Personalities

Evgeny V. Denisov

PhD, DSc, Head of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC, Head of Single Cell Biology Laboratory, Institute of Molecular and Cellular Medicine, RUDN University

Contact details

e-mail: d_evgeniy@oncology.tomsk.ru
tel.: 8 (3822) 28-26-76 ext. 3375

Brief Biography

Work experience

2019 – Present: Head of Single Cell Biology Laboratory, Institute of Molecular and Cellular Medicine, RUDN University

2019 – Present: Head of the Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC
2015 – 2022: Assistant Professor, Department of Organic Chemistry, Tomsk State University
2011 – 2019: Senior Researcher, Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk NRMC
2014-2015: Senior Researcher, Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University
2010-2011: Probationer-Researcher, Institute of Biology and Biophysics, Tomsk State University
2009-2010: Senior Technician, Department of Cytology and Genetics, Tomsk State University
09-12.2009: Probationer-Researcher, Institute of Chemical Biology and Fundamental Medicine, SB RAS
2008-2011: Junior Researcher, Laboratory of Immunology, Cancer Research Institute, SB RAMS
2005 – 2008: Technician, Laboratory of Immunology, Cancer Research Institute, SB RAMS

Education

2011-2022: DSc in Oncology, Cancer Research Institute, Tomsk NRMC

2007-2010: PhD in Genetics, Tomsk State University
2005-2007: MSc in Biology, Tomsk State University
2001-2005: BSc in Biology, Tomsk State University

Research Interests

• Cancer cell plasticity

• Genetic determinants of cancer metastasis and recurrence

• Etiological factors and molecular mechanisms of early-onset cancer

• Personalized anticancer mRNA vaccines

• Next-generation sequencing in cancer diagnostics

Projects

More than 20 projects have been supported by Federal Target Program of Ministry of Science and Education of the Russian Federation, Russian Foundation for Basic Research (RFBR), Russian Science Foundation (RSF), The Russian President Grants, The Foundation for Assistance to Small Innovative Enterprises in Science and Technology, and OPTEK Company. At the present time, E.V. Denisov is a leader of three projects:

• “Molecular patterns of cancer invasive growth, metastasis and recurrence” (Laboratory basic research, 2022-2026)

• “Cell plasticity as a common program of embryogenesis and oncogenesis” (Tomsk NRMC project, 2024-2027)

• “Genetic predictors of cancer treatment efficacy” (National project, 2025-2027)

Awards

• The Certificate of Honor of the Ministry of Science and Higher Education of the Russian Federation (2023)

• The Commemorative Medal for Contribution to Science and Technology in Russia (2021)

• IASLC Developing Nation Travel Award (2019)

• Awards of the Tomsk Region Administration (2007, 2011, 2018)

• The Company of Biologist Bursary (2015)

• EACR Meeting Bursary Awards (2012, 2014)

• Travel Grant funded by Susan G. Komen for the Cure (2013)

• Travel grant of the 12th St. Gallen Breast Cancer Conference (2011)

• Fellowship of the 3rd Norwegian Cancer Symposium (2011)

• The Russian President Fellowship (2009-2010)

• CIMO Fellowship (2009)

• The Russian Government Fellowship (2008-2009)

• D.I. Mendeleev Fellowship (2008-2009)

• The Medal of the Ministry Science and Education of the Russian Federation (2008)

• Tomsk Mayor Fellowship (2006-2007)

Memberships

Publications

E.V. Denisov is an author of more than 300 publications (including 1 book, 3 book chapters, and 111 peer-reviewed papers), 10 Russian patents, 9 databases, and 1 know-how. 

The current list of publications: https://scholar.google.ru/citations?user=j-0koY0AAAAJ&hl

Selected publications

1.      Patysheva MR, Kolegova ES, Khozyainova AA, Prostakishina EA, Korobeynikov VY, Menyailo ME, Iamshchikov PS, Loos DM, Kovalev OI, Zavyalova MV, Fedorova IK, Kulbakin DE, Larionova IV, Polyakov AP, Yakovleva LP, Kropotov MA, Sukortseva NS, Lu Y, Jia L, Arora R, Choinzonov EL, Bose P, Denisov EV. Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics (2024). Scientific Reports 14:26255.

2.      Menyailo ME, Kopantseva EE, Khozyainova AA, Korobeynikova AA, Denisov EV. Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets (2024). Cancer Gene Therapy 10.1038/s41417-024-00856-7.

3.      Gerashchenko T, Skitchenko R, Korobeynikova A, Kuanysheva K, Khozyainova A, Vorobiev R, Rodionov E, Miller S, Topolnitsky E, Shefer N, Anisimenko M, Zhuikova L, Vashisth M, Pankova O, Perelmuter V, Rezapova V, Artomov M, Denisov E. Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer (2024). Gene, 920, 148507.

4.      Pershina AG, Efimova LV, Brikunova OY, Nevskaya KV, Sukhinina EV, Hmelevskaya ES, Demin AM, Naumenko VA, Malkeyeva D, Kiseleva E, Khozyainova AA, Menyailo ME, Denisov EV, Volegov AS, Uimin MA, Krasnov VP, Ogorodova LM. Nano-bio interaction of magnetic nanoparticles with cells in a tumor at the single-cell level (2024). Nano Today, 56, 102300.

5.      Perelmuter VM, Grigoryeva ES, Savelieva OE, Alifanov VV, Andruhova E S.,Zavyalova MV, Bragina OD, Garbukov EYu, Menyailo ME,Khozyainova AA, Denisov EV, Cherdyntseva NV, Tashireva LA. EpCAM-CD24+ circulating cells associated with poor prognosis in breast cancer patients (2024). Scientific Reports, 14, 12245.

