Research projects

Grants

1. Russian Foundation for Basic Research No. 18-29-09046 “Ethnospecific mutations associated with breast cancer in the indigenous population of Siberia and Russian Far East”, 2018-2021.

Publications

1. Cherdyntseva N, Gervas P, Voropaeva E, Denisov E, Pisareva L, Malinovskaya E, Maksimov V, Voevoda M, Perinov D, Panferova Y, Cherdyntsev E, Choynzonov E. New variants in the BRCA1 gene in Buryat Mongol breast cancer patients: Report from two families // Cancer Biomark. – 2017, 18(3). – P. 291-296. - doi: 10.3233/CBM-161649. – URL: https://content.iospress.com/articles/cancer-biomarkers/cbm161649
2. Gervas, P., Klyuch, B., Denisov, E., Kiselev, A., Molokov, A., Pisareva, L., Malinovskaya, E., Choynzonov, E., Cherdyntseva, N. New germline BRCA2 gene variant in the tuvinian mongol breast cancer patients // Molecular Biology Reports 2019. – doi: 10.1007/s11033-019-04928-y. – URL: https://link.springer.com/content/pdf/10.1007%2Fs11033-019-04928-y.pdf

Grants

1. Russian Foundation for Basic Research No. 18-515-16002 “Genetic alterations involved in tumor cell invasion and their role in breast cancer development”, 2018-2022.
2. Russian Foundation for Basic Research No. 18-515-16001 «Patterns of expression of new tumor suppressor LIMCH1 in breast cancer: an association with disease progression», 2018-2020.
3. Russian Science Foundation No. 14-15-00318 “Clonal invasive architectonics of tumor as a new study platform for the development of predictive and prognostic markers of breast cancer”, 2014-2016.
4. Russian Foundation for Basic Research No. 16-34-00415/16 “Defining the role of innate lymphoid cells in the formation of invasive properties invasive carcinoma not specific type”, 2016-2017.

Publications

1. Denisov EV, Gerashchenko TS, Zavyalova MV, Litviakov NV, Tsyganov MM, Kaigorodova EV, Slonimskaya EM, Kzhyshkowska J, Cherdyntseva NV, Perelmuter VM. Invasive and drug resistant expression profile of different morphological structures of breast tumors. // Neoplasma. 2015 Vol.62, No.3, p.405-411 . – doi: 10.4149/neo_2015_041. – URL: http://www.elis.sk/download_file.php?product_id=4178&session_id=kgbff8kngalplc1rqrou89rjb4
2. Denisov E.V., Gerashchenko T.S., Cherdyntseva N.V., Zavyalova M.V., Skryabin N.A., Vasilyev S.A., Lebedev I.N., Perelmuter V.M. Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: A report of one case // Journal of clinical pathology . – 2015. - doi: 10.1136/jclinpath-2015-203009. – URL: https://jcp.bmj.com/content/jclinpath/68/9/758.full.pdf #14-15-00318
3. Tashireva L. A., Denisov E. V., Savelieva O. E., Geraschenko T. S., Zavyalova M. V., Perelmuter V. M. Heterogeneity of premetastatic niche gene expression in breast cancer cells // Biopolym. Cell. 2015; 31(6):429-435. – doi: http://dx.doi.org/10.7124/bc.000900. - URL: https://pdfs.semanticscholar.org/71ca/40a1e65c0fcd068973232656228d8e6099de.pdf?_ga=2.82564767.881993767.1567411040-390908554.1567411040
4. Zavyalova M., Vtorushin S.V., Telegina N., Krakhmal N., Savelieva O., Tashireva L., Bragina O., Denisov E.V., Kaigorodova E.V., Slonimskaya E., Choynzonov E.L., Perelmuter V.M. Clinicopathological features of nonspecific invasive breast cancer according to its molecular subtypes // Exp Oncol 2016  38, 2, 122–127. – URL: http://exp-oncology.com.ua/wp/wp-content/uploads/2016/06/2266.pdf?upload=
5. Tashireva LA, Denisov EV, Gerashchenko TS, Pautova DN, Buldakov MA, Zavyalova MV, Kzhyshkowska J, Cherdyntseva NV, Perelmuter VM. Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis // Immunobiology. 2017 Apr;222(4):631-640.- doi: 10.1016/j.imbio.2016.11.012. – URL: https://www.sciencedirect.com/science/article/pii/S0171298516304478?via%3Dihub
6. Denisov E.V, Skryabin N.A, Gerashchenko T.S, Tashireva L.A, Wilhelm J, Buldakov M.A, Sleptcov A.A, Lebedev I.N, Vtorushin S.V, Zavyalova M.V, Cherdyntseva N.V, Perelmuter V.M Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+CD24- stemness // Oncotarget. – 2017 Sep 5; 8(37): 61163–61180. – doi: 10.18632/oncotarget.18022. – URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617414/
7. Gerashchenko TS, Denisov EV, Novikov NM, Tashireva LA, Kaigorodova EV, Savelieva OE, Zavyalova MV, Cherdyntseva NV, Perelmuter VM. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles.// Exp Oncol. – 2018. - Vol.40, № 3. – P. 228-234. – URL: http://exp-oncology.com.ua/wp/wp-content/uploads/2018/09/2470.pdf?upload=
8. Denisov E.V., Perelmuter V.M. A fixed partial EMT triggers carcinogenesis, whereas asymmetrical division of hybrid EMT cells drives cancer progression. Hepatology 2018. - doi: 10.1002/hep.29784. – URL: https://aasldpubs.onlinelibrary.wiley.com/doi/epdf/10.1002/hep.29784
9. Planchon D., Rios Morris E., Genest M., Comunale F., Vacher S., Bièche I., Denisov E.V., Tashireva L.A., Perelmuter V.M., Linder S., Chavrier P., Bodin S., Gauthier-Rouvière C. MT1-MMP targeting to endolysosomes is mediated by upregulation of flotillins // J Cell Sci. 2018 Sep 5;131(17). pii: jcs218925. - doi: 10.1242/jcs.218925. – URL: https://jcs.biologists.org/content/joces/131/17/jcs218925.full.pdf
10. Gerashchenko T.S, Novikov N.M, Krakhmal N.V, Zolotaryova S.Y, Zavyalova M.V, Cherdyntseva N.V, Denisov E.V, Perelmuter V.M. Markers of Cancer Cell Invasion: Are They Good Enough? J Clin Med. 2019;8(8). pii: E1092. - doi: 10.3390/jcm8081092. – URL: https://www.mdpi.com/2077-0383/8/8/1092/htm

