinical Toxicology. – 2014. - №4. – Р.121 doi: 10.4172/2161-0495.S1.013.


13. Borovskaya T.G.; Fomina T.I., Pahomova A.V., Schemerova J.A., Poluektova M.E., Vychuzhanina A.V., Kamalova S.I., Ermolaeva L.A. Experimental study of efficiency of Tertapeptide Lysil-Glutamyl-Aspartyl-Proline using the model of benign prostatic hyperplasia // Modern Research in Inflammation. – 2014. - № 3. - Р.108-112 doi:10.4236/mri.2014.33013.


14. Borovskaya T.G., Fomina T.I., Ermolaeva L.A., Vychuzhanina A.V., Pakhomova A.V., Poluektova M.E., Shchemerova Y.A. Comparative evaluation of the efficiency of prostatotropic agents of natural origin in experimental benign prostatic hyperplasia // Bulletin of Experimental Biology and Medicine. - 2013. - 155 (1). – Р.67-70. DOI: 10.1007/s10517-013-2081-9


15. Zhavbert E.S., Dugina I.L., Borovskaia T.G., Kheǐfets I.A., Épshteǐn O.I., Poluéktova M.E., Vychuzhanina A.V., Shemerova I.A., Pakhomova A.V. An experimental study of the effectiveness of the drug afalaza in chronic aseptic prostatitis // Urologii{combining double inverted breve. – 2013. - № 1. - Р.50-53.


16. Borovskaya T.G., Pakhomova A.V., Vychuzhanina A.V., Poluektova M.E., Fomina T.I., Experimental studying of the drug efficiency Prostamax in the therapy of chronic aseptic prostatitis and its complications // Modern Research in Inflammation. – 2013. - Vol.2, N. – Р. 354-58 doi:10.4236/mri.2013.23007.


17. Borovskaya T.G., Fomina T.I., Pakhomova A.V., Ermolaeva L.A., Poluektova M.E., Zhavbert E.S., Dugina Ju.L., Kheifets I.A., Epstein O.I. Experimental study of the efficiency of impaza on the model of chronic aseptic prostatic inflammation // Bulletin of Experimental Biology and Medicine. – 2012. - 154 (2). – Р.217-219. DOI: 10.1007/s10517-012-1916-0.


18. Borovskaja T.G., Sergeeva S.A., Udut V.V. Fomina T.I., Jurmazov Z.A., Pahomova A.V., Poluektova M.E., Chemerova J.A., Rumpel' O.A. Modification of sulpiride model of benign prostatic hyperplasia for evaluation of the effectiveness of drug therapy // Bulletin of Experimental Biology and Medicine. – 2011. - 151 (5). – Р.588-592. DOI: 10.1007/s10517-011-1389-6.


19. Боровская Т.Г, Гольдберг В.Е., Полуэктова М.Е и др. Сравнительная экспериментальная оценка отдаленных последствий гонадотоксичности цитостатических препаратов разныхгрупп. Экспериментальное изучение эффективность фармакотерапии, как способа снижения гонадотоксичности цитостатических воздействий // «Рак и репродукция»/ под. Ред А.А. Параконной, Москва. Галеон. - 2011. - С.184-190. http://elibrary.ru/item.asp?id=24829546


20. Боровская Т.Г., Гольдберг В.Е., Румпель О.А., Пахомова А.В., Перова А.В., Гольдберг Е.Д. Состояние сперматогенеза крыс после введения противоопухолевого препарата паклитаксела // Бюлл. экспер. биол. и мед. - 2009. – Т. 147, №6. - С. 655-658. http://elibrary.ru/item.asp?id=15179086.


21. Borovskaya T.G., Goldberg V.E., Rumpel O.A., Perova A.V., Pakhomova A.V., Poluektova M.E. Influence of taxan-containing cytostatic preparations on the progeny // Vestnik Rossiiskoi Akademii Meditsinskikh Nauk. – 2009. - № 11. – Р.26-30.


22. Borovskaya T.G., Perova A.V., Pachomova A.V., Poluektova M.E., Gol'dberg V.E. The stage of offspring of female rats after treatment with cytostatics of various groups Bulletin of Experimental Biology and Medicine. – 2008. - 146 (4). Р. 429-432. DOI: 10.1007/s10517-009-0307-7.


23. Borovskaya T.G., Gol'dberg V.E., Poluektova M.E., Timina E.A., Shchemerova Yu.A., Perova A.V. Effect of vepeside on the function of reproductive system in rats // Bulletin of Experimental Biology and Medicine. – 2005. - 140 (3). – Р. 317-319. DOI: 10.1007/s10517-005-0478-9.


24. Боровская Т.Г., Гольдберг В.Е., Перова А.В. Полуэктова М.Е., Пахомова А.В., Тимина Е.А. Влияние противоопухолевых препаратов на эстральный цикл крыс // Бюлл. экспериментальной биологии и мед. – 2005. - Приложение №1. – С. 31-34. http://elibrary.ru/item.asp?id=9139671.


