Personalities

Alexander M. Dygai

Alexander M. Dygai, Doctor of Medical Sciences, Professor, Academician of RAS, honored worker of science of the Russian Federation, Scientific Supervisor of Goldberg Research Institute of Pharmacology and Regenerative Medicine of Tomsk National Research Medical Center of RAS, Deputy Academician- Secretary of Department of Medical Sciences of RAS - Head of Section of Biomedical Sciences.

Contact details

e-mail: dygai_am@pharmso.ru
tel.: +7(3822) 41-83-72
fax: +7(3822) 41-83-75

Brief Biography

Alexander Mikhailovich graduated from the Medical Faculty of Tomsk Medical Institute in 1975. After graduation, he studied in postgraduate school at the Department of Pathological Physiology of Tomsk Medical Institute, which he graduated in 1978, in the same year he successfully defended candidate dissertation. After graduation during the year he worked as a junior researcher at the Hematology Department of the Central Research Laboratory of Tomsk Medical Institute (1978-1979) and then as an assistant (1979-1983) and senior lecturer (1983-1984) at the Department of Pathophysiology. In May 1984 he was transferred to the Siberian branch of the Institute of Pharmacology of the USSR as a scientific secretary. In 1985 he was elected as the Head of the Laboratory of Pathophysiology and Experimental Therapy. In the same year he successfully defended his doctoral thesis "The Role of lymphoid tissue in the regulation of myelopoiesis under extreme impacts". In 1987 Alexander Mikhailovich was approved as the Deputy Director of Research Institute of Pharmacology of SB RAMS on scientific work, and in 2008 he was approved as its Director. Since March 24, 2016 he is Research supervisor of Goldberg Research Institute of Pharmacology and Regenerative Medicine.

February 19, 1994 A. M. Dygai was elected as a corresponding member, and in February 20, 2004 he was elected as a full member of the Russian Academy of Medical Sciences. In 2013 after the Russian Academy of Agricultural Sciences and the Russian Academy of Medical Sciences became incorporated into the RAS, he became an academician of the Russian Academy of Sciences, Department of Medical Sciences (Section of Biomedical Sciences).

In September 29, 2017 A. M. Dygai was elected as a Deputy Academician-Secretary of Department of Medical Sciences of RAS - Head of Section of Biomedical Sciences.

Research Interests

Scientific activity is devoted to the questions of pathophysiology, pharmacology and cell technologies. A. M. Dygai studied local and distant mechanisms of regulation of progenitor elements of different classes, including stem cells in norm and at pathology. On the model of the blood system the role of the individual components of tissue microenvironment and their interrelationships in the regulation of processes of tissue adaptogenesis in norm and under the action of pathogenic factors, the mechanisms of direct and mediated influence of the neuroendocrine system on the process of cellular self-renewal were investigated. For the first time in the world under his leadership created "Theory of regulation of hematopoiesis", "Concept of insufficiency and failure of deep reserve regeneration mechanisms", "Pharmacological strategy of regenerative medicine based on stimulation of endogenous stem cells by imitation of natural regulatory systems." A number of original methods of tissue culture, pathogenetically substantiated methods of correction of pathological conditions and new effective drugs of natural and synthetic origin, including those created using nanotechnology based on recombinant forms of cytokines and other biotechnological analogues of function regulators were developed.

Achievements, awards, and grants 

A.M. Dygai is the author of 777 published scientific papers, including 37 monographs and 174 inventor's certificate and patents. Under his leadership 21 doctoral and 44 candidate dissertations were prepared. He was awarded the prize of the Russian Academy of Medical Science named after A. A. Bogomolets (1993), prize of the Russian Academy of Medical Sciences for the best work in the field of fundamental medical research (1999), Russian Federation Government prize in the field of science and technology (2005), prize of Governor of Tomsk Region in education, science, health and culture (2010), international award Elsevier "SciVal / Scopus Аward Russia 2012" (2012) (for new, highly promising research area "Pharmacological Strategy for Regenerative Medicine"), the State prize of Novosibirsk Region for achievements in science and technology (2013) etc. In 2001, A. M. Dygai was awarded the honorary title of Honored worker of science of the Russian Federation, in 2013 he was awarded the medal of Honor.

