Personalities

Tatiana Yu. Poliakova (Khrichkova)

Tatiana Yu. Poliakova, MD, DSc, Senior Researcher, Laboratory of Pathophysiology and Experimental Therapy of Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center.

Contact details

e-mail: tasha93@mail.ru
tel.: +7 (3822) 41-83-72
fax: +7 (3822) 41-83-79

Brief Biography

In 1999, she graduated from the Medico-Biological Faculty of the Siberian State Medical University, Tomsk (SSMU). From 1999 to 2002, she had a postgraduate study in Research Institute of Pharmacology (Tomsk) and got a PhD. From 2002 to 2009, she held a position of a researcher of Laboratory of Pathophysiology and Experimental Therapy, Research Institute of Pharmacology (Tomsk). In 2009 she got DSc degree. From 2009 till present, she is a Senior Researcher of Laboratory of Pathophysiology and Experimental Therapy, Research Institute of Pharmacology.

Scientific interests

Tatiana Yu. Poliakova is a specialist in the field of pharmacology, oncology, pathophysiology and regenerative medicine. One of her scientific interests is the study of myelotoxicity of modern chemotherapy regimens in patients with different types of cancer and dissection of the mechanisms underlying their hematological effects. Her current research focuses on the study of the role of progenitor cells of various classes in the development and resolution of pathological processes as well as the development of drugs for regenerative medicine. T. Yu. Poliakova is the author of 120 scientific works, «The methodical recommendations on the study of specific activity drugs for regenerative medicine" and "The methodical recommendations on the study of haemostimulation activity of pharmacological substances". She has 14 patents for inventions. Under the leadership of T. Polyakova, 1 dissertation for PhD degree was defended.

Achievements, awards, grants

Winner of Tomsk Region Competition in Education and Science (2003), Tomsk Region Award in the field of education, science, health and culture (2010). Participation in the Federal target program "PHARMA 2020" and Federal target program "Scientific and scientific-pedagogical staff of innovative Russia" at 2009-2013", Russian Foundation for Basic Research grants (2009, 2018). She is a member of Russian Scientific Cociety of Pharmacology.

Main Publications

1. Patent RU № 2589288 “Method for stimulating production of erythropoietin in a cell culture in vitro” (published 10.12.2014, Newsletter, no. 34). Authors: Dygai A., Zdanov V.V., Zuz′kov G.N., Miroshnichenko L.A., Udut E.V., Khrichkova T.Yu., Simanina E.V. e.a. (http://www.fips.ru/Archive4/PAT/2016FULL/2016.07.10/DOC/RUNWC1/000/000/002/589/288/document.pdf).


2. Dygai A.M., Zhdanov V.V., Zyuzkov G.N., Udut E.V., Miroshnichenko L.A., Simanina E.V., Chaikovskii A.V., Stavrova L.A., Danilets M.G., Agafonov V.I., Khrichkova T.Y. INVOLVEMENT OF NF-κB-DEPENDENT SIGNALING AND P38 MAPK SIGNALING PATHWAY IN THE REGULATION OF HEMOPOIESIS DURING RESTRAIN STRESS Bulletin of Experimental Biology and Medicine. (Published: Springer Science+Business Media, Inc., New York, USA) 2014. Vol. 157. № 5. P. 548-551. (DOI: 10.1007/s10517-014-2611-0) (http://link.springer.com/article/10.1007/s10517-014-2611-0).


3. Zyuz’kov G. N., Zhdanov V. V., Udut E. V., L.A. Miroshnichenko, E.V. Simanina, T.Yu. Polyakova, е.а. Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA), 2016, Volume 161, Issue 2, pp 224–227.( http://link.springer.com/article/10.1007/s10517-016-3381-7; импакт-фактор по 2015 JCR Science Edition 0,448).


4. Squamous cell head and neck carcinoma: Molecular bases of pathogenesis. Choinzonov E.L., Kondakova I.V., Spirina L.V., Lebedev I.N., Goldberg V.E., Chizhevskaya S.Yu., Shishkin D.A., Urazova L.N., Kakurina G.V., Bychkov V.A., Khrichkova T.Yu., Melnikov A.A. – Moscow.: Science, 2016. – 224p (http://elibrary.ru/item.asp?id=26354899).