Grants

1. No. MD-273.2017.7 “Development of the algorithm for predicting lung cancer recurrences and metastases based on the panel of proinflammatory status molecular markers”, 2017-2018.
2. Russian Foundation for Basic Research No. 14-04-01881 “Novel approach for tumor "molecular portrait" generation: circulating blood microRNA analysis in lung cancer”, 2014-2016.

Publications

1. Grigoryeva ES, Kokova DA, Gratchev AN, Cherdyntsev ES, Buldakov MA, Kzhyshkowska JG, Cherdyntseva NV. Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives // Exp Oncol. 2015 Mar;37(1):5-12. – URL: http://exp-oncology.com.ua/wp/wp-content/uploads/2015/03/5-12.pdf?upload=
2. Gervas P, Ivanova A, Vasiliev N, Ananina O, Zharkova O, Rogovieva O, Verzhbitskaya N, Didichuk I, Cheremisina O, Popova N, Goldberg V, Cherdyntsev E, Choynzonov E, Cherdyntseva N. Frequency of EGFR Mutations in Non-small Cell Lung Cancer Patients: Screening Data from West Siberia. // Asian Pac J Cancer Prev. 2015;16(2):689-92. - doi: 10.7314/apjcp.2015.16.2.689.
3. Ponomaryova AA, Morozkin ES, Rykova EY, Zaporozhchenko IA, Skvortsova TE, Dobrodeev АY, Zavyalov AA, Tuzikov SA, Vlassov VV,Cherdyntseva NV, Laktionov PP, Choinzonov EL. Dynamic changes in circulating mirna levels in response to antitumor therapy of lung cancer // Exp Lung Res. -  2016. Mar 17:1-8. – doi: https://doi.org/10.3109/01902148.2016.1155245. – URL: https://www.tandfonline.com/doi/full/10.3109/01902148.2016.1155245
4. Gainetdinov IV, Kapitskaya KY, Rykova EY, Ponomaryova AA, Cherdyntseva NV, Vlassov VV, Laktionov PP, Azhikina TL. Hypomethylation of human-specific family of LINE-1 retrotransposons in circulating DNA of lung cancer patients // Lung Cancer. 2016 Sep;99:127-30. - doi: 10.1016/J.Lungcan.2016.07.005. - https://www.sciencedirect.com/science/article/abs/pii/S0169500216304056?via%3Dihub
5. Zaporozhchenko IA, Morozkin ES, Skvortsova TE, Ponomaryova AA, Rykova EY, Cherdyntseva NV, Polovnikov ES, Pashkovskaya OA, Pokushalov EA, Vlassov VV, Laktionov PP. Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer // PLoS One. 2016 Oct 21;11(10):e0165261. doi: 10.1371/journal.pone.0165261. – URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165261
6. Zaporozhchenko IA, Morozkin ES, Ponomaryova AA, Rykova EY, Cherdyntseva NV, Zheravin AA, Pashkovskaya OA, Pokushalov EA, Vlassov VV, Laktionov PP. Profiling of 179 miRNA Expression in Blood Plasma of Lung Cancer Patients and Cancer-Free Individuals // Sci Rep. 2018 Apr 20;8(1):6348. - doi: 10.1038/s41598-018-24769-2. – URL: https://www.nature.com/articles/s41598-018-24769-2.pdf
7. Pankova, O.V., Denisov, E.V., Ponomaryova, A.A., Gerashchenko, T.S., Tuzikov, S.A., Perelmuter, V.M. Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium. Tumor Biology 2016;37(3), pp. 3599-3607. doi: 10.1007/s13277-015-4196-2. – URL: https://link.springer.com/content/pdf/10.1007%2Fs13277-015-4196-2.pdf

Grants

1. Russian Science Foundation No. 19-75-30016 “New strategy for the prediction and prevention of distant metastasis based on the detection of circulating metastasis-initiating and niche-forming cells and their specific targets”, 2019-2022.
2. Russian Science Foundation No. №16-15-10221 “Patterns of recruitment of different tumor cell subpopulations including cancer stem cells and cells in EMT state as a platform for the prognosis of metastasis”, 2016-2018.
3. No. MD-544.2018.7 “Development of new minimally invasive approaches for cancer prediction (breast and ovarian cancer) based on the evaluation of various populations of circulating tumor cells as liquid biopsy markers”, 2018-2019.
4. No. SP-784.2015.4 “Prognostic value of heterogeneity of peritumoral inflammatory infiltrate of invasive breast cancer component”, 2015-2017.