25. Borovskaya T.G., Gol'dberg V.E., Poluektova M.E., Pakhomova A.V., Timina E.A., Gol'dberg E.D. Status of the progeny of rats treated with platinum-containing cytostatics // Bulletin of Experimental Biology and Medicine. – 2004. - 138 (3). – Р.267-270. DOI: 10.1007/s10517-005-0018-7.


26. Borovskaya T.G., Goldberg V.E., Fomina T.I., Pakhomova A.V., Kseneva S.I., Poluektova M.E., Goldberg E.D. Morphological and functional state of rat ovaries in early and late periods after administration of platinum cytostatics // Bulletin of Experimental Biology and Medicine. - 137 (4). – Р. 331-335.. DOI: 10.1023/B.


27. Боровская Т.Г., Гольдберг В.Е., Фомина Т.И., Пахомова А.В, Ксенева С.И., Полуэктова М.Е., Гольдберг ЕД. Морфологическое и функциональное состояние яичников в ранние и в отдаленные сроки после введении платиносодержащих цитостатических препаратов // Бюллетень экспериментальной биологии и медицины. – 2004. - Т. 137, №4. - С. 374-378. http://elibrary.ru/item.asp?id=24858816


28. Гольдберг Е.Д., Боровская Т.Г., Полуэктова М.Е. Влияние противоопухолевых препаратов на потомство // Бюллетень экспериментальной биологии и медицины. 2000. - N4. - С. 437-439.


29. Gol'dberg E.D., Borovskaya T.G., Poluektova M.E. Effects of antitumor drugs on offspring // Bulletin of Experimental Biology and Medicine. – 2000. - 129 (4). – Р.367-369. DOI: 10.1007/BF02439273.


30. Karpova G.V., Fomina T.I., Vetoshkina T.V., Borovskaya T.G., Voronova O.L., Dubskaya T. Yu., Poluektova M.E., Timina E.A., Smol'yaninov E.S., Turetskova V.F. Preclinical toxicological characterization of ecorsin // Eksperimental'naya i Klinicheskaya Farmakologiya. – 2000. - 63 (4). – Р. 63.


31. Borovskaya T.G., Smirnova M.E., Gol'dberg E.D. Effect of platinum-containing cytostatics on rat progeny // Bulletin of Experimental Biology and Medicine. – 1997. - 124 (11). – Р.1075-1077.


32. Borovskaia T.G., Smirnova M.E., Gol'dberg E.D. Effect of the platinum-containing cytostatics on the rat offspring [Article@Vliianie platinosoderzhashchikh tsitostaticheskikh preparatov na potomstvo krys.] // Biulleten' eksperimental'noi biologii i meditsiny. – 1997. - 124 (11). – Р.516-519.


33. Borovskaya T.G., Smirnova M.E., Filippova M.V., Fomina T.I., Gol'dberg V.E. Long-term effects of the platidiam toxic action on rat posterity // Eksperimental'naya i Klinicheskaya Farmakologiya. – 1996. - 59 (4). – Р. 42.


34. Gol'dberg E.D., Borovskaia T.G., Fomina T.I., Smirnova M.E. Morphofunctional state of rat ovaries after administration of platidiam [Article@Morfofunktsional'noe sostoianie iaichnikov krys posle vvedeniia platidiama.] // Biulleten' eksperimental'noi biologii i meditsiny. – 1996. - 122 (11). – Р. 571-573


35. Gol'dberg E.D., Borovskaya T.G., Fomina T.I., Smirnova M.E. Morphofunctional status of the ovaries in platidiam-treated rats // Bulletin of Experimental Biology and Medicine. – 1996. – 122 (11). – Р.1144-1146.


36. Borovskaia T.G., Smirnova M.E., Filippova M.V., Fomina T.I., Gol'dberg V.E. The late effects of the toxic action of platinum-containing cytostatic preparations on rat progeny [Article@Otdalennye éffekty toksicheskogo deistviia platinsoderzhashchikh tsitostaticheskikh preparatov na potomstvo krys.] // Eksperimental'naia i klinicheskaia farmakologiia. – 1996. - 59 (4). – Р. 40-42.


37. Borovskaya, T.G., Fomina, T.I., Filippova, M.V., Smirnova, M.E., Goldberg, V.E. The rat testis morphology in early and remote period after platidiam administration // Eksperimental'naya i Klinicheskaya Farmakologiya. – 1996. - 59 (2). – Р.43.


38. Gol'dberg E.D., Borovskaia T.G., Fomina T.I., Skorokhodova M.G., Smirnova M.E. Long-term effects of the harmful action of anthracycline antibiotics on the rat reproductive system [Article@Otdalennye éffekty povrezhdaiushchego deistviia antibiotikov antratsiklinovogo riada na reproduktivnuiu sistemu krys.] // Biulleten' eksperimental'noi biologii i meditsiny. - 121 (1). – Р.55-58.


39. Gol'dberg E.D., Borovskaya T.G., Fomina T.I., Skorokhodova M.G., Smirnova M.E. Delayed damaging effects of anthracycline antibiotics on the reproductive system of rats // Bulletin of Experimental Biology and Medicine. – 1996. - 121 (1). – Р. 50-52. DOI: 10.1007/BF02445705.