Personalities

Evgeniya S. Grigoryeva

Evgeniya S. Grigoryeva, PhD, junior researcher of the Laboratory of Molecular Oncology and Immunology of Tomsk National Research Medical Center of the Russian Academy of Sciences.

Contact details

e-mail: grigoryeva.es@gmail.com
tel.: +7(3822)28-26-76 (additional 3340)

Brief Biography

Evgeniya Grigoryeva graduated from the Medico-biological Faculty of the Siberian State Medical University with a degree in Medical Biochemistry in 2008. In the same year she was elected to the position of junior researcher at the Laboratory of Immunology in Tomsk Research Institute of Oncology. In 2013 she successfully defended her dissertation on the topic "Identification of protein markers for the prediction of malignant tumors of the stomach" (on specialties: oncology and pathological physiology). Evgeniya Grigoryeva successfully completed an advanced training course in the program «Flow cytometry in immunology and biotechnology. Practical course» on the basis of St. Petersburg State University.

Research Interests

Evgeniya Grigoryeva is a co-author of 18 scientific articles, 2 patents for inventions and 1 database. Evgeniya’s main research interests are focused on the search for new proteomic markers for diagnosis and prognosis of the clinical course of tumors.

Achievements, awards, and grants 

Grigoryeva E.S. constantly improving her professional skills, attending conferences, seminars, schools and trainings. Evgeniya Grigoryeva took part in the following grants:

Russian Foundation for Basic Research: 2D proteomic analysis of human stomach cancer tissues: identification of proteins involved in the mechanisms of oncogenesis and their use for diagnosis and prognosis of the disease (09 04 99072-р _офи) (2009–2010); The role of androgen-induced transmembrane prostate protein (PMEPA1) in the carcinogenesis of the epithelium of the stomach(14-04- 31500 мол_а) (2013-2014); Molecular markers of progression/inhibition of morphological changes in the bronchial epithelium for predicting the course of the precancerous process and the probability of developing squamous cell lung cancer (17-29-06002) (2017-2019).

The federal special-purpose program «Scientific and scientific-pedagogical staff of innovative Russia»: Identification of protein markers for diagnosis and prediction of gastric cancer (02.740.11.0769) (2009–2013); «Development of molecular signatures of autoantibodies to DNA adducts for early diagnosis of lung cancer» (№14.575.21.0064) (2015-2016).

International Science and Technology Center: «2D proteomics of stomach cancer: selection of serum markers for diagnosis and prediction of the disease» (2009–2011).

The Russian Science Foundation «Molecular mechanism of the second type macrophages regulatory proteins in the formation of tumor microenvironment and tumor progression» (14-15-00350).

Main Publications

1. Development of Novel Monoclonal Antibodies for Evaluation of Transmembrane Prostate Androgen-Induced Protein 1 (TMEPAI) Expression Patterns in Gastric Cancer.Karbyshev MS, Grigoryeva ES, Volkomorov VV, Kremmer E, Huber, Mitrofanova IV, Kaigorodova EV, Zavyalova MV, Kzhyshkowska JG, Cherdyntseva NV, Choynzonov EL Pathol Oncol Res. 2017 Jun 5. doi:10.1007/s12253-017- 0247-x. [Epub ahead of print]. (Impact Factor 1,7).

2. Expression of Cyclophilin A in Gastric Adenocarcinoma Patients and Its Inverse Association with Local Relapses and Distant Metastasis. Grigoryeva, E.S. , Cherdyntseva, N.V., Karbyshev, M.S., Volkomorov, V.V., Stepanov, I.V., Zavyalova, M.V., Perelmuter, V.M., Buldakov, M.A., Afanasjev, S.G., Tuzikov, S.A., Bukurova, Y.A., Lisitsyn, N.A., Beresten, S.F. Pathology and Oncology Research, 2013, P. 1-7 . (Impact Factor 1,7).
   

3. Identification of proteins overexpressed in malignant gastric tumors: Comparison of results obtained by 2DE and bioinformatic search. Grigorieva, E.S., Bukurova, Y.A., Krasnov, G.S., Afanasjev, S.G., Cherdyntseva, N.V., Tuzikov, S.A., Choinzonov, E.L.ac, Karpov, V.L., Lisitsyn, N.A., Beresten, S.F. Molecular Biology. Volume 45, Issue 4, 2011, P. 680-685. (Impact Factor 0,637).

4. Estimation of the efficiency of 2D analysis and bioinformatics search in identification of protein markers for colon tumors. Bukurova, Y.A., Khankin, S.L., Krasnov, G.S., Grigoryeva, E.S., Mashkova, T.D., Lisitsyn, N.A., Karpov, V.L., Beresten', S.F. Molecular Biology. Volume 44, Issue 2, 2010, P. 334-340. (Impact Factor 0,637).

5. Comparison of 2D analysis and bioinformatics search efficiency for colon cancer marker identification. Bukurova, I.A., Khankin, S.L., Krasnov, G.S., Grigor'eva, E.S., Mashkova, T.D., Lisitsin, N.A., Karpov, V.L., Beresten', S.F. Molekuliarnaia biologiia Volume 44, Issue 2, 2010, P. 375-381.(Impact Factor 0,637).

6. Search for potential gastric cancer markers using miRNA databases and gene expression analysis. Volkomorov, V., Grigoryeva, E., Krasnov, G., Litviakov, N., Tsyganov, M., Karbyshev, M., Zavyalova, M., Afanasóev, S., Cherdyntseva, N., Lisitsyn, N., Beresten, S. Experimental Oncology. Volume 35, Issue 1, 2013.

7. Identification of gastric adenocarcinoma markers based on bioinformatic search and analysis of gene expression. Volkomorov V.V., Grigoryeva E.S., Krasnov G.V., Litvyakov N.V., Lisitsyn N.A., Voevoda M.I., Belkovec A.V., Afanas’ev S.G., Cherdytseva N.V. Успехи молекулярной онкологии. 2017. Т. 4. № 1. С. 40-45.

8. Patent №2493568 Russian Federation, МПК7 G01N33/53. Method for predicting hematogenous metastasis in a diffuse type of gastric cancer. M.V. Zavyalova, V.M. Perelmuter, I.V. Stepanov, N.V. Cherdytseva, N.V. Litvyakov, S.V. Vtorushin, S.G. Afanas’ev, A.V. Avgustinovich, O.V. Savenkova, E.S. Grigoryeva, C.F. Beresten, V.V. Volkomorov. – № 2012129593/15; Statement - 12.07.12; Publ. - 20.09.13, Bul. № 26 – 6 p.
   

9. Patent №2470308 Russian Federation, МПК G01N33/53. Method for predicting hematogenous metastasis in a intestinal type of gastric cancer M.V. Zavyalova, V.M. Perelmuter, I.V. Stepanov, S.V. Vtorushin, N.V. Cherdytseva, N.V. Litvyakov, S.G. Afanas’ev, A.V. Avgustinovich, O.V. Savenkova, E.S. Grigoryeva, C.F. Beresten. - № 2011134537/15; Statement - 17.08.2011, Publ. - 20.12.2012.

10. Database of clinical and pathological parameters of patients diagnosed with gastric cancer. Certificate of state registration of the database №2012620818 from 22 august 2012. N.V. Cherdytseva, E.S. Grigoryeva, S.G. Afanas’ev, A.I. Ivanova, N.S. Rodycheva, V.M. Perelmuter, S.V. Vtorushin, M.V. Zavyalova, I.V. Stepanov, P.A. Gervas, V.A. Bychkov.