Publications

1. Cherdyntseva NV, Litviakov NV, Denisov EV, Gervas PA, Cherdyntsev ES. Circulating tumor cells in breast cancer: functional heterogeneity, pathogenetic and clinical aspects // Exp Oncol. – 2017. - Mar;39(1):2-11. – URL: http://exp-oncology.com.ua/wp/wp-content/uploads/2017/03/2340.pdf?upload=
2. Kaigorodova E. V., Tarabanovskaya N. A., Staheeva M. N., Savelieva O. E., Tashireva L. A., Denisov E. V., Perelmuter V. M. Effect of small and radical surgical injury on the level of different populations of circulating tumor cells in the blood of breast cancer patients // Neoplasma. – 2017. – V. 64, 3. - 437-443. - doi:10.4149/neo_2017_315. – URL: http://www.elis.sk/download_file.php?product_id=5134&session_id=kgbff8kngalplc1rqrou89rjb4
3. Kaigorodova E.V., Savelieva O.E., Tashireva L.A., Tarabanovskaya N.A., Simolina E.I., Denisov E.V., Slonimskaya E.M., Choynzonov E.L., Perelmuter V.M. Heterogeneity of circulating tumor cells in neoadjuvant chemotherapy of breast cancer // Molecules 2018;23(4):727. – doi: 10.3390/molecules23040727. – URL: https://www.mdpi.com/1420-3049/23/4/727/htm
4. Perelmuter V.M, Tashireva L.A, Savelieva O.E, Denisov E.V, Kaigorodova E.V, Zavyalova M.V, Cherdyntseva N.V. Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment // Breast Cancer (Dove Med Press). 2019 Jul 5;11:209-219. - doi: 10.2147/BCTT.S175161. eCollection 2019. – URL: https://www.dovepress.com/mechanisms-behind-prometastatic-changes-induced-by-neoadjuvant-chemoth-peer-reviewed-fulltext-article-BCTT

Grants

1. Russian Science Foundation No. 19-15-00151 “The role of monocyte programming in the development of pro- and anti-tumor phenotypes of tumor-associated macrophages and efficiency of chemotherapy in colorectal cancer”, 2019-2021.
2. Russian Foundation for Basic Research No. 17-29-06037 “Genomic regulation of the breast cancer progression during chemotherapy”, 2017-2019.
3. ERA NET. Russian Foundation for Basic Research No. 16-54-76015 “Alphavirus-based delivery of chitinase-like-protein gene for anti-tumour programing of macrophages (Alpha-Chit, 274)”, 2016-2018.
4. Russian Science Foundation No. 14-15-00350 “Molecular mechanism of action of regulatory proteins of type 2 macrophages on tumor microenvironment and tumor progression”, 2014-2018.

Publications

1. Buldakov M., Zavyalova M., Krakhmal N., Telegina N., Vtorushin S., Mitrofanova I., Riabov V., Yin S., Song B., Cherdyntseva N., Kzhyshkowska J. CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer // Immunobiology. 2015 Sep 8. pii: S0171-2985(15)30062-0. doi: 10.1016/j.imbio.2015.09.011[Epub ahead of print]. – URL: https://www.sciencedirect.com/science/article/pii/S0171298515300620?via%3Dihub
2. Mitrofanova I, Zavyalova M, Telegina N, Buldakov M, Riabov V, Cherdyntseva N, Kzhyshkowska J. Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy // Immunobiology. 2016 Aug 4. pii: S0171-2985(16)30342-4. - doi: 10.1016/j.imbio.2016.08.001. - https://www.sciencedirect.com/science/article/pii/S0171298516303424?via%3Dihub
3. Tashireva LA, Denisov EV, Gerashchenko TS, Pautova DN, Buldakov MA, Zavyalova MV, Kzhyshkowska J, Cherdyntseva NV, Perelmuter VM. Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis // Immunobiology. 2017 Apr;222(4):631-640.- doi: 10.1016/j.imbio.2016.11.012. – URL: https://www.sciencedirect.com/science/article/pii/S0171298516304478?via%3Dihub
4. Stakheyeva M, Riabov V, Mitrofanova I, Litviakov N, Choynzonov E, Cherdyntseva N, Kzhyshkowska J. Role of the immune component of tumor microenvironment in the efficiency of cancer treatment: perspectives for the personalized therapy. // Curr Pharm Des. 2017 Jul 14. - doi: 10.2174/1381612823666170714161703.
5. Mitrofanova I., Zavyalova M., Telegina N., Buldakov M., Riabov V., Cherdyntseva N., Kzhyshkowska J. Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy // Immunobiology. – 2017. – Том 222, вып.1. – 101-109. - doi: 10.1016/j.imbio.2016.08.001. – URL: https://www.sciencedirect.com/science/article/pii/S0171298516303424?via%3Dihub
6. Buldakov, M., Zavyalova, M., Krakhmal, N.,Telegina, N., Vtorushin, S., Mitrofanova, I., Riabov, V., Yin, S., Song, B., Cherdyntseva, N, Kzhyshkowska, J. CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer (Article) // Immunobiology. – 2017. - Volume 222, Issue 1, 1 January . - Pages 31-38. – URL: https://reader.elsevier.com/reader/sd/pii/S0171298515300620?token=56FE65371AA5D0A0A5EFF26038B7569AB0FD0659DF8C41BADB533C6C508FEF6A598C186617D27C44FF7C8DCC84FAE533
7. Kzhyshkowska J, Bizzarri M, Apte R, Cherdyntseva N. Editorial: Targeting of Cancer Cells and Tumor Microenvironment: Perspectives for Personalized Therapy // Curr Pharm Des. 2017;23(32):4703-4704. doi: 10.2174/138161282332171221165319.
8. Mitrofanova I, Zavyalova M, Riabov V, Cherdyntseva N, Kzhyshkowska J. The effect of neoadjuvant chemotherapy on the correlation of tumor-associated macrophages with CD31 and LYVE-1 // Immunobiology . - 2018;223(6-7):449-59. - doi: 10.1016/j.imbio.2017.10.050. – URL: https://www.sciencedirect.com/science/article/pii/S0171298517302000
9. Ekaterina Nikitina, Irina Larionova, Evgeniy Choinzonov, Julia Kzhyshkowska Monocytes and Macrophages as Viral Targets and Reservoirs // Int. J. Mol. Sci. - 2018, 19, 2821. - doi:10.3390/ijms19092821. – URL: https://www.mdpi.com/1422-0067/19/9/2821/htm
10. Liu T, Larionova I, Litviakov N, Riabov V, Zavyalova M, Tsyganov M, Buldakov M, Song B, Moganti K, Kazantseva P, Slonimskaya E, Kremmer E, Flatley A, Klüter H, Cherdyntseva N, Kzhyshkowska J Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy // Oncoimmunology. 2018 Mar 13;7(6):e1436922. - doi: 10.1080/2162402X.2018.1436922. eCollection 2018. – URL: https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2018.1436922?needAccess=true
11. Stakheyeva M, Eidenzon D, Slonimskaya E, Patysheva M, Bogdashin I, Kolegova E, Grigoriev E, Choinzonov E, Cherdyntseva N. Integral characteristic of the immune system state predicts breast cancer outcome // Exp Oncol. - 2019. – Т. 41, № 1. - P. 32-38. – doi: 10.32471/exp-oncology.2312-8852.vol-41-no-1.12593. – URL: http://exp-oncology.com.ua/wp/wp-content/uploads/2019/03/2490.pdf?upload=
12. Larionova I, Cherdyntseva N, Liu T, Patysheva M, Rakina M, Kzhyshkowska J. Interaction of tumor-associated macrophages and cancer chemotherapy // OncoImmunology. - 2019, vol. 8, №. 7, e1596004 (15 pages). - doi: 10.1080/2162402X.2019.1596004. – URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527283/pdf/koni-08-07-1596004.pdf

