Denis E. Kulbakin
M.D., Ph.D., D.Sc., Senior Researcher, Department of Head and Neck Tumors, Cancer Research Institute, Tomsk National Research Medical Center.Contact details
E-mail: kulbakin_d@mail.ru
Tel: +7 (3822) 41-80-62
Brief biography
Denis E. Kulbakin graduated with honors from Siberian Medical University in 2008. From 2008 to 2010 he completed a residency training at the Head and Neck Cancer Department of the Cancer Research Institute of the Tomsk Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences (currently Cancer Research Institute of Tomsk NRMS). In 2013, he defended a doctoral thesis titled «Organ-preserving surgery after radical radiation therapy in patients with recurrent laryngeal cancer» for a Ph.D. degree. From 2016 to 2017, Dr. Kulbakin completed an internship in surgery at Siberian State Medical University of the Ministry of Health of the Russian Federation. Since 2015, he has been a Senior Researcher of the Department of Head and Neck Cancer of Cancer Research Institute of Tomsk NRMS. In 2021, Dr. Kulbakin defended a doctoral thesis titled "Reconstructive surgery in the combined modality treatment of patients with head and neck tumors. Improving the technique, researching new reconstructive materials" for a D.Sc. degree.
Dr. Kulbakin is an author of 10 patents of inventions in the field of organ-preserving surgery for laryngeal cancer, reconstruction of the maxillofacial region and non-invasive diagnostics of tumors of the upper respiratory tract.
He is an active member of the Russian Head and Neck Cancer Society, the Russian Head and Neck Cancer Partnership, the European Head and Neck Cancer Society, the American Head and Neck Cancer Society.
Internships at the workplace in the world's leading clinics: Federal State Institution "Clinical Center of Otorhinolaryngology", Moscow, 2011, 2014; Karolinska Clinic, Stockholm, Sweden, 2011; Department of Head and Neck Surgery / Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences and Research Centre, Kochi, India, 2013; Department of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, 2014 and 2015; Department of Plastic Surgery, Asan Medical Center, Seoul, South Korea, 2016; Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA, 2017; Department of Head and Neck Surgery, University of Chicago and University of Chicago Medicine, Chicago, USA, 2017.
Research interests
Organ-preserving surgery for head and neck tumors using microsurgical reconstruction
Development of new implants for reconstructive surgery in the maxillofacial region.
Microlaryngoscopy and endoscopic resections of the larynx.
Development of non-invasive methods for cancer detection.
Achievements, awards, and grants
Denis E. Kulbakin is a laureate of the Tomsk Region in the field of Education, Science and Health (2012). He received Honorary Diploma of the Department of Health of the Tomsk Region in 2019, Tomsk Region Administration Award in the field of Science and Education in 2021.
Denis E. Kulbakin has been Investigator for the projects titles:
«Biodegradable and non-biodegradable medical devices for the replacement and restoration of large bone defects and soft tissue reconstruction» supported by RFBR grant № 020-15-2021-010 (2021-2026)
«Development of a multisensor complex for cancer molecular diagnostics based on highly sensitive nanomatrix gas sensors and methods of neural network data integration" supported by the Federal Target Program government contact № 05.604.21.0221 (2019-2020)
«Development of composite implants for reconstructive surgery in the craniofacial region in cancer patients» supported by the Federal Target Program government contact № №14.578.21.0031 (2014-2016)
«Development of osteostimulating implants based on hybrid technologies for modifying their surface and computer simulation of drug release for personalized medicine in polytrauma and oncology» supported by the Federal Target Program government contact №14.575.21.0140 (2017)
Denis E. Kulbakin has been Principal Investigator for the projects titles:
«Development of a method for the reconstruction of defects in the maxillofacial region using implants from bioactive ceramics in cancer patients» supported by the grant of the Tomsk Region Administration №126 (2016)
Main publications
1. E.S. Kolegova, M.R. Patysheva, I.V. Larionova, I.K. Fedorova, D.E. Kulbakin, E.L. Choinzonov, E.V. Denisov. Early-onset oral cancer as a clinical entity: aetiology and pathogenesis. Int. J. Oral Maxillofac. Surg. 2021; xx: 1–13.
