Personalities

Renata R. Savchenko

Junior Researcher, Laboratory of Genomics of Orphan Diseases; PhD student, Laboratory of Cytogenetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center.

Contact details

mail: renata.savchenko@medgenetics.ru

tel.: 8 (3822) 51-31-46

fax: 8 (3822) 51-37-44

Biographical note

Renata R. Savchenko obtained a Master’s degree in biology from National Research Tomsk State University in 2017. In the same year, she was accepted to the postgraduate programme with educational program specialization "Genetics". The subject of the dissertation is "The role of the ADAMTS1 and THBS1 genes in the radiation-induced human somatic cellular response to DNA damage".

Research interests

The main scientific work of Renata R. Savchenko is dedicated to the study of the cellular response to DNA damage induced by ionizing radiation in human somatic cells and in the model systems obtained using genome editing technology.

Achievements, awards, grants

Renata R. Savchenko has participated in 4 scientific studies:

• The effect of the ADAMTS1 and THBS1 genes expression on the radiation-induced cellular response. (Russian Foundation for Basic Research, 19-34-90143).
• Epigenetic regulation of DNA damage cell response (Grant of the President of Russian Federation, МК-5944.2018.4).
• Identification of X-linked regions of the genome associated with an abnormality of the inactivation of the X chromosome and fetal death in humans (Russian Foundation for Basic Research, 18-015-00437 А).
• The role of meiotic silencing of structural genomic variation in the occurrence of paramutation and incomplete penetrance of human chromosomal pathology (Russian Science Foundation, 16-15-10229).

Important publications:

1.      Savchenko R.R., Vasilyev S.A., Fishman V.S., Sukhikh E.S., Sukhikh L.G., Murashkina A.A., Lebedev I.N. Effect of THBS1 Gene Knockout on the Radiation-Induced Cellular Response in a Model System in vitro // Russian Journal of Genetics. – 2020. –  V. 56. –  № 5. – PP. 618-626.

2.      Savchenko R.R., Vasilyev S.A., Fishman V.S., Murashkina A.A., Dorofeeva A.V., Lebedev I.N. Knockout of ADAMTS1 gene by CRISPR/Cas9 affect the micronucleus frequency but not the DNA repair signaling in HeLa cell line // 23rd International Colloquium on Animal Cytogenetics and Genomics (23rd ICACG), June 9-12, 2018, Saint-Petersburg, Abstracts. Comparative Cytogenetics, 2018. – V.12. – №3. – P. 348-349.

3.      Savchenko RR, Vasilyev SA, Skryabin NA, Fishman VS, Serov OL, Lebedev IN. The role of the ADAMTS1, THBS1, WHSC1, RBFOX2 genes in the radiation-induced human somatic cellular response to DNA damage // Chromosomes And Mitosis: International Miniconference. Novosibirsk, Russia, December 8, 2017 : Abstracts. – Novosibirsk, 2017. – P.13

4.      Savchenko R.R., Vasilyev S.A., Fishman V.S. H3 gistone methylation level in the ADAMTS1, THBS1 and RBFOX2 knockout cell lines // Prospects of Fundamental Sciences Development: Proceedings Of The XV International Conference of students, graduate students and young scientists, April 24-27, 2018. [Electronic resource] / ed. by I.A. Kurzina, G.A. Voronova. – Tomsk: Publishing house of National Research Tomsk Polytechnic University,– 2018. – V. 4. – PP.137-139.

5.      Savchenko R.R., Vasilev S.A., Fishman V.S., Murashkina A.A., Dorofeeva A.V., Lebedev I.N. Effect of the products of the RBFOX2 and THBS1 genes on histone methylation in knockout cell lines // Current Issues Of Basic And Clinical Medicine: Proceedings Of The Conference Of Young Scientists, May 24–25, 2018 [Electronic resource] / ed. by E. L. Choinzonov, E. V. Galazhinsky, S. V. Popov, N. A. Bohan, V. A. Stepanov, V. V. Zhdanov; Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk State University. - Tomsk: Publishing house of Tomsk University, 2018. – PP. 124-126.

6.      Savchenko R.R., Vasilyev S.A., Fishman V.S., Murashkina A.A., Dorofeeva A.V., Sukhikh E.S., Lebedev I.N. Effects of ADAMTS1 and THBS1 genes knockout on the radiation-induced DNA damage cellular response // Chromosome 2018: International Conference. August 20–24, 2018, Novosibirsk, Russia: Abstracts / Institute of Molecular and Cellular Biology SB RAS; Novosibirsk State University. – Novosibirsk, 2018. – PP. 171-172.

7. Kashevarova A.A., Skryabin N.A., Nikitina T.V., Lopatkina M.E., Sazhenova E.A., Zhigalina D.I., Savchenko R.R., Lebedev I.N. Ontogenetic Pleiotropy of Genes Involved in CNVs in Human Spontaneous Abortions // Russian Journal of Genetics. – 2019. – V. 55. – № 10. – PP. 1214-1226.

8. Savchenko R.R., Kashevarova A.A., Skryabin N.A., Zhigalina D.I., Lopatkina M.E., Nikitina T.V., Vasilyev S.A., Lebedev I.N. Analysis of CNVs in anembrionic pregnancy and missed abortions // Medicine Genetics. – 2018. – V. 17. – № 3. – С. 49-54.

9. Anna A. Kashevarova, Elena O. Belyaeva, Aleksandr M. Nikonov, Olga V. Plotnikova, Nikolay A. Skryabin, Tatyana V. Nikitina, Stanislav A. Vasilyev, Yulia S. Yakovleva, Nadezda P. Babushkina, Ekaterina N. Tolmacheva, Mariya E. Lopatkina, Renata R. Savchenko, Lyudmila P. Nazarenko and Igor N. Lebedev Compound phenotype in a girl with r(22), concomitant microdeletion 22q13.32-q13.33 and mosaic monosomy 22. A.A. Kashevarova [et al.] // Molecular Cytogenetics / – 2018. – V. 11. – №26. – P.9