Personalities

Evgeniy Yu. Sherstoboev

Evgeniy Yu. Sherstoboev, Doctor of Medical Sciences, professor, Chief Scientific Researcher, Head of the Department of Immunopharmacology of Goldberg Research Institute of Pharmacology and Regenerative Medicine of Tomsk National Research Medical Center.

Contact details

e-mail: sherstoboev_eu@pharmso.ru
Phone: +7 (3822) 41-77-05

Brief Biography

Evgeniy Sherstoboev graduated from the medical faculty of the Tomsk State Medical Institute in 1987. Since 1987, he worked at the Scientific Research Institute of Mental Health, Tomsk Scientific Center of the USSR Academy of Medical Sciences, as a psychiatrist, and then, in 1988, he moved to the Research Institute of Pharmacology, Tomsk Scientific Center of the USSR Academy of Medical Sciences. He has gone from a senior laboratory assistant to the head of the immunopharmacology department.
Since 1999 ‑ Doctor of Medical Sciences, since 2006 ‑ Professor in the specialty “Pathological physiology”, since 2002 to the present ‑ Head of the Department of Immunopharmacology at the Goldberg Research Institute of Pharmacology and Regenerative Medicine, and since 2018 ‑ Chief Scientific Researcher of the Department of Immunopharmacology of Goldberg Research Institute of Pharmacology and Regenerative Medicine of Tomsk National Research Medical Center.

Research Interests

The main direction of scientific research of Evgeniy Sherstoboev is to study the mechanisms of immunotropic effects of natural origin drugs at normal and pathological state of immune system. In particular, during the scientific work of Evgeniy Sherstoboev and under his leadership there was completed a large cycle of studies on the patterns and mechanisms of functioning of the hematopoietic and lymphoid tissues under stress and cytostatic effects, as well as methods for correcting the identified pathological changes. The features of the immune and blood systems response to a thymus-dependent antigen in mice with different genotypes in norm and after the administration of an antitumor drug (cyclophosphamide) or immobilization stress, patterns of action of various immunotropic drugs in genetically heterogeneous animals were studied. The immunotropic properties of total extracts and individual biologically active substances from more than a dozen plants of Siberia and the Far East were investigated. The materials of his research were reported and discussed at regional, All-Russian and international scientific conferences and congresses.
Evgeniy Sherstoboev directly participated in the development and study of the pharmacological properties and mechanisms of action of new immunotropic drugs ‑ Anaferon and Anaferon Children, as well as anti-inflammatory drug Arthrofoon. After carrying out the entire complex of preclinical and clinical studies of these original drugs, permits were obtained for their production and clinical use. Under the guidance of Evgeniy Yu. Sherstoboev the immunotoxic and allergenic properties of a number of new drugs — Thiophane, D-glucuronic acid, Ecorsin, Proprotene, Poetam, Afala, Artrophoon, Para-tyrosol, Mediborol, agents immobilized on polyethylene oxide — proinsulin, interferon alfa-2b, GC-CSF, oligonucleotides, hyaluronidase ‑ have been studied.
Evgeniy Sherstoboev is the author of more than 170 publications, including 2 monographs, has 15 Russian patents for inventions. Under his leadership, 2 doctoral and 6 master's theses were defended.

Achievements, awards, and grants

Evgeniy Sherstoboev takes an active part in the implementation of the federal target program “Development of the medical and pharmaceutical industry of the Russian Federation for the period up to 2020 and further perspective”. Within the frameworks of this program, the immunotoxic, allergenic and immunotropic properties of several innovative drugs were studied: sulfur hexafluoride agent for ultrasound visualization of focal formations of inflammatory genesis; hemorheological agent based on hydroxyethyl starch with 2,6-diisobornylphenol, agent based on 1-alkyl-2-alkylcarbamoylglycerol having antihypertensive activity, immobilized interferons alpha 2b and lambda, etc.
The researches of Evgeniy Sherstoboev was rewarded with a grant from the regional public “Fund for Support of Domestic Medicine” (2000, 2001), a presidential grant for supporting leading scientific schools in the Russian Federation, a grant from the “Siberian School of Pharmacology of Academician E.D. Goldberg” (2008), rewarded with a diploma of the Presidium of the Siberian Branch of the Russian Academy of Medical Sciences (May 2009).
Evgeniy Sherstoboev is a member of the Academic Council of the Goldberg Research Institute of Pharmacology and Regenerative Medicine. From 1999 to 2002, he was the secretary of the Expert Council for the examination of the efficiency and safety of medicines developed and produced in Siberia and the Far East.

