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Major fundamental research interests are:

To study cancer incidence, cancer-based morbidity and mortality in different ethnic populations on the territory of Siberia and the Russian Far East.

To reveal endogenous and exogenous etiological factors and their complexes to improve organization of cancer care for the population of the region.

To discover genetic and other molecular changes in tumor and tumor microenvironment to determine their role in clinical behavior and establish new molecular diagnostics and novel molecular therapeutic targets in cancer.

To study molecular mechanisms of breast cancer metastasis based on Lyden's metastatic niche concept and Paget "seed and soil" hypothesis as a platform for metastatic disease prediction and prevention.

To develop molecular diagnostic assays for routine clinical use in oncology practice.

To characterize mechanisms of resistance to chemotherapy by integrating molecular profiling and functional genomics.

To promote rapid translation of basic discoveries of cancer mechanisms into the development of potential prognostic markers and therapeutic strategies.

To develop the most effective, safe, and cost-effective approaches for predictive, preventive and personalized oncology.

Results obtained from fundamental researches are translated into clinical applications.