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Personalities

Tatiana S. Gerashchenko

Tatiana S. Gerashchenko

PhD, Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk NRMC

Contact details

email: t_gerashenko@list.ru

phone: +7(3822) 282676, add 3345; 

 

Brief CV

Work experience:

September 2019-Present: Researcher, Laboratory of Cancer Progression Biology, Cancer Research Institute, Tomsk National Research Medical Center

2014-Present: Junior Researcher, Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University

2016-2019: Junior Researcher, Laboratory of Molecular Oncology and Immunology, Cancer Research Institute, Tomsk National Research Medical Center

2013-2016: PhD student, Laboratory of Molecular Oncology and Immunology, Tomsk Cancer Research Institute

International experience:

05.05.2014 – 02.06.2014: Traineeship in Institute for Transfusion Medicine and Immunology, University of Heidelberg, Heidelberg, Germany

18.10.2014 – 29.10.2014 - Traineeship in ECCPS Microarray Unit, University of Giessen, Giessen, Germany 

Education:

2012-2013: Internship, Siberian State Medical University.

2006-2012: MD student, Department of Biochemistry and Molecular Biology, Siberian State Medical University. Training and MD research work at Tomsk Cancer Research Institute

Research Interests 

Intratumoral morphological heterogeneity of breast cancer: nature and clinical significance. Molecular mechanisms of breast cancer invasion and metastasis.

Premalignant process in bronchial epithelium: genotypic factors, involved in metastasis and recurrence of patients with NSCLC.

Projects:

Gerashchenko T.S. was involved in more than ten projects, supported by Russian Science Foundation (RSF), Russian Foundation for Basic Research (RFBR), Russian President Grants and others.

Current major projects:

- «Genetic alterations involved in tumor cell invasion and their role in breast cancer development» (RFBR, 2018-2021)

- «New strategy for the prediction and prevention of distant metastasis based on the detection of circulating metastasis-initiating and niche-forming cells and their specific targets» (RSF, 2019-2022)

- «Ethno-specific mutations, predisposing to breast cancer development among the indigenous population of Siberia and the Far East» (RFBR, 2018-2021)

Awards 

Tomsk region award in field of education, science and medicine holder (2018)

Russian Government scholarship holder (2011/2012; 2015/2016)

ESO (2015) Travel Grant holder

State Duma of Tomsk region award holder (2015)

Administration of Tomsk region’ scholarship holder (2014/2015)

Scholarship of «Pfizer» for overseas training (2014)

EACR Meeting Bursary Award (2013)

Fellowship of Russian Winter School «Modern Biology&Future Biotech» (2013)

Memberships

European Association for Cancer Research (EACR, 2013 - present)

Federation of European Biochemical Societies (FEBS, 2013 – present)

Publications

1.      L.A. Tashireva, M.V. Zavyalova, O.E. Savelieva, T.S. Gerashchenko, E.V. Kaigorodova, E.V. Denisov, V.M. Perelmuter. Single Tumor Cells With Epithelial-Like Morphology Are Associated With Breast Cancer Metastasis // Front. Oncol. – 2020. – Vol. 10, P. 1-12 https://www.frontiersin.org/articles/10.3389/fonc.2020.00050/full

2.      T.S. Gerashchenko, N. M. Novikov, N. V. Krakhmal, S.Y. Zolotaryova, M.V. Zavyalova, N.V. Cherdyntseva, E. V. Denisov and V. M. Perelmuter. Markers of Cancer Cell Invasion: Are They Good Enough? // Journal of Clinical Medicine. – 2019. – Vol. 8. – P. 2-18 https://www.ncbi.nlm.nih.gov/pubmed/31344926

3.      Denisov, E.V., Schegoleva, A.A., Gerashchenko, T.S., Skryabin, N.A., Sleptcov, A.A., Yakushina, V.D., Lyapunova, L.S., Tuzikov, S.A., Pankova, O.V., Perelmuter, V.M. Gene expression profiling revealed two types of bronchial basal cell hyperplasia and squamous metaplasia with different progression potentials. - Applied Immunohistochemistry & Molecular Morphology. – 2019. https://www.ncbi.nlm.nih.gov/pubmed/30896548

4.      Gerashchenko TS, Denisov EV, Novikov NM, Tashireva LA, Kaigorodova EV, Savelieva OE, Zavyalova MV, Cherdyntseva NV, Perelmuter VM. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles.// Exp Oncol. – 2018. - Vol.40, № 3. – P. 228-234. http://exp-oncology.com.ua/article/11551