The scale and quality of the scientific and practical significance of the works of A.M. Dygay and his students are confirmed by the grant of President of the Russian Federation received in 2008 to support the leading scientific schools of Russia, the competition of Russian Foundation for Basic Research won in 2008, as well as grants received under various Federal target programs. Thus, in the framework of the Federal target program "scientific and scientific-pedagogical personnel of innovative Russia" for 2009-2013 A. M. Dygai was the head of the State contract on the theme "Fundamental research in the field of genomic, post-genomic and cell technologies and the development of a new class of drugs based on regulators of the functions of progenitor cells for regenerative medicine" (2010-2012), in the framework of the Federal target program "Development of pharmaceutical and medical industry of the Russian Federation for the period until 2020 and further perspective" under his leadership State contract on the theme: "Preclinical studies of hepatoprotective based on immobilized hyaluronate-endo-β-N-acetylglucosaminidase"(2011 – 2013) was conducted, etc.

Alexander Mikhailovich Dygay is Deputy Academician-Secretary of Department of Medical Sciences of RAS -  Head of Section of Biomedical Sciences, a member of Joint Scientific Council of SB RAS on medical sciences, Presidium of the Russian society of pharmacologists, Co-Chairman of National society for regenerative medicine, Vice-President of the Russian society of pathophysiologists, member of International society of pathophysiologists, member of the editorial boards of the journals "Bulletin of experimental biology and medicine", "Cell technologies in biology and medicine", "Experimental and clinical pharmacology", "Pathological physiology and experimental therapy", etc.

Main Publications

1. Dygai A.M., Shakhov V.P. Role of intercellular interactions in hemopoiesis regulation. - Tomsk: Publishing house of TSU, 1989. – 224 p. –http://elibrary.ru/item.asp?id=24230665

2. Dygai A M., Klimenko N.A. Inflammation  and hemopoiesis. - Tomsk: Publishing house of TSU, 1992. – 274 p. – http://elibrary.ru/item.asp?id=24243581

3. Goldberg E.D., Dygai A.M., Shakhov V.P. Methods of tissue culture in hematology. - Tomsk: Publishing house of TSU, 1992.–272 p. –http://elibrary.ru/item.asp?id=21784585

4. Goldberg E.D., Dygai A.M., Khlusov I.A. Role of the autonomic nervous system in the regulation of hematopoiesis. - Tomsk: Publishing house of TSU, 1997. – 218 p. –http://elibrary.ru/item.asp?id=23689671

5. Goldberg E.D., Dygai A.M., Zhdanov V.V. Role of hemopoiesis inducing microenvironment in hemopoiesis regulation under cytostatic myelosuppressions. – Tomsk: STT, 1999. – 114 p. –http://elibrary.ru/download/76598794.pdf

6. Goldberg E.D., Dygai A. M., Sherstoboev E.Yu. Mechanisms of local regulation of hemopoiesis. – Tomsk: STT, 2000. -147 p. –http://elibrary.ru/download/27378671.pdf

7. Epstein O.I., Plotnikov M.B., Dygai A.M., Sergeeva S. A., Goldberg E.D., Petrov V.I., Voronina T.A., and Starostina M.V. Pharmacology of ultralow doses of antibodies to endogenous regulators of functions. – M.: Publishing house of Russian Academy of Medical Sciences, 2005. – 226 p. –http://elibrary.ru/item.asp?id=19530182

8. Goldberg E.D., Dygai A.M., Zhdanov V.V., Pershina O.V., Skurikhin E.G. Pharmacological regulation of blood system in experimental neurotic effects. - Tomsk: Publishing house of TSU, 2007. – 156 p. –http://elibrary.ru/item.asp?id=24260136

