Personalities

Evgenia S. Trofimova

Evgenia S. Trofimova, PhD, Senior Scientific Researcher of the Laboratory of Immunopharmacology of Goldberg Research Institute of Pharmacology and Regenerative Medicine of Tomsk National Research Medical Center.

Contact details

e-mail: trofimova_es@pharmso.ru

Brief Biography

In 1999, Evgenia Trofimova graduated from the Faculty of Medicine and Biology of the Siberian State Medical University with a degree in biophysics. All of Evgenia work activity is connected with the Research Institute of Pharmacology of the Siberian Branch of the Russian Academy of Medical Sciences, where she began working immediately as a junior research assistant after graduating from the University. In 2002, Evgenia defended her thesis in the specialty “Pathological physiology”. From 2012 to the present, he has held the position of Senior Scientific Researcher.

Research Interests

The main focus of Evgenia’s research is the study of the mechanisms of influence of plant and synthetic substances on the immune response in normal and pathological state, including studying intracellular signaling cascades and searching targets for pharmacological correction of various pathological conditions in order to further develop new drugs. Research materials of Evgenia Trofimova were presented at All-Russian and international scientific conferences. In addition to scientific activities, Evgenia Trofimova is working in the Laboratory of Immunopharmacology on the organization of research according to GLP standards. Evgenia is the author of 96 published works, including 1 monograph, has 12 patents.

Achievements, awards, and grants

In 2016, for her contribution to the development of scientific research, Evgenia was awarded a diploma of the Administration of Tomsk Region.

Main Publications

1. Belska N.V., Guriev A.M., Danilets M.G., Trophimova E.S., Uchasova E.G., Ligatcheva A.A., Belousov M.V., Agaphonov V.I., Golovchenko V.G., Yusubov M.S., Belsky Yu.P. Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response // International Immunopharmacology. ‑ 2010. – Vol. 10. ‑ Issue 8. – P. 933-942. https://www.ncbi.nlm.nih.gov/pubmed/20483383


2. Danilets M.G., Belsky Yu.P., Guriev A.M., Belousov M.V., Belskaya N.V., Trofimova E.S., Uchasova E.G., Akhmedzhanov R.R., Ligacheva A. .A., Yusubov M.S., Agafonov V.I. Effect of plant polysaccharides on Th1-dependent immune response: screening investigation // Experimental and clinical pharmacology. ‑ 2010. – Vol. 73. – Issue 6. ‑ P. 19-22. http://elibrary.ru/item.asp?id=23186356


3. Belsky Yu.P., Belskaya N.V., Danilets M.G., Trofimova E.S., Uchasova E.G., Ligacheva A.A., Agafonov V.I. Prospects for the pharmacological regulation of the activity of macrophages by modulating the intracellular signaling cascade. // Bulletin of the Russian Academy of Medical Sciences. ‑ 2009. ‑ Issue 11. ‑ P. 21-25. https://elibrary.ru/item.asp?id=13016890


4. Danilets M.G., Guriev A.M., Belskaya N.V., Belousov M.V., Belsky Yu.P., Uchasova E.G., Trofimova E.S., Ligacheva A.A., Akhmedzhanov R.R., Yusubov M.S., Agafonov V.I. Macrophages as a pharmacological target for regulation of the Th1/Th2 balance // Bulletin of Experimental Biology and Medicine. ‑ 2008. ‑ Suppl 2. ‑ P. 63-68. https://elibrary.ru/item.asp?id=19089929


5. Danilets M.G., Belskaya N.V., Belsky Yu.P., Uchasova E.G., Trofimova E.S., Ligacheva A.A., Gurev A.M., Belousov M.V., Akhmedzhanov R .R., Yusubov M.S., Agafonov V.I. Influence of water-soluble plant polysaccharides on NO-synthase and arginase of mouse macrophages // Bulletin of the Ural Medical Academic Science. ‑ 2009. – Vol. 25. – Issue 2. ‑ P. 49-50. http://elibrary.ru/item.asp?id=20162286


6. Danilets M.G., Belsky Yu.P., Belskaya N.V., Trofimova E.S., Uchasova E.G., Ligacheva A.A., Ivanova A.N., Kovalev V.V., Khotimchenko Yu.S. The effect of calcium alginate on Th1 and Th2 immune response // Biomedicine. ‑ 2011. ‑ Issue 3. ‑ P.125-132. http://elibrary.ru/item.asp?id=17048310


7. Belsky Yu.P., Belskaya N.V., Danilets M.G., Trofimova E.S., Kusmartsev S.A. Suppressive and antitumor activities of bone marrow cells and splenocytes of AKR mice during aging // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 1999. ‑ Vol. 127. – Issue 4. ‑ P. 410-412. https://elibrary.ru/item.asp?id=13323364