2. Solution blow spinning of PLLA/Hydroxyapatite composite scaffolds for bone tissue engineering / Arnold Popkov, Denis Kulbakin, Dmitry Popkov, Elena Gorbach, Natalia Kononovich, Nadezhda Danilenko, Ksenia Stankevich, Evgeny Choynzonov, Alexander Zheravin, Igor Khlusov, Ludmila Bondar, Vladimir Perelmuter, Evgeny Bolbasov, Sergei Tverdokhlebov // Biomedical Materials. – 2021. – Jul 20. – Vol. 16, N 5. – doi: 10.1088/1748-605X/ac11ca
3. Characterization and Determination of the Biocompatibility of Porous Polytetrafluoroethylene Membranes Fabricated via Electrospinning / I. Kolesnik, T. Tverdokhlebova, N. Danilenko, E. Plotnikov, D. Kulbakin, A. Zheravin, V. Bouznik, E. Bolbasov // Journal of Fluorine Chemistry. – June 2021. – Vol. 246, N 109798.
4. Postoperative complications of reconstructive surgeries in head and neck cancer patients / D.E. Kulbakin, E.L. Choinzonov, M.R. Mukhamedov, L.A. Kononova, N.M. Khavkin, V.A. Alekseev, E.N. Menkova // Siberian Journal of Oncology. - 2021. - V. 20, No. 1. - P. 53–61.
5. Vladimir I. Chernov, Evgeniy L. Choynzonov, Denis E. Kulbakin, Ekaterina N. Menkova, Elena V. Obkhodskaya, Artem V. Obkhodskiy, Aleksandr S. Popov, Evgeniy O. Rodionov , Victor I. Sachkov, Anna S. Sachkova. Non-Invasive Diagnosis of Malignancies Based on the Analysis of Markers in Exhaled Air. Diagnostics 2020, 10, 934; doi:10.3390/diagnostics10110934
6. Chernov V. I. , Choynzonov E. L., Kulbakin D. E., Obkhodskaya E. V., Obkhodskiy A. V., Popov A. S., Sachkov V. I., Sachkova A. S. Cancer Diagnosis by Neural Network Analysis of Data from Semiconductor Sensors. Diagnostics. 2020; 10, 677. doi:10.3390/diagnostics10090677. URL: https://www.mdpi.com/2075-4418/10/9/677
7. Bioimplants as a new trend in reconstructive surgery / D.E. Kulbakin, D.Yu. Egorova, D.I. Azovsky // Problems in Oncology. - 2020. - V. 66, No. 3. - P. 228–232.
8. Interaction of composite bioreservable implants manufactured by aerodynamic molding with tissues / D.E. Kulbakin, E.L. Choynzonov, N.V. Cherdyntseva, E.N. Bolbasov, V.A. Svetlichny, I.N. Lapin, S.I. Tverdokhlebov, A.A. Zheravin, L.N. Bondar, V.M. Perelmuter // Siberian Scientific Medical Journal. - 2019. - V. 39, No. 5. - P. 92–101.
9. The choice of reconstructive material in the restoration of bone defects in the maxillofacial region in cancer patients / D.E. Kulbakin, E.L. Choinzonov, S.P. Buyakova, S.N. Kulkov, M.R. Mukhamedov, V.I. Chernov, A.S. Buyakov // Head and neck. - 2019. - No. 2. - P. 64–68.
10. The role of reconstructive surgery in surgical treatment of patients with oral cavity cancer / E.L. Choynzonov, D.E. Kulbakin, M.R. Mukhamedov // ENI Trans-Baikal Medical Bulletin. - 2019. - No. 2. - P. 105–111.