9. Dygai A.M., Zhdanov V.V. Granulocyte colony-stimulating factor. Pharmacological aspects. – M.: Publishing house of Russian Academy of medical Sciences, 2010. – 138 p. –http://elibrary.ru/item.asp?id=19555370

10. Dygai A.M., Artamonov A.V., Bekarev A.A., Zhdanov V.V., Zyuzkov G.N., Madonov P.G., Udut V.V. Nanotechnology in pharmacology. – M.: Publishing house of Russian Academy of medical Sciences, 2011. – 136 p. –http://elibrary.ru/item.asp?id=21928716

11. Dygai A.M.,  Zhdanov V.V. Theory of Hematopoiesis Control. – Springer International Publishing Switzerland, 2014. – SpringerBriefs in Cell Biology. – Vol. 5. – 93 p. – DOI:10.1007/978=3-319-08584-5-1. – http://www.springer.com/la/book/9783319085838

12. Dygai A.M., Skurikhin E.G., Ermakova N.N., Pershina O. V., Minakova, M.Y.  Role of amines in the regulation of hematopoietic stem and progenitor cells. – M.: Publishing house of RAMS, 2015. - 188 p – https://elibrary.ru/item.asp?id=23628615

13. Dygai A.M., Zyuz’kov G.N., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Khrichkova T.Yu., Minakova M.Yu., Madonov P.G. Specific Activity of Electron-Beam Synthesis Immobilized Hyaluronidase on G-CSF Induced Mobilization of Bone Marrow Progenitor Cells // Stem Cell Reviews and Reports. – 2013. – Vol. 9, № 2.   – P. 140-147 (DOI: 10.1007/s12015-012-9423-2). – https://link.springer.com/article/10.1007%2Fs12015-012-9423-2
    

14. Skurikhin E.G., Khmelevskaya E.S., Pershina O.V., Ermakova N.N., Krupin V.A., Ermolaeva L.A., Yakushina V.D., Reztsova A.M., Reztsova V.M., Stepanova I.E. and Dygai  A.M. Anti-fibrotic Effects of Reserpine on Lung Fibrosis: Stem Cells in the Pathogenesis of Pneumofibrosis // The Open Conference Proceedings Journal. –2013. –№ 4. – P. 31-46. - https://elibrary.ru/item.asp?id=26659671

15. Dygai A.M., Zyuz`kov G.N., Zhdanov V.V., Udut V.V., Artamonov A.V., Bekarev A.A., Minakova M.Yu. Immobilized Using Nanotechnology of Electron-Beam Synthesis Regulators of Progenitor Cells Functions: Remedies of New Generation for Regenerative Medicine // Recent Patents on Regenerative Medicine (Bentham Science Publishers). – 2013. – Vol. 3, № 2. – Р. 160-175. – http://www.eurekaselect.com/107560/article

16. Zyuz’kov G.N., Danilets M.G., Ligacheva A.A., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Trofimova E.S., Minakova M.Yu., Chaikovskii A.V., Agafonov V.I., Dygai A.M. Role of NF-κappa B-Dependent Signaling in the Realization of Growth Potential of Mesenchymal Progenitor Cells in Vitro // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2013. – Vol. 155, № 6. – P. 721-723. – https://link.springer.com/article/10.1007%2Fs10517-013-2236-8

17.  Zyuz’kov G.N., Maksimenko A.V., Zhdanov V.V., Udut E.V.,  Turashev A.D., Miroshnichenko L.A., Simanina E.V., Chaikovskiy A.V., Minakova M.Yu., Artamonov A.V., Bekarev A.A., Madonov P.G., Udut V.V., Dygai A.M. Specific Effects of Chondroitin Sulfate-Modified Hyaluronidase on the Function of Progenitor Cells // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2014. – V. 156. – Issue 4. – P. 544–547. – https://link.springer.com/article/10.1007%2Fs10517-014-2393-4