8. Danilets M.G., Belsky Yu.P., Belskaya N.V., Trofimova E.S., Uchasova E.G., Ligacheva A.A., Lopatina K.A., Safonova E.A., Guriev A. .M., Belousov M.V., Akhmedzhanov R.R., Yusubov M.S., Agafonov V.I. Immunological aspects of antitumor action of water-soluble polysaccharides of rhizomes of Acorus Calamus L. // Pacific Medical Journal. ‑ 2011. – Issue 1. ‑ P.44-47. http://elibrary.ru/item.asp?id=22631524


9. Ligacheva A.A., Ivanova A.N., Belsky Yu.P., Belskaya N.V., Trofimova E.S., Danilets M.G., Dygai A.M. Effect of NF-κB inhibitor aurothiomalate on local inflammation in experimental Th1- and Th2-type immune response. // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2012. ‑ Vol. 153. – Issue 4. ‑ P. 472-474. https://elibrary.ru/item.asp?id=20481743


10. Ligacheva A.A., Ivanova A.N., Belsky Y.P., Belska N.V., Trofimova E.S., Danilets M.G., Dygai A.M. Effect of IKK-2 inhibitor on local Th1 and Th2 type inflammation // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2013. Vol. ‑ 155. ‑ Issue 1. ‑ P. 52-55. https://elibrary.ru/item.asp?id=20440720


11. Zyuz'kov G.N., Danilets M.G., Ligacheva A.A., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Trofimova E.S., Minakova M.Y., Chaikovskii A.V., Agafonov V.I., Dygai A.M. Role of NF-κB-dependent signaling in the realization of growth potential of mesenchymal progenitor cells in vitro // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2013. ‑ Vol. 155. – Issue 6. ‑ P. 721-723. https://elibrary.ru/item.asp?id=21892672


12. Zyuz'kov G.N., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Losev E.A., Simanina E.V., Chaikovskiy A.V., Suslov N.I., Povet'Eva T.N., Krapivin A.V., Nesterova Y.V., Agafonov V.I., Minakova M.Y., Stavrova L.A., Danilets M.G., Ligacheva A.A., Trofimova E.S., Ivanova A.N., Goldberg V.E., Reikchart D.V., Dygai A.M. Mechanisms of napelline action stimulating the regeneration of hemopoietic tissue in cytostatic myelosuppression // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2013. Vol. ‑ 155. – Issue 4. ‑ P. 439-442. https://elibrary.ru/item.asp?id=20450721


13. Zyuz'kov G.N., Zhdanov V.V., Danilets M.G., Udut E.V., Miroshnichenko L.A., Ligacheva A.A., Simanina E.V., Trofimova E.S., Minakova M.Y., Chaikovskii A.V., Dygai A.M. Role of cAMP and IKK-2-dependent signaling in the realization of growth potential of mesenchymal progenitor cells // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2013. ‑ Vol. 156. ‑ Issue 2. ‑ P. 228-231. https://elibrary.ru/item.asp?id=21904765


14. Ligacheva A.A., Danilets M.G., Trofimova E.S., Belsky Y.P., Belska N.V., Zyuz'Kov G.N., Zhdanov V.V., Ivanova A.N., Dygai A.M., Guriev A.M., Belousov M.V., Yusubov M.S. Bulletin of Experimental Biology and Medicine. Signaling events during macrophage activation with betula pendula roth pectic polysaccharides // Bulletin of Experimental Biology and Medicine ‑ 2014. ‑ Vol. 156. ‑ Issue4. ‑ P. 465-469. https://elibrary.ru/item.asp?id=21873654


15. Zyuz'kov G.N., Danilets M.G., Ligacheva A.A., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Mova E.S.T., Minakova M.Y., Chaikovskii A.V., Agafonov V.I., Dygai A.M.Participation of PI3K, MAPK ERK1/2, and p38 in the realization of growth potential of mesenchymal precursor cells under in vitro conditions // Bulletin of Experimental Biology and Medicine (Springer Inc., New York, USA). ‑ 2014. ‑ Vol.156. ‑ Issue 4. ‑ P. 556-559. https://elibrary.ru/item.asp?id=21873792


16. Belsky Yu.P., Cherdyntseva N.V., Belskaya N.V., Danilets M.G., Trofimova E.S., Agafonov V.I., Kusmartsev S.A. Natural suppressor cells in normal and tumor growth. // Tomsk State University publishing house, 2007, 196 p. https://elibrary.ru/item.asp?id=21238760