Grants

1. Russian Foundation for Basic Research No. 17-29-06002 “Molecular markers of progression/inhibition of bronchial lesions for prognosis of the premalignant process and the risk of squamous lung cancer”, 2017-2019.
2. No. SP-1549.2018.4 “Mutational landscape of the premalignant changes in bronchial epithelium: epigenetic regulation and expression characteristics”, 2018-2020.
3. Russian Foundation for Basic Research No. 18-29-09124 “Hypomethylation of human-specific L1Hs retrotransposon family in lung cancer: oncotransformation relevance and diagnostic value”, 2018-2020.

Publications

1. Pankova, O.V., Denisov, E.V., Ponomaryova, A.A., Gerashchenko, T.S., Tuzikov, S.A., Perelmuter, V.M. Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium (2016) Tumor Biology, 37 (3), pp. 3599-3607. doi: 10.1007/s13277-015-4196-2. – URL: https://link.springer.com/content/pdf/10.1007%2Fs13277-015-4196-2.pdf
2. Denisov Evgeny V., Schegoleva Anastasia A., Gervas Polina A., Ponomaryova Anastasia A., Tashireva Lubov A., Boyarko Valentina V., Bukreeva Ekaterina B., Pankova Olga V., Perelmuter Vladimir M. Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression // Lung Cancer. - Volume 135, September 2019, Pages 21-28. - https://doi.org/10.1016/j.lungcan.2019.07.001. – URL: https://www.lungcancerjournal.info/article/S0169-5002(19)30524-0/pdf
3. Denisov E.V., Schegoleva A.A., Gerashchenko T.S., Skryabin N.A., Sleptcov A.A., Yakushina V.D., Lyapunova L.S., Tuzikov S.A., Pankova O.V., Perelmuter V.M. Gene expression profiling revealed 2 types of bronchial basal cell hyperplasia and squamous metaplasia with different progression potentials. Applied Immunohistochemistry & Molecular Morphology 2019 doi: 10.1097/PAI.0000000000000762 URL: https://www.ncbi.nlm.nih.gov/pubmed/30896548

Grants

1. No. SP-1330.2018.4 “Role of tumor microenvironment in the formation of breast cancer invasive properties”, 2018-2020.
2. RFBR №16-34-00415 mol_а “Defining the role of innate lymphoid cells in the formation of invasive properties invasive carcinoma not specific type”, 2016-2017

Publications

1. Tashireva LA, Zavgorodskaya KO, Perelmuter VM. Role of innate lymphoid cells during cancer. Tsitologiia 2016;58(12):901-7. URL: https://www.ncbi.nlm.nih.gov/pubmed/30188105
2. Tashireva, L. A., Denisov, E. V., Gerashchenko, T. S., Pautova, D. N., Buldakov, M. A., Zavyalova, M. V., Perelmuter, V. M. Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis. Immunobiology 2017; 222(4), 631–640. URL: https://doi.org/10.1016/j.imbio.2016.11.012
3. Tashireva, L. A., Perelmuter, V. M., Manskikh, V. N., Denisov, E. V., Savelieva, O. E., Kaygorodova, E. V., & Zavyalova, M. V. Types of immune-inflammatory responses as a reflection of cell–cell interactions under conditions of tissue regeneration and tumor growth. Biochemistry (Moscow) 2017; 82(5), 542–555. URL: https://doi.org/10.1134/S0006297917050029
4. Perelmuter, V. M., Tashireva, L. A., Savelieva, O. E., Denisov, E. V., Kaigorodova, E. V., Zavyalova, M. V., & Cherdyntseva, N. V. Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment. Breast Cancer: Targets and Therapy 2019; 11, 209–219. URL: https://doi.org/10.2147/BCTT.S175161

Grants

1. RFBR № 14-04-01881 “New approach to creating a "molecular portrait" of the tumor: analysis of circulating microRNAs from blood in lung cancer”, 2014-2016
2. Federal Special-Purpose Program № 14.575.21.0064 “Development of molecular signature of auto-antibodies to DNA adducts for early diagnosis of lung cancer”, 2014-2016
3. The fundamental research program of the Presidium of the Russian Academy of Sciences “Fundamental research for the development of biomedical technologies”, 2014-2018

