Personalities

Larisa A. Miroshnichenko

Larisa A. Miroshnichenko, MD, DSc, Senior Researcher of the Laboratory of Pathophysiology and Experimental Therapy of Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center.

Contact details

Tel: +7 (3822) 41-83-72
Fax: +7 (3822) 41-83-79 E-mail: laarmi@yandex.ru

Brief Biography

In 1998, she graduated from the Medico-Biological Faculty of the Siberian State Medical University, Tomsk (SSMU). From 1998 to 2001, she had a postgraduate study in Research Institute of Pharmacology (Tomsk) and got a PhD degree. From 2001 to 2013, she held a position of a researcher of Laboratory of Pathophysiology and Experimental Therapy Research institute of Pharmacology (Tomsk). In 2012, she got DSc degree. From 2014 till present , she is a senior researcher of Laboratory of Pathophysiology and Experimental Therapy, Research Institute of Pharmacology.

Scientific interests

Larisa A. Miroshnichenko is a specialist in the field of pharmacology, pathophysiology and regenerative medicine. Her main research interest is the study of the role of progenitor cells of various classes in the development and resolution of pathological processes and the development of drugs for regenerative medicine. L. A. Miroshnichenko is the author of 140 scientific works, «The methodical recommendations on the study of specific activity drugs for regenerative medicine" and "The methodical recommendations on the study of haemostimulation activity of pharmacological substances". She has 24 patents for inventions.

Achievements, awards, grants

• Winner of the Young Scientists Competition of the Siberian Branch of the Russian Academy of Medical Sciences (2000)
• Winner of the Tomsk Region Competition in Education and Science (2003)
• Winner of the Competition Tomsk region in the field of education, science, health and culture (2010)
• Grant of the President of the Russian Federation for the Support of Young Russian Scientists and Leading Scientific Schools (2003-2005)
• Participation in the Federal target program "PHARMA 2020" and Federal target program "Scientific and scientific-pedagogical staff of innovative Russia" at 2009-2013"
• Russian Foundation for Basic Research grants (2009, 2018)

Main Publications

1. Patent RU № 2514648 «Haemostimulating agent» (published 24.07.2014, Newsletter No. 12). Authors: Zuz′kov G.N., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Suslov N.I., Povet′eva T.N., Dygai A.M. (http://www1.fips.ru/Archive/PAT/2014FULL/2014.04.27/DOC/RUNWC1/000/000/002/514/648/document.pdf).


2. Patent RU № 2535021 «Haemostimulating agent» (published 10.12.2014, Newsletter, no. 34). Authors: Zuz′kov G.N., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Suslov N.I., Povet′eva T.N., Dygai A.M. (http://www1.fips.ru/Archive/PAT/2014FULL/2014.01.27/DOC/RUNWC1/000/000/002/505/308/document.pdf).


3. Patent RU № 2589288 “Method for stimulating production of erythropoietin in a cell culture in vitro” (published 10.12.2014, Newsletter, no. 34). Authors: Dygai A., Zdanov V.V., Zuz′kov G.N., Miroshnichenko L.A., Udut E.V., Khrichkova T.Yu., Simanina E.V., e.a. (http://www.fips.ru/Archive4/PAT/2016FULL/2016.07.10/DOC/RUNWC1/000/000/002/589/288/document.pdf).


4. Patent RU № 2599289 «Tissue regeneration stimulating agent» (published 10.10.2016, Newsletter № 28). Authors: Zyuz’kov G. N., Zhdanov V. V., Danilets M.G., Miroshnichenko L.A., Udut E.V. http://www.fips.ru/Archive4/PAT/2016FULL/2016.10.10/DOC/RUNWC2/000/000/002/599/289/DOCUMENT.PDF


5. Zyuzkov G.N., Danilets M.G., Ligacheva A.A., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Chaikovskii A.V., Trofimova E.S., Minakova M.Y., Udut V.V., Dygai A.M. PI3K, MAPK EPK1/2 and p38 are involved in the realization of growth potential of mesenchymal progenitor cells under the infl uence of basic fibroblast growth factor // Bulletin of Experimental Biology and Medicine. (Published: Springer Science+Business Media, Inc., New York, USA). 2014, Vol. 157, № 4, P. 436-439. (DOI: 10.1007/s10517-014-2584-z) (http://link.springer.com/article/10.1007/s10517-014-2584-z; IF 2016 JCR Science Edition 0,456).


6. Dygai A.M., Zhdanov V.V., Zyuzkov G.N., Udut E.V., Miroshnichenko L.A., Simanina E.V., Chaikovskii A.V., Stavrova L.A., Danilets M.G., Agafonov V.I., Khrichkova T.Y. Involvement of NF-κB-dependent signaling and p38 mapk signaling pathway in the regulation of hemopoiesis during restrain stress // Bulletin of Experimental Biology and Medicine. (Published: Springer Science+Business Media, Inc., New York, USA). 2014, Vol. 157, № 5, P. 548-551. (DOI: 10.1007/s10517-014-2611-0) (http://link.springer.com/article/10.1007/s10517-014-2611-0; IF 2016 JCR Science Edition 0,456).