5. Mechanisms of activation of hematopoietic recovery due to filgastrim in breast cancer patients receiving chemotherapy with doxorubicin/docetaxel. Khrichkova T.Yu., Goldberg V.E., Popova N.O., Simolina E.I., Belevich Yu.V., Zhdanov V.V., Miroshnichenko L.A., Udut E.V.1, Simanina E.V. Siberian journal of oncology. 2015. № 6. С. 46-51. (http://elibrary.ru/item.asp?id=25055723)


6. Role of cAMP- and IKK-2-Dependent Signaling Pathways in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine. Zyuz’kov G.N., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Chaikovskii A.V., Simanina E.V., Polyakova T.Y., Minakova M.Y., Udut V.V., Stavrova L.A., Burmina Y.V., Suslov N.I., Dygai A.M., Tolstikova T.G., Shul’ts E.E. Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA). 2015. Т. 159. № 5. С. 642-645. (DOI: 10.1007/s10517-015-3036-0) (http://link.springer.com/article/10.1007/s10517-015-3036-0 ;импакт-фактор по 2015 JCR Science Edition 0,448).


7. Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor. Zyuz'kov G.N., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Khrichkova T.Y., Danilets M.G., Simanina E.V., Chaikovskii A.V., Agafonov V.I., Sherstoboev E.Y., Minakova M.Y., Burmina Y.V., Udut V.V., Dygai A.M. Bulletin of Experimental Biology and Medicine.(Published: Springer Science+Business Media, Inc., New York, USA). 2015. Т. 159. № 4. С. 479-481. (DOI: 10.1007/s10517-015-2997-3)(http://link.springer.com/article/10.1007/s10517-015-2997-3)


8. Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development. Zyuz’kov G.N., Losev E.A., Chaikovskii A.V., Suslov N.I., Zhdanov V.V., Udut E.V., Miroshnichenko L.A., Simanina E.V., Polyakova T.Y., Povet’eva T.N., Nesterova Y.V., Stavrova L.A., Udut V.V., Minakova M.Y., Dygai A.M. Bulletin of Experimental Biology and Medicine. (Published: Springer Science+Business Media, Inc., New York, USA). 2016. Т. 161. № 1. С. 45-49. (DOI: 10.1007/s10517-016-3341-2) (http://link.springer.com/article/10.1007/s10517-016-3341-2)


9. L. A. Miroshnichenko, V. V. Zhdanov, E. V. Udut, T. Yu. Polyakova, G. N. Zyuz’kov, E. V. Simanina, E. Yu. Sherstoboev, L. A. Stavrova, V. I. Agafonov, M. Yu. Minakova, A. V. Chaikovskii, A. M. Dygai Role of NF-κB, PI3K, MAPK/ERK 1/2, and p38 in Erythropoietin Production by Bone Marrow Nuclears under Conditions of Immobilization Stress // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA) 2017, Volume 163, Issue 3, pp 352–355 (https://link.springer.com/article/10.1007/s10517-017-3802-2; импакт-фактор по 2017 JCR Science Edition 0,546).


10. G. N. Zyuz’kov, E. V. Udut, L. A. Miroshnichenko е.а. Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA), 2017, Volume 163, Issue 4, pp 443–446. ( https://link.springer.com/content/pdf/10.1007%2Fs10517-017-3824-9.pdf; IF 2017 JCR Science Edition 0.546).


11. G. N. Zyuz’kov, N. I. Suslov, T. N. Povet’eva, e.a. Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development // Bulletin of Experimental Biology and Medicine (Published: Springer Science+Business Media, Inc., New York, USA), 2017, Volume 163, Issue 1, pp 18–21. ( https://link.springer.com/content/pdf/10.1007%2Fs10517-017-3727-9.pdf; IF 2017 JCR Science Edition 0.546).


12. V.E. Goldberg, T.Yu. Poliakova, N.O. Popova, V.V. Vysotskaya, E.I. Simolina, U.V. Belevich, E.A. Dudnikova, N.M. Goncharova, T.P. Tuzikova, A.V. Goldberg, L.A. Miroshnichenko, E.V. Udut, E.V. Simanina, G.N. Zyuz'kov, V.V. Zhdanov, A.M. Dygai Mechanisms of activation of granulocytopoiesis recovery due to filgrastim in breast cancer patients receiving chemotherapy Bulletin of Experimental Biology and Medicine. 2018. Vol. 166. № 7. P. 71-76. (https://elibrary.ru/item.asp?id=35184677)


13. Polyakova T.Y., Zhdanov V.V., Miroshnichenko L.A., Udut E.V., Simanina E.V., Dygai A.M., Zyuz'kov G.N., Goldberg V.E., Popova N.O., Vysotskaya V.V., Simolina E.I., Belevich Y.V., Tuzikova T.P., Goldberg A.V. Assessment of erythroid and granulocytic hematopoietic lineages in patients with non-small-cell lung carcinoma


14. Bulletin of Experimental Biology and Medicine. (Published: Springer Science+Business Media, Inc., New York, USA). 2017. Т. 163. № 4. С. 469-474.(DOI: 10.1007/s10517-017-3830-y) (https://link.springer.com/article/10.1007/s10517-017-3830-y; IF 2016 JCR Science Edition 0.546).