6.      Lanshakov DA, Sukhareva EV, Bulygina VV, Khozyainova AA, Gerashchenko TS, Denisov EV, Kalinina TS. Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN) (2024). Scientific Reports, 14(1), 21856.

7.      Lobov A., Kuchur P., Khizhina A., Kotova A., Ivashkin A., Kostina D., Klausen P., Khokhlova E., Repkin E., Postnikova K., Perepletchikova D., Denisov E., Gerashchenko T., Tikhilov R., Bozhkova S., Sereda A., Karelkin V., Enukashvily N., Malashicheva A. Mesenchymal cells retain the specificity of embryonal origin during osteogenic differentiation (2024). Stem Cells, 42, 1, 76-89.

8.      Grigoryeva E., Tashireva L., Alifanov V., Savelieva O., Zavyalova M., Menyailo M., Khozyainova A., Denisov E.V., Bragina O., Popova N., Cherdyntseva N.V., Perelmuter V. Integrin-associated transcriptional characteristics of circulating tumor cells in breast cancer patients (2024). PeerJ, 12, e16678.

9.      Wang J, Xu H, Li S, Lin M, Lu Y, Liu K, Katanaev V, Denisov EV, Jia L. Long cruising aptamer-albumin nanobots intelligently capture and restrain circulating tumor cells (2023). Nano Today, 53, 102002

10. Volchkov E.V., Khozyainova A.A., Gurzhikhanova M.K., Larionova I.V., Matveev V.E., Evseev D.A., Ignatova A.K., Menyailo M.E., Venyov D.A., Vorobev R.S., Semchenkova A.A., Olshanskaya Yu.V., Denisov E.V., Maschan M.A. Potential value of high-throughput single-cell DNA sequencing of Juvenile myelomonocytic leukemia: report of two cases (2023). npj Systems Biology and Applications, 9, 41.

11. Gerashchenko TS, Schegoleva AA, Khozyainova AA, Choinzonov EL, Denisov EV (2023). Metastasis prevention: How to catch metastatic seeds. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1878, 3.

12. Khozyainova AA, Valyaeva AA, Arbatsky MS, Isaev SV, Iamshchikov PS, Volchkov EV, Sabirov MS, Zainullina VR, Chechekhin VI, Vorobev RS, Menyailo ME, Tyurin-Kuzmin PA, Denisov EV (2023). Complex Analysis of Single-Cell RNA Sequencing Data. Biochemistry Moscow, 88, 231-252.

13. Iamshchikov P, Larionova I, Gerashchenko T, Piankov D, Koshkin P, Korostelev S, Denisov E (2023). Comparison of the Illumina NextSeq 2000 and GeneMind Genolab M sequencing platforms for spatial transcriptomics. BMC Genomics, 24, 102.

14. Dayoub A, Fokin AI, Lomakina ME, James J, Plays M, Jacquin T, Novikov NM, Vorobyov RS, Schegoleva AA, Rysenkova KD, Gaboriaud J, Leonov SV, Denisov EV, Gautreau AM, Alexandrova AY (2023). Inactivation of PTEN and ZFHX3 in Mammary Epithelial Cells Alters Patterns of Collective Cell Migration. International Journal of Molecular Sciences, 24(1), 313.

15. Menyailo ME, Zainullina VR, Khozyainova AA, Tashireva LA, Zolotareva SY, Gerashchenko TS, Alifanov VV, Savelieva OE, Grigoryeva ES, Tarabanovskaya NA, Popova NO, Choinzonov EL, Cherdyntseva NV, Perelmuter VM, Denisov EV (2022). Heterogeneity of Circulating Epithelial Cells in Breast Cancer at Single-Cell Resolution: Identifying Tumor and Hybrid Cells. Advanced Biology, 2200206.

16. Semenova D, Zabirnyk A, Lobov A, Boyarskaya N, Kachanova O, Uspensky V, Zainullina B, Denisov E, Gerashchenko T, Kvitting J-PE, Kaljusto M-L, Thiede B, Kostareva A, Stensløkken K-O, Vaage J, Malashicheva A (2022). Multi-omics of in vitro aortic valve calcification. Frontiers in Cardiovascular Medicine, 9, 043165.

17. Yakushov S, Menyailo M, Denisov E, Karlina I, Zainullina V, Kirgizov K, Romantsova O, Timashev P, Ulasov I (2022). Identification of Factors Driving Doxorubicin-Resistant Ewing Tumor Cells to Survival. Cancers, 14(22), 5498.

18. Kolegova ES, Patysheva MR, Larionova IV, Fedorova IK, Kulbakin DE, Choinzonov EL, Denisov EV (2022). Early-onset oral cancer as a clinical entity: aetiology and pathogenesis. International Journal of Oral and Maxillofacial Surgery, S0901-5027(22)00141-2.

19. Schegoleva AA, Khozyainova AA, Gerashchenko TS, Zhuikova LD, Denisov EV (2022). Metastasis prevention: targeting causes and roots. Clinical Experimental Metastasis, 39, 505-519.

20. Larionova I, Rakina M, Ivanyuk E, Trushchuk Y, Chernyshova A, Denisov E (2022).  Radiotherapy resistance: identifying universal biomarkers for various human cancers. Journal of Cancer Research and Clinical Oncology, 148, 1015-1031.

21. Tretyakova M.S, Subbalakshmi AR, Menyailo ME, Jolly MK, Denisov EV (2022). Tumor Hybrid Cells: Nature and Biological Significance. Frontiers in Cell and Developmental Biology, 10, 814714.