Main Publications

1. Dygai A.M., Sherstoboev E.Yu., Goldberg E.D. Regulation of cytokine production in the bone marrow during postcytostatic regeneration by SC-1+ and Thy-1+ cells // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). –1998. ‑ Vol. 125. ‑ Issue 4. ‑ P. 331-333. https://elibrary.ru/item.asp?id=13276212


2. Sherstoboev E.Yu., Simanina E.V., Dygai A.M. Regulation of the processes of proliferation and differentiation of hematopoietic cells under multiple immobilization exposure // Bulletin of Experimental Biology and Medicine. ‑ 1999. ‑ Suppl. 1. ‑ P.114-118. https://elibrary.ru/item.asp?id=25746194


3. Goldberg E.D., Dygai A. M., Sherstoboev E.Yu. Mechanisms of local regulation of hemopoiesis. – Tomsk: STT, 2000. ‑148 p. https://elibrary.ru/item.asp?id=24312702


4. Sherstoboev E.Yu., Masnaya N.V., Churin A.A., Borsuk O.S. Delayed effects of Doxorubicin and Vinblastine on bone marrow reactivity in the experiment // Bulletin of Experimental Biology and Medicine. ‑ 2001. ‑ Suppl. 1. – P.13-17. http://www.iramn.ru/journal/bebm/2001/bbm011p.htm


5. Masnaya N.V., Churin A.A., Sherstoboev E.Yu., Borsuk O.S. The Reactions of the immune and hematopoietic systems to the stressing exposures of different genesis // Bulletin of Experimental Biology and Medicine. ‑ 2001. ‑ Suppl. 3. ‑ P. 60-63. https://elibrary.ru/item.asp?id=24670941


6. Marteushev A.V., Sherstoboev E.Yu., Pashinskiy V.G., Sergeeva. S.A., Epstein O.I. Anti-cytokine antibodies in ultralow doses (ULD) regulate cytokine expression: experimental and clinical aspects // Journal of Interferon and Cytokine Research. – 2002. ‑ V.22. ‑ Suppl.1. – P. 122.


7. Sherstoboev E.Yu., Masnaya N.V., Churin A.A., Borsuk O.S., Belskiy Yu.P., Martyushev A.V., Osidak L.V., Drinevsky V.P., Epstein O.I. Immunotropic properties of ultra-low doses of antibodies to gamma-interferon // Cytokines and inflammation. ‑ 2002. ‑ Issue 2. ‑ P.40. https://elibrary.ru/item.asp?id=24483766


8. Marteushev A.V., Sherstoboev E.Yu., Sergeeva S.A., Belskiy Yu.P., Dygai A.M., Goldberg E.D., Epshtein O.I. Ultralow doses of anibodies to interferon gamma (ULD anti-IFNg) as a novel immunomodulator // XIVth World Congress of Pharmacology: Meeting Abstracts, San Francisco, 2002. – Pharmacologist. – V. 44. – N 2. – 2002. – P.240.


9. Masnaya N.V., Churin A.A., Sherstoboev E.Yu., Borsuk O.S. Immune reactions in different mouse strains // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2002. – Vol. 134. – Issue 4. ‑ P. 376-378. https://elibrary.ru/item.asp?id=13392648


10. Sherstoboev E.Yu., Masnaya N.V., Churin A.A., Borsuk O.S., Martyshev A.V., Epstein O.I. Ultralow Doses of Anti-Idiotypic Antibodies to Human γ-Interferon: Immunotropic Properties // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2003. ‑ Suppl. 1. ‑ P. 67-69. https://www.ncbi.nlm.nih.gov/pubmed/12949655


11. Sherstoboev E.Yu., Kaplya O.A., Zueva E.P., Razina T.G., Epstein O.I. Influence of Baikal skullcap extract and its combination with cyclophosphamide on cytokine production during the development of Lewis lung carcinoma // Bulletin of the Russian Academy of Medical Sciences. ‑ 2004. ‑ Issue 4. ‑ P. 128-132. https://elibrary.ru/item.asp?id=9126547


12. Sherstoboev E.Yu., Minakova M.Yu. Hematopoietic precursors: regulation mechanisms under chronic stress // Cellular technologies in biology and medicine. ‑ 2005. – Issue 4. ‑ P. 215-219. https://elibrary.ru/item.asp?id=25336519


13. Sherstoboev E.Yu., Babenko A.P. Modulation of cytokine production by adrenomimetics under stress and antigenic influence // Cytokines and inflammation. ‑ 2007. ‑ Vol. 6. ‑ Issue 3. ‑ P. 40-43. https://elibrary.ru/item.asp?id=21362732


14. Disregulation pathology of the blood system / Ed. E.D. Goldberg, G.N. Kryzhanovskiy. ‑ M.: Medical Information Agency, 2009. ‑ 432 p. https://elibrary.ru/item.asp?id=21784598


15. Borsuk O.S., Masnaya N.V., Sherstoboev E.Yu., Isaykina N.V., Kalinkina G.I. Effects of drugs of plant origin on the development of the immune response // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2011. – Vol. 151. ‑ Issue 2. ‑ P. 194-196. https://elibrary.ru/item.asp?id=16996000


16. Shitikova O.G., Sherstoboev E.Yu., Masnaya N.V., Danilets M.G., Trofimova E.S., Ligachev A.A., Madonov P.G., Kinsht D.N., Ershov K.I., Shilova M.A. Development of optimal experimental therapeutic schemes for the introduction of immobilized interferon α-2b // Bulletin of Siberian Medicine. ‑ 2014. ‑ Vol. 13. – Issue 5. ‑ P. 114–121. https://elibrary.ru/item.asp?id=22854767


17. Sherstoboev E.Yu., Shitikova O.G., Masnaya N.V., Danilets M.G., Trofimova E.S., Ligacheva A.A., Madonov P.G., Kinsht D.N., Ershov K.I., Shilova M.A. Immunotropic properties of immobilized Interferon-α2b // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2016. ‑ Vol. 161. – Issue 5. ‑ P. 693-697. https://elibrary.ru/item.asp?id=35504527