18.  Zyuz’kov G.N.,  Danilets M.G., Ligacheva A.A., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Trofimova E.S., Minakova M.Yu., Chaikovskiy A.V., Agafonov V.I., Dygai A.M.Participation of PI3K, MAPK ERK1/2, and p38 in the Realization of Growth Potential of Mesenchymal Precursor Cells under In Vitro Conditions  // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2014. – V. 156. – Issue 4. – P. 556–559. – https://link.springer.com/article/10.1007%2Fs10517-014-2395-2

19. Dygai A.M., Zhdanov V.V., L. A. Miroshnichenko,  Udut E.V.,  Zyuz’kov G.N., Simanina E.V., Chaikovskii A.V.,  Stavrova L.A.,  Trofimova E.S.,  Burmina Ya.V. Participation of Signaling Cascades in the Regulation of Erythropoiesis under Conditions of Cytostatic Treatment  // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2015. – V. 158. – Issue 3. – P. 304-307. – https://link.springer.com/article/10.1007%2Fs10517-015-2747-6

20. Zyuz’kov G.N.,  Suslov N.I.,  Losev E.A.,  Ermolaeva L.A.,  Zhdanov V.V.,  Udut E.V., Miroshnichenko L.A.,  Simanina E.V.,  Demkin V.P.,  Povet’eva T.N.,  Nesterova Yu.V., Udut V.V.,  Minakova M.Yu.,  Dygai A.M. Cerebroprotective and Regenerative Effects of Alkaloid Z77 under Conditions of Brain Ischemia //  Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2015. – V. 158. – Issue 3. – P. 352-355. – https://link.springer.com/article/10.1007%2Fs10517-015-2760-9

21. Dygai A.M. The pharmacological strategy of regenerative medicine // Herald of the Russian Academy of Sciences. – 2016. – Volume 86, Issue 3. – P. 193–196. –https://link.springer.com/article/10.1134%2FS1019331616030151

22. Skurikhin E.G., Pershina O.V., Reztsova A.M., Ermakova N.N., Khmelevskaya E.S., Krupin V.A., Stepanova I.E.,  Artamonov A.V., Bekarev A.A., Madonov P.G., Dygai A.M. Modulation of Bleomycin-Induced Lung Fibrosis by Pegylated Hyaluronidase and Dopamine Receptor Antagonist in Mice. // PLoS ONE. –2015. –10(4): e0125065. d DOI: 10.1371/journal.pone.0125065 –  https://elibrary.ru/item.asp?id=25335696

23. Dygai A.M.,  Chaikovskii A.V.,  Zhdanov V.V.,  Zyuz’kov G.N.,  Stavrova L.A.,  Udut V.V., Miroshnichenko L.A.,  Simanina E.V.,  Borovskaya T.G.,  Poluektova M.E.Responses of Spermatogenous Tissue and Mechanisms of Their Development Upon Cytostatic Exposure  // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2015. – V. 159. – Issue 6. – P. 743-746. – https://link.springer.com/article/10.1007%2Fs10517-015-3064-9

24. Zyuzkov G.N., Suslov N.I., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Minakova M.Y., Udut V.V., Dygay A.M. The development of pharmacological strategy of cell therapy and perspectives for the creation of highly selective drugs for regenerative medicine on the basis of alkaloids // Clin Exp Pharmacol. – 2015.– Vol. 5, N 4. – P. 103 (World congress on Pharmacology, July 20-22, 2015, Brisbane, Australia). DOI: 10.4172/2161-1459.S1.008

25. Скурихин Е.Г., Першина О.В., Крупин В.А., Резцова А.М., ЕрмаковаН.Н., Ермолаева Л.А., Хмелевская Е.С., Пахомова А.В., Пан Э.С., Мадонов П.Г., Шилова М.А., Дыгай А.М. Эффекты и механизм действия пегилированной гиалуронидазы у мышей C57BL/6 в условиях блеомицин-индуцированного фиброза легких // Патогенез.– 2015 – № 3. – C. 57-64. https://elibrary.ru/item.asp?id=26100623