Publications

1. Rykova E.Y., Zaporozhchenko I.A., Vlassov V.V., Laktionov P.P., Cherdyntseva N.V., Ponomaryova A.A. Circulating DNA-based lung cancer diagnostics and follow-up: looking for epigenetic markers // Translational Cancer Research. 2018. Т. 7. № 3. С. S153-S170. – doi: 00.21037/tcr.2018. 02.08. - URL: http://tcr.amegroups.com/article/view/19642/15289
2. Nataliya Babyshkina, Marina Zavyalova, Natalia Tarabanovskaya, Tatyana Dronova, Nadejda Krakhmal, Elena Slonimskaya, Julia Kzhyshkowska, Evgeny Choynzonov, Nadejda Cherdyntseva Predictive value of vascular endothelial growth factor receptor type 2 in triple-negative breast cancer patients treated with neoadjuvant chemotherapy // //Molecular and cellular biochemistry. – 2018. -Том 444, Выпуск: 1-2 Стр.: 197-206. - doi: - https://doi.org/10.1007/s11010-017-3244-1. – URL: https://link.springer.com/content/pdf/10.1007%2Fs11010-017-3244-1.pdf
3. Babyshkina, N., Vtorushin, S., Zavyalova, M., Patalyak, S., Dronova, T., Litviakov, N., Slonimskaya, E., Kzhyshkowska, J., Cherdyntseva, N., Choynzonov, E. The distribution pattern of ERα expression, ESR1 genetic variation and expression of growth factor receptors: association with breast cancer prognosis in Russian patients treated with adjuvant tamoxifen // Clinical and Experimental Medicine. - 2017 Aug;17(3):383-393. doi: 10.1007/s10238-016-0428-z. – URL: https://link.springer.com/content/pdf/10.1007%2Fs10238-016-0428-z.pdf
4. Vlassov V.V., Rykova E.Y., Zaporozhchenko I.A., Morozkin E.S., Laktionov P.P., Ponomaryova A.A., Cherdyntseva N.V. Circulating microRNAs in lung cancer: Prospects for diagnosis, prognosis, and prediction of antitumor treatment efficacy. Mol Biol (Mosk). 2015;49(1):55-66. URL: https://link.springer.com/article/10.1134/S0026893315010161
5. Ponomaryova AA, Morozkin ES, Rykova EY, Zaporozhchenko IA, Skvortsova TE, Dobrodeev АY, Zavyalov AA, Tuzikov SA,Vlassov VV, Cherdyntseva NV, Laktionov PP, Choinzonov EL Dynamic changes in circulating miRNA levels in response to antitumor therapy of lung cancer. Exp Lung Res 2016;42(2):95-102. URL: https://www.ncbi.nlm.nih.gov/pubmed/26986825
6. Ponomaryova A.A., Cherdyntseva N.V., Bondar A.A., Dobrodeev A.Y., Zavyalov A.A., Tuzikov S.A., Vlassov V.V., Choinzonov E.L., Laktionov P.P., Rykova E.Y. Dynamics of LINE-1 retrotransposon methylation levels in circulating DNA from lung cancer patients undergoing antitumor therapy. Mol Biol (Mosk) 2017;51(4):622-628. URL: http://molecbio.ru/?view=article&id=4517
7. Ponomaryova A., Rykova E., Cherdyntseva N., Skvortsova T., Dobrodeev A, Zav’yalov A., Bryzgalov L., Tuzikov S., Vlassov V., Laktionov P. Potentialities of aberrantly methylated circulating DNA for diagnostics and post-treatment follow-up of lung cancer patients. Lung Cancer 2018;81(3):397-403. URL: https://www.ncbi.nlm.nih.gov/pubmed/23806794
8. Rykova E.Y., Ponomaryova A.A., Zaporozhchenko I.A., Vlassov V.V., Cherdyntseva N.V., Laktionov P.P. Circulating DNA-based lung cancer diagnostics and follow-up: looking for epigenetic markers. Translational Cancer Research 2018;7(Suppl. 2):S153-170. URL: http://tcr.amegroups.com/article/view/19642