5.      L.A. Tashireva, E.V. Denisov, T.S. Gerashchenko, D.N. Pautova, M.A. Buldakov, M.V. Zavyalova, J. Kzhyshkowska, N.V. Cherdyntseva, V.M. Perelmuter. Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis // Immunobiology. 2017 Apr;222(4):631-640. https://www.sciencedirect.com/science/article/pii/S0171298516304478?via%3Dihub

6.      E.V. Denisov, N. A. Skryabin, T. S. Gerashchenko, L. A. Tashireva, J. Wilhelm, M.A. Buldakov, A.A. Sleptcov, I.N. Lebedev, S.V. Vtorushin, M.V. Zavyalova, N.V. Cherdyntseva, V.M Perelmuter. Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+ CD24-stemness. – Oncotarget, 2017. – P. 1-17. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=18022&path[]=59000

7.      TS Gerashchenko, MV Zavyalova, EV Denisov, NV Krakhmal, DN Pautova, NV Litviakov, SV Vtorushin, NV Cherdyntseva, VM Perelmuter. Intratumoral Morphological Heterogeneity of Breast Cancer As an Indicator of the Metastatic Potential and Tumor Chemosensitivity // Acta Naturae. – 2017. – Vol.9 (1). – P. 56-67 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406661/

8.      Denisov E. V., Gerashchenko T. S., Zavyalova M. V., Manskikh V. N., Choinzonov E. L., Cherdyntseva N. V., and V. M. Perelmuter. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma. - Springer International Publishing Switzerland, 2016 B.I. Carr (ed.), Hepatocellular Carcinoma, Current Clinical Oncology. – P.211 – 228. https://link.springer.com/chapter/10.1007%2F978-3-319-34214-6_14

9.      L. A. Tashireva, E. V. Denisov, O. E. Savelieva, T. S. Gerashchenko, M. V. Zavyalova, V. M. Perelmuter. Heterogeneity of premetastatic niche gene expression in breast cancer cells // Biopolymers and Cell. 2015. Vol. 31. N 6. – P. 429–435 doi: http://dx.doi.org/10.7124/bc.000900

10. Olga V. Pankova, Evgeny V. Denisov, Anastasia A. Ponomaryova, Tatiana S. Gerashchenko, Sergey A. Tuzikov, Vladimir M. Perelmuter. Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium // Tumor Biology, 2016. –Vol. 37(3). - P.3599-3607. https://link.springer.com/article/10.1007/s13277-015-4196-2

11. Denisov E.V., Skryabin N.A., Vasilyev S.A., Gerashchenko T.S., Lebedev I.N., Zavyalova M.V., Cherdyntseva N.V., Perelmuter V.M. Relationship between morphological and cytogenetic heterogeneity in invasive micropapillary carcinoma of the breast: a report of one case // J Clin. Pathol., 2015. - Vol. 68(9). – P.758-762. http://jcp.bmj.com/content/68/9/758.long

12. E. V. Denisov, T. S. Gerashchenko, M. V. Zavyalova, N. V. Litviakov, M. M. Tsyganov, E. V. Kaigorodova, E. M. Slonimskaya, J. Kzhyshkowska, N. V. Cherdyntseva, V. M. Perelmuter. Invasive and drug resistant expression profile of different morphological structures of breast tumors // Neoplasma. – 2015 62(3), P.405-411. https://www.ncbi.nlm.nih.gov/pubmed/25672673

13. E.V. Denisov, N.V. Litviakov, M.V. Zavyalova, V.M. Perelmuter, S.V. Vtorushin, M.M. Tsyganov, T.S. Gerashchenko, E. Yu. Garbukov, E.M. Slonimskaya, N.V. Chedryntseva. Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistant gene expression // Scientific reports. – 2014. - N 4, 4709, P. 1-7. https://www.nature.com/articles/srep04709

14. Gerashchenko T.S., Denisov E.V., Litviakov N.V., Zavyalova M.V., Vtorushin S.V., Tsyganov M.M., Perelmuter V.M., Chedryntseva N.V. Intratumoral heterogeneity:nature and biological significant // Biochemistry (Moscow) / - 2013. – Vol. 78, P. 1201-1215. https://link.springer.com/article/10.1134%2FS0006297913110011

15. M.V. Zavyalova, E.V. Denisov, L.A. Tashireva, T.S. Gerashchenko, N.V. Litviakov, N.A. Skryabin, S.V. Vtoryshin, N.S. Telegina, E.M. Slonimskaya, N.V. Cherdyntseva, V.M. Perelmuter. Phenotypic Drift as a Cause for Intratumoral Morphological Heterogeneity of Invasive Ductal Breast Carcinoma Not Otherwise Specified // Bioresearch Open Access. - 2013. - Vol. 2, N. 2. – P. 148-154 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620470/