26. Ligacheva A.A., Danilets M.G., Sherstoboev E. Yu., Zhdanov V.V., Guriev A. M., Belousov M.V., Yusubov M.S., Korzh A.P., Krivoshchekov S.V., Dygai A.M. Effects of Water-Soluble Polysaccharides with Different Chemical Structure, Isolated from Acorus calamus L. and Trifolium pratense L., on Nitric Oxide Production: A Screening Study   // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2016. – V. 160. – Issue 3. – P. 330-335. – https://link.springer.com/article/10.1007%2Fs10517-016-3163-2

27. Zhdanov V.V., Udut E.V., Sotnikova L.S., Burmina Ya.V., Miroshnichenko L.A., Simanina E.V., Polyakova T.Yu., Zyuz'kov G.N., Chaikovskii A.V., Stavrova L.A., Fedorova E.P., Dygai A.M. Pathogenetic Evaluation of Dysfunction in the Erythron System of Experimental Animals during Modeling of Iron Deficiency Anemia in the Gestation Period /// Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2016. – V. 160. – Issue 4. – P. 417-420. – https://link.springer.com/article/10.1007%2Fs10517-016-3185-9

28. Zyuz'kov G.N., Zhdanov V.V., Udut E.V.,  Miroshnichenko L.A., Simanina E.V., Polyakova T.Yu., Chaikovskii A.V., Stavrova L.A., Udut V.V., Agafonov V.I., Burmina Ya.V., Danilets M.G., Minakova M.Yu., Dygai A.M. Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2016. – V. 161. – Issue 2. – P. 224-227. – https://link.springer.com/article/10.1007%2Fs10517-016-3185-9

29. Zyuz'kov G.N., Amosova E.N., Chaikovskii A.V. Miroshnichenko L.A., Udut E.V., Rybalkina O.Yu., Zhdanov V.V., Udut V.V., Dygai A.M., Zueva E.P. Antitumor Effects of JAK3 Inhibitor on the Model of Transplantable Lewis Lung Carcinoma and Mechanisms of Their Development // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). – 2016.–V.161.–Issue 3.–P.367-370.– https://link.springer.com/article/10.1007%2Fs10517-016-3415-1

30. Miroshnichenko L.A., Zhdanov V.V., Udut E.V., Polyakova T.Y., Zyuz’kov G.N., Simanina E.V., Sherstoboev E.Y., Stavrova L.A., Agafonov V.I., Minakova M.Y., Chaikovskii, A.V., Dygai A.M. Role of NF-κB, PI3K, MAPK/ERK 1/2, and p38 in erythropoietin production by bone marrow nuclears under conditions of immobilization stress // Bulletin of Experimental Biology and Medicine. – 2017. – Volume 163, Issue 3. – P. 352-355. – https://link.springer.com/article/10.1007%2Fs10517-017-3802-2

31. Trofimova E.S., Zykova M.V., Ligacheva A.A., Sherstoboev E.Y., Zhdanov V.V., Belousov M.V., Yusubov M.S., Krivoshchekov S.V., Danilets M.G., Dygai A.M. Influence of humic acids extracted from peat by different methods on functional activity of macrophages in vitro // Bulletin of Experimental Biology and Medicine. – 2017. – Volume 162, Issue 6. – P. 741–745. – https://link.springer.com/article/10.1007%2Fs10517-017-3702-5

32. Goldberg V.E., Polyakova T.Yu., Popova N.O., Vysotskaya V.V., Simolina E.I., Belevich Yu.V., Tuzikova T.P., Goldberg A.V., Zhdanov V.V., Miroshnichenko L.A., Udut E.V., Simanina E.V., Dygai A.M., Zyuz’kov G.N. Assessment of erythroid and granulocytic hematopoietic lineages in patients with non-small-cell lung carcinoma // Bulletin of Experimental Biology and Medicine. – 2017. – Volume 163, Issue 4. – P. 469–474.– https://link.springer.com/article/10.1007%2Fs10517-017-3830-y