Publications

1. Breast Scintigraphy with 199Tl in Diagnosis of Breast Cancer //Titskaya Anna, Chernov Vladimir, Slonimskaya Elena, Sinilkin Ivan, Zelchan Roman / Advanced Materials Research Vol. 1084 (2015) pp 361-364
2. Diagnostic Efficiency of Single-Photon Emission Computed Tomography with 99MTc-MIBI in Visualization of Malignant Tumors of the Larynx and Laryngopharynx/ Zelchan Roman, Chernov Vladimir, Titskaya Anna, Sinilkin Ivan, Chizhevskaya Svetlana, Choynzonov Yevgeniy Ts./ Advanced Materials Research Vol. 1084 (2015) pp 373-376
3. Possibility for Application of 99mTc-methoxyisobutylisonitrile in Assessing the Efficiency of Chemotherapy Cardiotoxicity Prevention /Vladimir Chernov, Tatiana Kravchuk, Roman Zelchan, Dmitriy Podoplekin, Victor Goldberg /Advanced Materials Research Vol. 1084 (2015) pp 426-429
4. Radionuclide Diagnosis of Breast Cancers / Titskaya Anna, Chernov Vladimir, Slonimskaya Elena, Sinilkin Ivan, Zelchan Roman /Advanced Materials Research Vol. 1084 (2015) pp 460-463
5. Single-photon Emission Computed Tomography and 99mTc-methoxyisobutyl-isonitrile in the Detection and Forecast of Cardiotoxicity of Chemotherapeutic Agents / Chernov Vladimir I., Kravchuk Tatiana V., Zelchan Roman V., Podoplekin Dmitrii M., Goldberg Viktor E. /Advanced Materials Research Vol. 1084 (2015) pp 471-475
6. Single-Photon Emission Computed Tomography with 199Tl in Diagnostics of Malignant Tumors of the Larynx and Laryngopharynx / Zelchan Roman, Chernov Vladimir, Titskaya Anna, Sinilkin Ivan, Chizhevskaya Svetlana, Choynzonov Yevgeniy Ts./ Advanced Materials Research Vol. 1084 (2015) pp 476-478
7. V I Chernov, A A Medvedeva, R V Zelchan, I G Sinilkin,, E S Stasyuk, L A Larionova, E M Slonimskaya, E L Choynzonov. Radiopharmaceuticals for SPECT Cancer Detection / IOP Conf. Series: Materials Science and Engineering 135 (2016) 012008 doi:10.1088/1757-899X/135/1/012008
8. I. Sinilkin, A. Medvedeva, V. Chernov, E. Slonimskaya, R. Zelchan, O. Bragina. Nuclear medicine in breast cancer diagnostics: Primary tumor and lymphatic metastasis. AIP Conference Proceedings 1882, 020070 (2017); https//doi.org/10.1063/1.5001649.
9. V. Chernov, R. Zeltchan, A. Medvedeva, I. Sinilkin,O. Bragina. Nuclear medicine in cancer diagnosis and therapy. AIP Conference Proceedings 1882, 020014 (2017); https//doi.org/10.1063/1.5001593.

Publications

1. Experimental Investigation of 99mТс-nanotech used for Lymph Nodes Visualization /Sinilkin Ivan, Chernov Vladimir, Titskaya Anna, Zelchan Roman, Daneikina Natalya/ Advanced Materials Research Vol. 1084 (2015) pp 373-376
2. Possibility of Nanocolloid Radiopharmaceutical Using for the Visualization of Sentinel Lymph Nodes in Patients with Gastric Cancer / Sinilkin Ivan, Chernov Vladimir, Afanas’ev Sergey, Titskaya Anna, Zelchan Roman /Advanced Materials Research Vol. 1084 (2015) pp 577-581
3. Possibility to Use the Radiopharmaceutical Based on the Gamma-Aluminum Oxide Labeled with 99mTc to Identify Sentinel Lymph Nodes in the Experiment /Chernov Vladimira, Titskaya Anna, Sinilkin Ivan, Zelchan Roman, Varlamova Natalya /Advanced Materials Research Vol. 1084 (2015) pp 443-446
4. Using Nanotech Radiopharmaceutical for the Visualization of Sentinel Lymph Nodes in Patients with Cervical Cancer / Sinilkin Ivan, Chernov Vladimir, Chernyshova Alena, Kolomiets Larisa, Titskaya Anna, Zelchan Roman /Advanced Materials Research Vol. 1084 (2015) pp 540-544
5. Using Nanotech Radiopharmaceutical for the Visualization of Sentinel Lymph Nodes in Patients with Larynx and Hypopharynx Cancer / Sinilkin Ivan, Chernov Vladimir, Choynzonov Evgeniy, Chizhevskaya Sletlana, Titskaya Anna, Zelchan Roman / Advanced Materials Research Vol. 1084 (2015) pp 545-548
6. A.A. Medvedeva, I.G. Sinilkin, R.V. Zelchan, V.I. Chernov, A.Yu. Lyapunov1, O.D. Bragina, N.V. Varlamova, V.S. Skuridin, A.P. Dergilev. The Study of 99mTc-Aluminum Oxide Using for Sentinel Lymph Nodes Detection in Experiment /IOP Conf. Series: Materials Science and Engineering 135 (2016) 012027 doi:10.1088/1757-899X/135/1/012027
7. A Doroshenko, V Chernov, A Medvedeva, R Zeltchan, E Slonimskaya, N Varlamova, V Skuridin, A Dergilev, I Sinilkin. The first experience of using of 99mTc-Al2O3 for detection of sentinel lymph nodes in breast cancer / IOP Conf. Series: Materials Science and Engineering 135 (2016) 012011 doi:10.1088/1757-899X/135/1/012011
8. I G Sinilkin, V I Chernov, A Yu Lyapunov, A A Medvedeva, R V Zelchan1, A L Chernyshova, L A Kolomiets. The use of 99mTc-Al2O3 for detection of sentinel lymph nodes in cervical cancer patients / IOP Conf. Series: Materials Science and Engineering 135 (2016) 012043 doi:10.1088/1757-899X/135/1/012043
9. I. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov, A. A. Medvedeva, R. V. Zelchan, A. L. Chernyshova, L. A. Kolomiets. The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients / Citation: AIP Conference Proceedings 1760, 020060 (2016); doi: 10.1063/1.4960279 View online: http//dx.doi.org/10.1063/1.4960279
10. A. L. Chernyshova, L. A. Kolomiets, I. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov. Optimization of the extent of surgical treatment in patients with stage I in cervical Cancer / Citation: AIP Conference Proceedings 1760, 020013 (2016); doi: 10.1063/1.4960232 View online: http//dx.doi.org/10.1063/1.4960232
11. I. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov, A. A. Medvedeva, R. V. Zelchan, A. L. Chernyshova, L. A. Kolomiets, and O. D. Bragina. Clinical significance of sentinel lymph node detection in patients with invasive cervical cancer / AIP Conference Proceedings 1882, 020069 (2017); https//doi.org/10.1063/1.5001648
12. I. Sinilkin, A. Medvedeva, V. Chernov, E. Slonimskaya, R. Zelchan, O. Bragina. Nuclear medicine in breast cancer diagnostics: Primary tumor and lymphatic metastasis. AIP Conference Proceedings 1882, 020070 (2017); https//doi.org/10.1063/1.5001649.
13. I. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov, A. A. Medvedeva, R. V. Zelchan, A. L. Chernyshova, L. A. Kolomiets, O. D. Bragina. Clinical significance of sentinel lymph node detection in patients with invasive cervical cancer. AIP Conference Proceedings 1882, 020069 (2017); https//doi.org/10.1063/1.5001648.