7. Zyuz’kov G.N., Amosova E.N., Chaikovskii A.V., Miroshnichenko L.A., Udut E.V. е.а. Antitumor effects of JAK3 inhibitor on the model of transplantable lewis lung carcinoma and mechanisms of their development // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2016, Vol. 161, № 3, P. 367-370. (DOI: 10.1007/s10517-016-3415-1) (http://link.springer.com/article/10.1007/s10517-016-3415-1; IF 2016 JCR Science Edition 0,456).


8. Zyuz’kov G. N., Zhdanov V. V., Udut E. V., Miroshnichenko L.A., Simanina E.V., Polyakova T.Yu. е.а. Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2016, Vol. 161, № 2, P. 224–227. (DOI: 10.1007/s10517-016-3381-7) (http://link.springer.com/article/10.1007/s10517-016-3381-7; IF 2016 JCR Science Edition 0,456).


9. Zyuz’kov G. N., Zhdanov V. V., Miroshnichenko L. A., Udut E.V. е.а. Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2015, Vol. 159, № 1, P. 58-61. (DOI:10.1007/s10517-015-2889-6) (http://link.springer.com/article/10.1007/s10517-015-2889-6; IF 2016 JCR Science Edition 0,456).


10. Miroshnichenko L. A., Zhdanov V. V., Udut E. V., Polyakova T. Yu., Zyuz’kov G. N., Simanina E. V., Sherstoboev E. Yu., Stavrova L. A., Agafonov V. I., Minakova M. Yu., Chaikovskii A. V., Dygai A. M. Role of NF-κB, PI3K, MAPK/ERK 1/2, and p38 in erythropoietin production by bone marrow nuclears under conditions of immobilization stress // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2017, Vol. 163, № 3, P. 352–355 (DOI:10.1007/s10517-017-3802-2) (https://link.springer.com/article/10.1007/s10517-017-3802-2; IF 2017 JCR Science Edition 0,546).


11. Zyuz’kov G. N., Suslov N. I., Povet’eva T. N., e.a. Psychopharmacological effects of JNK inhibitor in posthypoxic encephalopathy and mechanisms of their development // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2017, Vol. 163, № 1, P. 18–21. (DOI: 10.1007/s2Fs10517-017-3727-9) (https://link.springer.com/content/pdf/10.1007%2Fs10517-017-3727-9.pdf; IF 2017 JCR Science Edition 0.546).


12. Zyuz’kov G. N., Udut E. V., Miroshnichenko L. A., е.а. Role of JAK1, JAK2, and JAK3 in functional stimulation of mesenchymal precursor cells by alkaloid songorine // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2017, Vol. 163, № 4, P. 443–446. (DOI: 10.1007/s2Fs10517-017-3824-9) (https://link.springer.com/content/pdf/10.1007%2Fs10517-017-3824-9.pdf; IF 2017 JCR Science Edition 0.546).


13. Zyuzkov G.N., Udut E.V., Miroshnichenko L.A., Simanina E.V., Polyakova T.Y., Stavrova L.A., Udut V.V., Minakova M.Y., Dygai A.M., Chaikovskii A.V., Agafonov V.I., Zhdanov V.V. Role of JAK1, JAK2, AND JAK3 in functional stimulation of mesenchymal precursor cells by alkaloid songorine // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2017, Vol. 163, № 4, P. 443-446. (DOI: 10.1007/s10517-017-3824-9) (https://link.springer.com/article/10.1007/s10517-017-3824-9; IF 2017 JCR Science Edition 0.546).


14. Polyakova T.Y., Zhdanov V.V., Miroshnichenko L.A., Udut E.V., Simanina E.V., Dygai A.M., Zyuz'kov G.N., Goldberg V.E., Popova N.O., Vysotskaya V.V., Simolina E.I., Belevich Y.V., Tuzikova T.P., Goldberg A.V. Assessment of erythroid and granulocytic hematopoietic lineages in patients with non-small-cell lung carcinoma // Bulletin of Experimental Biology and Medicine. (Published: Springer Science+Business Media, Inc., New York, USA). 2017, Vol. 163. № 4. P. 469-474. (DOI: 10.1007/s10517-017-3830-y) (https://link.springer.com/article/10.1007/s10517-017-3830-y; IF 2017 JCR Science Edition 0.546).


15. Zhdanov V. V., Miroshnichenko L. A., Udut E. V., Polyakova T. Yu., Zyuz’kov G. N., Simanina E. V., Sherstoboev E. Yu., Stavrova L. A., Agafonov V. I., Minakova M. Yu., Dygai A. M. Role of Signaling Molecules in the Regulation of Granulocytopoiesis during Stress-Inducing Stimulation // Bulletin of Experimental Biology and Medicine. 2018, Vol. 166, № 3, P. 344-347 (DOI: 10.1007/s10517-019-04347-w) (http://link.springer.com/article/10.1007/s10517-019-04347-w).