11. Reconstructive surgery in patients with oral cavity cancer/ D.E. Kulbakin, E.L. Choynzonov, M.R. Mukhamedov, E.Yu. Garbukov, R.V. Vasiliev, A.A. Shiyanova // Problems of Oncology. - 2018. - T. 64, No. 5. - P. 602–606.12. Kulbakin D.E., Choynzonov E.L., Mukhamedov M.R., Garbukov E.Yu., Shtin V.I., Khavkin N.M., Vasiliev R.V. Reconstructive surgery in the combined modality treatment of patients with locally advanced head and neck cancer. Problems in Oncology. 2017; 6. V 63. 862-866 https://elibrary.ru/item.asp?id=30793505
13. Kulbakin D.E., Choynzonov E.L., Kulkov S.N., Buyakova S.P., Chernov V.I., Mukhamedov M.R., Buyakov A.S. The technique of the maxillofacial region reconstruction using individual implants from bioactive ceramics. Head and Neck Tumors. 2017; 4(7) 29-34. DOI: http://dx.doi.org/10.17650/2222-1468-2017-7-4-29-34 http://ogsh.abvpress.ru/jour/article/view/306/300
14. Denis Kulbakin, Timofey Chekalkin, Marat Muhamedov, Evgeniy Choynzonov, Ji-hoon Kang, Seung-baik Kang, Victor Gunthera. Sparing Surgery for the Successful Treatment of Thyroid Papillary Carcinoma Invading the Trachea: A Case Report // Case Rep Oncol 2016;9:772–780. DOI: 10.1159/000452790 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156893/
15. Muhamedov, M., Kulbakin, D., Gunther, V., Choynzonov, E.,Chekalkin, T., Hodorenko, V. J.. Sparing surgery with the use of tini-based endografts in larynx cancer patients // Surg. Oncol., 111(2015): 231–236. http://ijcto.org/index.php/IJCTO/article/view/ijcto.34.04
16. E.G. Nikitina, O.V. Cheremisina, V.A. Bychkov, D.E. Kulbakin, E.L. Choynzonov, V.N. Stegniy, N.V. Litvyakov. MicroRNA expression in tumor tissue in patients with laryngeal cancer // Siberian Journal of Oncology. 2015. No. 2. P. 46–52 https://elibrary.ru/item.asp?id=23417718Е.
17. Choynzonov E.L., Novikov V.A., Mukhamedov M.R., Shishkin D.A., Chizhevskaya S.Yu., Syrkashev V.A., Shtin V.I., Kulbakin D.E. Combined modality treatment including reconstructive surgery in patients with head and neck cancer // Problems in Oncology. 2015. V. 61. No. 4. P. 602-606. https://elibrary.ru/item.asp?id=23852477
18. Choynzonov E. L., Spirina L. V., Kondakova I. V., Chizhevskaya S. Yu., Shishkin D. A., Kulbakin D. E. The role of intracellular proteinases in the regulation of the expression of transcription factors HIF-1α, NF -kB and vascular growth factor in lymphogenous metastasis of squamous cell carcinomas of the head and neck // Bulletin of SO RAMS. - 2012. - Volume 32, No. 6. - P.15-21. http://sibmed.net/article/98/3_6_2012.pdf
19. Spirina Liudmila V., Kondakova Irina V., Choynzonov Evgeny L., Chigevskaya Svetlana Y., Shishkin Dmitry A., Kulbakin Denis Y. Expression of vascular endothelial growth factor and transcription factors HIF-1, NF-kB expression in squamous cell carcinoma of head and neck; association with proteasome and calpain activities // J Cancer Res Clin Oncol (2013) 139:625–633 DOI 10.1007/s00432-012-1366-0
20. M. R. Mukhamedov, O. V. Cheremisina, E. Ts. Choynzonov, D. E. Kulbakin, L. N. Balatskaya, N. V. Vasiliev, V.E. Gyunter. A modern view on an integrated approach to the diagnosis, treatment and rehabilitation of patients with laryngeal cancer // Russian Otorhinolaryngology. No. 3 (58). 2012. P 78-84. https://elibrary.ru/item.asp?id=17902530