Grants

1. Federal target program "Development of the pharmaceutical and medical industry of the Russian Federation for the period up to 2020 and beyond" "Preclinical studies of a new lymphotropic radiopharmaceutical based on technetium-99m labeled gamma-alumina."
2. Federal target program "Development of the pharmaceutical and medical industry of the Russian Federation for the period up to 2020 and beyond" "Preclinical studies of a radiopharmaceutical based on a 99mTc labeled glucose derivative for the radionuclide diagnosis of cancer."
3. Federal target program "Development of the pharmaceutical and medical industry of the Russian Federation for the period up to 2020 and beyond" "Preclinical studies of a radiopharmaceutical based on technetium-99m labeled doxorubicin for scintigraphic imaging of malignant neoplasms and prognosis of the effectiveness of chemotherapy."
4. Federal target program "Development of the pharmaceutical and medical industry of the Russian Federation for the period up to 2020 and beyond" “Preclinical studies of a radiopharmaceutical based on 99mTc-labeled recombinant targeted molecules for the radionuclide diagnosis of cancer with Her-2 / neu overexpression.”
5. Federal target program "Development of the pharmaceutical and medical industry of the Russian Federation for the period up to 2020 and beyond" "Preclinical studies of a radiopharmaceutical based on 99mTc labeled octreotide for radionuclide diagnosis of neuroendocrine tumors."

Publications

1. Experimental Investigation of 99mТс-nanotech used for Lymph Nodes Visualization /Sinilkin Ivan, Chernov Vladimir, Titskaya Anna, Zelchan Roman, Daneikina Natalya/ Advanced Materials Research Vol. 1084 (2015) pp 373-376
2. Possibility of Nanocolloid Radiopharmaceutical Using for the Visualization of Sentinel Lymph Nodes in Patients with Gastric Cancer / Sinilkin Ivan, Chernov Vladimir, Afanas’ev Sergey, Titskaya Anna, Zelchan Roman /Advanced Materials Research Vol. 1084 (2015) pp 577-581
3. Possibility to Use the Radiopharmaceutical Based on the Gamma-Aluminum Oxide Labeled with 99mTc to Identify Sentinel Lymph Nodes in the Experiment /Chernov Vladimira, Titskaya Anna, Sinilkin Ivan, Zelchan Roman, Varlamova Natalya /Advanced Materials Research Vol. 1084 (2015) pp 443-446
4. Using Nanotech Radiopharmaceutical for the Visualization of Sentinel Lymph Nodes in Patients with Cervical Cancer / Sinilkin Ivan, Chernov Vladimir, Chernyshova Alena, Kolomiets Larisa, Titskaya Anna, Zelchan Roman /Advanced Materials Research Vol. 1084 (2015) pp 540-544
5. Using Nanotech Radiopharmaceutical for the Visualization of Sentinel Lymph Nodes in Patients with Larynx and Hypopharynx Cancer / Sinilkin Ivan, Chernov Vladimir, Choynzonov Evgeniy, Chizhevskaya Sletlana, Titskaya Anna, Zelchan Roman / Advanced Materials Research Vol. 1084 (2015) pp 545-548
6. A.A. Medvedeva, I.G. Sinilkin, R.V. Zelchan, V.I. Chernov, A.Yu. Lyapunov1, O.D. Bragina, N.V. Varlamova, V.S. Skuridin, A.P. Dergilev. The Study of 99mTc-Aluminum Oxide Using for Sentinel Lymph Nodes Detection in Experiment /IOP Conf. Series: Materials Science and Engineering 135 (2016) 012027 doi:10.1088/1757-899X/135/1/012027
7. A Doroshenko, V Chernov, A Medvedeva, R Zeltchan, E Slonimskaya, N Varlamova, V Skuridin, A Dergilev, I Sinilkin. The first experience of using of 99mTc-Al2O3 for detection of sentinel lymph nodes in breast cancer / IOP Conf. Series: Materials Science and Engineering 135 (2016) 012011 doi:10.1088/1757-899X/135/1/012011
8. I G Sinilkin, V I Chernov, A Yu Lyapunov, A A Medvedeva, R V Zelchan1, A L Chernyshova, L A Kolomiets. The use of 99mTc-Al2O3 for detection of sentinel lymph nodes in cervical cancer patients / IOP Conf. Series: Materials Science and Engineering 135 (2016) 012043 doi:10.1088/1757-899X/135/1/012043
9. R. Zeltchan1, A. Medvedeva, I. Sinilkin1, O. Bragina, V. Chernov, E. Stasyuk, A. Rogov, E. Il’ina, L. Larionova, V. Skuridin, A. Dergilev. Experimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosis / IOP Conf. Series: Materials Science and Engineering 135 (2016) 012054 doi:10.1088/1757-899X/135/1/012054
10. V. I. Chernov, I. G. Sinilkin, R. V. Zelchan, A. A. Medvedeva, A. Yu. Lyapunov, O. D. Bragina, N. V. Varlamova, and V. S. Skuridin. Experimental Study of 99mTc-Aluminum Oxide Use for Sentinel Lymph Nodes Detection / Citation: AIP Conference Proceedings 1760, 020012 (2016); doi: 10.1063/1.4960231 View online: http//dx.doi.org/10.1063/1.4960231
11. V. S. Skuridin, V. I. Chernov, V. L. Sadkin, E. S. Stasyuk, N. V. Varlamova, A. S. Rogov, E. A. Nesterov, E. A. Ilina, L. A. Larionova, and A. A. Medvedeva. Factors affecting eluation characteristics of sorption generators of technetium-99m / Citation: AIP Conference Proceedings 1760, 020062 (2016); doi: 10.1063/1.4960281 View online: http//dx.doi.org/10.1063/1.4960281
12. R. Zeltchan, A. Medvedeva, I. Sinilkin, V. Chernov, E. Stasyuk, A. Rogov, E. Il’ina, L. Larionova, V. Skuridin. Study of potential utility of new radiopharmaceuticals based on technetium-99m labeled derivative of glucose / Citation: AIP Conference Proceedings 1760, 020072 (2016); doi: 10.1063/1.4960291 View online: http//dx.doi.org/10.1063/1.4960291
13. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov, A. A. Medvedeva, R. V. Zelchan, A. L. Chernyshova, L. A. Kolomiets. The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients / Citation: AIP Conference Proceedings 1760, 020060 (2016); doi: 10.1063/1.4960279 View online: http//dx.doi.org/10.1063/1.4960279
14. L. Chernyshova, L. A. Kolomiets, I. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov. Optimization of the extent of surgical treatment in patients with stage I in cervical Cancer / Citation: AIP Conference Proceedings 1760, 020013 (2016); doi: 10.1063/1.4960232 View online: http//dx.doi.org/10.1063/1.4960232
15. M. Larkina, E. Podrezova, O. Bragina, E. Stasyuk, M. Yusubov, V. Chernov, R. Zelchan, V. Skuridin, M. Belousov, and S. Deyev. The foundations of the development of technologies of the synthesis of radiopharmaceuticals / AIP Conference Proceedings 1882, 020043 (2017); https//doi.org/10.1063/1.5001622
16. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov, A. A. Medvedeva, R. V. Zelchan, A. L. Chernyshova, L. A. Kolomiets, and O. D. Bragina. Clinical significance of sentinel lymph node detection in patients with invasive cervical cancer / AIP Conference Proceedings 1882, 020069 (2017); https//doi.org/10.1063/1.5001648
17. Medvedeva, V. Chernov, R. Zeltchan, I. Sinilkin, O. Bragina, S. Chijevskaya, E. Choynzonov, A. Goldberg. Nuclear medicine imaging of locally advanced laryngeal and hypopharyngeal cancer. AIP Conference Proceedings 1882, 020048 (2017); https//doi.org/10.1063/1.5001627.
18. R. Zeltchan, A. Medvedeva, I. Sinilkin, O. Bragina, V. Chernov, E. Stasyuk, A. Rogov, E. Il’ina, V. Skuridin. Development and study of 99mTc-1-Thio-D-glucose for visualization of malignant tumors. AIP Conference Proceedings 1882, 020083 (2017); https//doi.org/10.1063/1.5001662.
19. Sinilkin, A. Medvedeva, V. Chernov, E. Slonimskaya, R. Zelchan, O. Bragina. Nuclear medicine in breast cancer diagnostics: Primary tumor and lymphatic metastasis. AIP Conference Proceedings 1882, 020070 (2017); https//doi.org/10.1063/1.5001649.
20. O. Bragina, M. Larkina, E. Stasyuk, V. Chernov, R. Zelchan, A. Medvedeva, I. Sinilkin, M. Yusubov, V. Skuridin, S. Deyev, M. Buldakov. In vitro evaluation of a specific radiochemical compound based on 99mTc-labeled DARPinG3 for radionuclide imaging of tumors overexpressing Her-2/neu. AIP Conference Proceedings 1882, 020007 (2017); https//doi.org/10.1063/1.5001586.
21. G. Sinilkin, V. I. Chernov, A. Yu. Lyapunov, A. A. Medvedeva, R. V. Zelchan, A. L. Chernyshova, L. A. Kolomiets, O. D. Bragina. Clinical significance of sentinel lymph node detection in patients with invasive cervical cancer. AIP Conference Proceedings 1882, 020069 (2017); https//doi.org/10.1063/1.5001648.
22. M. Larkina, E. Podrezova, O. Bragina, E. Stasyuk, M. Yusubov, V. Chernov, R. Zelchan, V. Skuridin, M. Belousov, S. Deyev. The foundations of the development of technologies of the synthesis of radiopharmaceuticals. AIP Conference Proceedings 1882, 020043 (2017); https//doi.org/10.1063/1.5001622.
23. Vorobyeva, O. Bragina, M. Altai, B. Mitran, A. Orlova, A. Shulga, G. Proshkina, V. Chernov, V. Tolmachev, and S. Deyev Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9_29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors/ Contrast Media & Molecular Imaging Volume 2018, Article ID 6930425, 11 pages.
24. Deyev S., Vorobyeva A., Schulga A., Proshkina G., Güler R., Löfblom J., Mitran B., Garousi J., Altai M., Buijs, J., Chernov V., Orlova A., Tolmachev V. Comparative Evaluation of Two DARPin Variants: Effect of Affinity, Size, and Label on Tumor Targeting Properties(Article) // Molecular Pharmaceutics.-2019.-V.16.-№ 3 P. 995-1008
25. Vorobyeva A, Schulga A, Konovalova E, Güler R, Löfblom J, Sandström M, Garousi J, Chernov V, Bragina O, Orlova A, Tolmachev V, Deyev S Optimal composition and position of histidine-containing tags improves biodistribution of 99mTc-labeled DARPin G3 // Scientific Reports volume 9, Article number: 9405 (2019) doi.org/10.1038/s41598-019-45795-8.